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TESTIS CANCER - Interactive survival scatter ploti
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average FPKM
734.2
Number of samples
134
Samples
Sample
Description
FPKM
TCGA-2G-AAHL-01A
26 years, male, white, stage:i, alive, 7081 days
1944.6
TCGA-VF-A8AE-01A
39 years, male, white, stage:ia, alive, 727 days
1803.6
TCGA-4K-AA1I-01A
26 years, male, white, stage:ia, alive, 3 days
1487.5
TCGA-ZM-AA0N-01A
44 years, male, white, stage:ib, alive, 634 days
1368.7
TCGA-ZM-AA0E-01A
39 years, male, white, stage:ia, alive, 811 days
1355.0
TCGA-ZM-AA06-01A
45 years, male, white, stage:ib, alive, 1498 days
1333.9
TCGA-2G-AAEX-01A
38 years, male, white, stage:is, alive, 1259 days
1317.7
TCGA-XE-AAO4-01A
40 years, male, white, stage:ia, alive, 367 days
1237.5
TCGA-VF-A8A9-01A
31 years, male, white, stage:ia, alive, 1119 days
1225.8
TCGA-YU-A90W-01A
45 years, male, white, stage:ia, alive, 1113 days
1211.7
TCGA-2G-AAH8-01A
45 years, male, white, stage:iiic, alive, 2248 days
1199.2
TCGA-2G-AAFM-01A
31 years, male, white, stage:iia, alive, 503 days
1197.3
TCGA-XE-AAO6-01A
47 years, male, white, stage:ia, alive, 240 days
1186.2
TCGA-SB-A6J6-01A
22 years, male, white, stage:ia, alive, 413 days
1185.1
TCGA-2G-AAHP-01A
31 years, male, white, stage:is, alive, 5667 days
1169.5
TCGA-ZM-AA0D-01A
34 years, male, white, stage:ia, alive, 848 days
1142.8
TCGA-XE-AANR-01A
24 years, male, white, stage:i, alive, 14 days
1134.4
TCGA-VF-A8AA-01A
51 years, male, white, stage:i, alive, 1146 days
1132.1
TCGA-XE-AAOD-01A
39 years, male, white, stage:ib, alive, 2058 days
1117.4
TCGA-2G-AAF6-01A
28 years, male, white, stage:is, alive, 3491 days
1097.5
TCGA-2G-AAKD-01A
18 years, male, white, stage:iii, alive, 6340 days
1074.3
TCGA-4K-AA1G-01A
34 years, male, white, stage:is, alive, 436 days
1025.5
TCGA-ZM-AA0B-01A
32 years, male, white, stage:ia, alive, 838 days
1008.8
TCGA-2G-AAHT-01A
32 years, male, white, stage:is, alive, 542 days
989.5
TCGA-VF-A8AC-01A
29 years, male, white, stage:ia, alive, 1083 days
982.0
TCGA-2G-AAFH-01A
38 years, male, white, stage:iib, alive, 1375 days
981.1
TCGA-SB-A76C-01A
38 years, male, white, alive, 42 days
976.4
TCGA-2G-AAL7-01A
32 years, male, white, stage:is, alive, 3991 days
969.8
TCGA-2G-AAHG-01A
25 years, male, white, stage:i, alive, 1819 days
965.2
TCGA-2G-AAFO-01A
33 years, male, white, stage:iia, alive, 685 days
945.4
TCGA-2G-AAHC-01A
33 years, male, white, stage:is, alive, 5539 days
945.0
TCGA-WZ-A7V5-01A
27 years, male, white, stage:i, alive, 1061 days
926.5
TCGA-2G-AAFE-01A
37 years, male, white, stage:iia, alive, 4702 days
918.6
TCGA-2G-AAHN-01A
32 years, male, white, stage:i, alive, 6445 days
918.2
TCGA-ZM-AA0H-01A
50 years, male, white, stage:is, alive, 1736 days
912.2
TCGA-XE-A9SE-01A
35 years, male, white, stage:ia, alive, 708 days
907.5
TCGA-SO-A8JP-01A
29 years, male, white, stage:i, alive, 540 days
903.7
TCGA-S6-A8JX-01A
27 years, male, white, stage:ib, alive, 552 days
902.7
TCGA-XE-AANJ-01A
39 years, male, white, stage:is, alive, 2007 days
886.6
TCGA-YU-A90Q-01A
21 years, male, stage:ib, alive, 1964 days
883.6
TCGA-WZ-A8D5-01A
38 years, male, white, alive, 774 days
880.5
TCGA-2G-AAGW-01A
38 years, male, white, stage:is, alive, 4899 days
862.9
TCGA-W4-A7U2-01A
26 years, male, white, alive, 1263 days
860.9
TCGA-2G-AAFN-01A
26 years, male, white, stage:iiib, alive, 773 days
855.3
TCGA-XY-A89B-01A
35 years, male, white, stage:ia, alive, 471 days
853.2
TCGA-2G-AAGZ-01A
27 years, male, white, stage:iiia, alive, 5233 days
819.0
TCGA-XE-AAOF-01A
50 years, male, asian, stage:ia, alive, 1268 days
814.2
TCGA-XE-AANV-01A
52 years, male, stage:ib, alive, 1701 days
808.2
TCGA-SN-A84X-01A
21 years, male, white, stage:is, alive, 312 days
803.1
TCGA-2G-AAG3-01A
53 years, male, white, stage:is, alive, 1593 days
801.6
TCGA-2G-AAEW-01A
31 years, male, white, stage:is, dead, 618 days
788.3
TCGA-S6-A8JY-01A
27 years, male, white, stage:is, alive, 278 days
782.1
TCGA-YU-A90S-01A
26 years, male, white, stage:ia, alive, 971 days
779.4
TCGA-SN-A84Y-01A
18 years, male, white, stage:is, alive, 524 days
777.7
TCGA-XE-A8H4-01A
23 years, male, white, stage:ia, alive, 559 days
766.3
TCGA-2G-AAF4-01A
30 years, male, white, stage:i, alive, 2315 days
735.8
TCGA-2G-AAGO-01A
41 years, male, white, stage:is, alive, 4026 days
725.3
TCGA-4K-AA1H-01A
26 years, male, white, stage:ia, alive, 518 days
719.7
TCGA-XE-AAO3-01A
33 years, male, asian, stage:i, alive, 2857 days
717.7
TCGA-VF-A8A8-01A
18 years, male, white, stage:ia, alive, 1131 days
715.6
TCGA-2G-AAF8-01A
33 years, male, white, stage:ia, alive, 3911 days
712.6
TCGA-4K-AAAL-01A
31 years, male, white, stage:is, alive, 483 days
712.0
TCGA-ZM-AA05-01A
36 years, male, white, stage:iic, alive, 1126 days
711.6
TCGA-2G-AAG9-01A
25 years, male, white, stage:iiib, alive, 2234 days
710.3
TCGA-2G-AAGF-01A
28 years, male, white, stage:is, alive, 2734 days
695.5
TCGA-XY-A8S2-01A
67 years, male, white, stage:i, alive, 672 days
686.0
TCGA-2G-AAFL-01A
35 years, male, white, stage:ib, alive, 750 days
681.9
TCGA-2G-AAG8-01A
21 years, male, white, stage:ib, alive, 2289 days
678.8
TCGA-XE-A8H5-01A
29 years, male, stage:is, alive, 1217 days
671.6
TCGA-S6-A8JW-01A
37 years, male, white, stage:is, alive, 698 days
669.5
TCGA-2G-AAHA-01A
48 years, male, white, stage:ib, alive, 3349 days
655.1
TCGA-YU-A912-01A
34 years, male, black or african american, stage:iiic, alive, 866 days
651.1
TCGA-2G-AAFG-01A
30 years, male, white, stage:is, alive, 6183 days
649.5
TCGA-2G-AAGV-01A
23 years, male, white, alive, 4527 days
648.8
TCGA-2G-AAFY-01A
24 years, male, white, stage:iia, alive, 1099 days
645.4
TCGA-YU-A90Y-01A
23 years, male, black or african american, stage:iiic, dead, 17 days
638.8
TCGA-2G-AAGN-01A
41 years, male, white, stage:iiib, alive, 3656 days
633.8
TCGA-2G-AAKG-01A
22 years, male, white, stage:i, alive, 6598 days
622.8
TCGA-2G-AAH3-01A
20 years, male, white, stage:i, alive, 1822 days
607.5
TCGA-2G-AAGE-01A
21 years, male, white, stage:is, alive, 2478 days
604.5
TCGA-XE-A8H1-01A
24 years, male, white, stage:is, alive, 209 days
601.5
TCGA-2G-AAKL-01A
26 years, male, white, stage:ii, alive, 7023 days
600.9
TCGA-2G-AAH0-01A
30 years, male, white, stage:is, alive, 5477 days
593.0
TCGA-W4-A7U4-01A
23 years, male, white, alive, 738 days
592.8
TCGA-ZM-AA0F-01A
35 years, male, white, stage:ia, alive, 681 days
589.0
TCGA-XE-AAOB-01A
27 years, male, white, stage:is, dead, 513 days
588.7
TCGA-XY-A9T9-01A
37 years, male, white, stage:is, alive, 281 days
585.7
TCGA-VF-A8AB-01A
31 years, male, black or african american, stage:ia, alive, 760 days
581.0
TCGA-2X-A9D5-01A
49 years, male, white, stage:i, alive, 435 days
576.0
TCGA-SN-A6IS-01A
26 years, male, white, stage:is, alive, 496 days
573.3
TCGA-XE-AAOJ-01A
24 years, male, white, stage:is, alive, 1550 days
555.5
TCGA-XE-AAOL-01A
38 years, male, black or african american, stage:i, alive, 13 days
554.8
TCGA-2G-AAGK-01A
20 years, male, white, stage:is, alive, 3621 days
546.2
TCGA-2G-AAGA-01A
38 years, male, white, stage:iia, alive, 2439 days
532.8
TCGA-2G-AALP-01A
43 years, male, white, stage:iiib, alive, 2645 days
522.9
TCGA-2G-AAH4-01A
34 years, male, white, stage:ii, alive, 6210 days
515.6
TCGA-2G-AAF1-01A
28 years, male, asian, stage:is, alive, 1403 days
512.5
TCGA-YU-AA4L-01A
27 years, male, black or african american, stage:iiic, alive, 1573 days
494.0
TCGA-2G-AAKH-01A
19 years, male, white, stage:ii, alive, 6862 days
493.5
TCGA-X3-A8G4-01A
33 years, male, white, stage:is, alive, 856 days
492.6
TCGA-2G-AAFJ-01A
23 years, male, asian, alive, 792 days
488.8
TCGA-YU-A90P-01A
25 years, male, white, stage:ia, alive, 2069 days
481.0
TCGA-2G-AAFI-01A
41 years, male, white, stage:ib, alive, 675 days
477.9
TCGA-WZ-A7V4-01A
28 years, male, white, stage:i, alive, 894 days
463.3
TCGA-WZ-A7V3-01A
20 years, male, white, stage:i, alive, 753 days
459.7
TCGA-VF-A8AD-01A
36 years, male, white, stage:ib, alive, 1006 days
456.9
TCGA-YU-AA61-01A
29 years, male, white, stage:is, alive, 864 days
450.0
TCGA-XY-A8S3-01B
24 years, male, white, stage:is, alive, 843 days
449.7
TCGA-2G-AAH2-01A
20 years, male, white, stage:is, alive, 6060 days
436.9
TCGA-2G-AAL5-01A
31 years, male, white, stage:i, alive, 7437 days
436.7
TCGA-SN-A84W-01A
30 years, male, white, stage:is, alive, 293 days
436.7
TCGA-2G-AAGX-01A
22 years, male, white, stage:ia, alive, 5514 days
434.1
TCGA-XE-AANI-01A
37 years, male, white, stage:is, alive, 1041 days
431.0
TCGA-2G-AAGJ-01A
28 years, male, black or african american, stage:ia, alive, 2938 days
426.0
TCGA-2G-AAGC-01A
28 years, male, white, stage:is, alive, 2585 days
422.0
TCGA-YU-A94D-01A
28 years, male, stage:iiib, alive, 2167 days
421.6
TCGA-2X-A9D6-01A
42 years, male, white, stage:i, alive, 607 days
416.4
TCGA-2G-AAKM-01A
14 years, male, white, stage:ii, dead, 6972 days
414.9
TCGA-2G-AAG5-01A
36 years, male, white, stage:is, alive, 2299 days
403.3
TCGA-2G-AAG6-01A
24 years, male, white, stage:is, alive, 2231 days
401.8
TCGA-2G-AAFZ-01A
32 years, male, white, stage:iii, alive, 1353 days
385.7
TCGA-2G-AAGT-01A
30 years, male, white, stage:is, alive, 4406 days
375.9
TCGA-2G-AAFV-01A
31 years, male, white, stage:is, alive, 1389 days
364.0
TCGA-2G-AAGG-01A
20 years, male, white, stage:iiic, alive, 2611 days
346.7
TCGA-2G-AAG0-01A
23 years, male, white, stage:is, alive, 1529 days
346.4
TCGA-2G-AAG7-01A
33 years, male, white, stage:is, alive, 2475 days
330.6
TCGA-W4-A7U3-01A
26 years, male, white, alive, 149 days
327.3
TCGA-2G-AAGM-01A
51 years, male, white, stage:is, alive, 3891 days
311.5
TCGA-2G-AAGI-01A
33 years, male, white, stage:is, alive, 3137 days
305.8
TCGA-2G-AAGP-01A
33 years, male, white, stage:iia, alive, 4018 days
298.2
TCGA-XE-AAOC-01A
31 years, male, white, stage:ia, alive, 270 days
296.4
TCGA-2G-AAGY-01A
28 years, male, white, stage:is, alive, 5329 days
289.1
TCGA-2G-AAGS-01A
39 years, male, white, stage:iiib, alive, 4816 days
281.0
TCGA-YU-A94I-01A
66 years, male, stage:ia, alive, 536 days
198.8
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TESTIS CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.