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FGF2
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  • FGF2
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

FGF2
Synonyms FGFB
Gene descriptioni

Full gene name according to HGNC.

Fibroblast growth factor 2
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Candidate cardiovascular disease genes
FDA approved drug targets
RAS pathway related proteins
Transporters
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular,Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 4
Cytoband q28.1
Chromosome location (bp) 122826708 - 122898236
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

3
Ensembl ENSG00000138685 (version 103.38)
Entrez gene 2247
HGNC HGNC:3676
UniProt P09038 (UniProt - Evidence at protein level)
neXtProt NX_P09038
Antibodypedia FGF2 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 170

Experimental

Description: THE 154 AMINO ACID FORM OF HUMAN BASIC FIBROBLAST GROWTH FACTOR (X-ray)

# Chains: 1      # Clinical variants: 0      # Population variants: 0

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
FGF2-201
FGF2-202
FGF2-203


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
FGF2-201
ENSP00000264498
ENST00000264498
A0A0A0MQV6 [Direct mapping]
Fibroblast growth factor
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0008083 [growth factor activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
288 aa
30.8 kDa
No 0
FGF2-202
ENSP00000477134
ENST00000608478
P09038 [Direct mapping]
Fibroblast growth factor 2
D9ZGF5 [Target identity:100%; Query identity:100%]
Fibroblast growth factor
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0001525 [angiogenesis]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005125 [cytokine activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006935 [chemotaxis]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organism development]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009887 [animal organ morphogenesis]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010764 [negative regulation of fibroblast migration]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014843 [growth factor dependent regulation of skeletal muscle satellite cell proliferation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019956 [chemokine binding]
GO:0030154 [cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0030214 [hyaluronan catabolic process]
GO:0030324 [lung development]
GO:0030334 [regulation of cell migration]
GO:0030374 [nuclear receptor transcription coactivator activity]
GO:0032958 [inositol phosphate biosynthetic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0038001 [paracrine signaling]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042060 [wound healing]
GO:0042660 [positive regulation of cell fate specification]
GO:0042802 [identical protein binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045765 [regulation of angiogenesis]
GO:0045766 [positive regulation of angiogenesis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048598 [embryonic morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050918 [positive chemotaxis]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051781 [positive regulation of cell division]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060548 [negative regulation of cell death]
GO:0060591 [chondroblast differentiation]
GO:0061045 [negative regulation of wound healing]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072089 [stem cell proliferation]
GO:0090049 [regulation of cell migration involved in sprouting angiogenesis]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090722 [receptor-receptor interaction]
GO:1902748 [positive regulation of lens fiber cell differentiation]
GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II]
GO:1903587 [regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation]
GO:1905278 [positive regulation of epithelial tube formation]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
GO:2000546 [positive regulation of endothelial cell chemotaxis to fibroblast growth factor]
GO:2000573 [positive regulation of DNA biosynthetic process]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
155 aa
17.3 kDa
No 0
FGF2-203
ENSP00000494222
ENST00000644866
P09038 [Direct mapping]
Fibroblast growth factor 2
D9ZGF5 [Target identity:100%; Query identity:100%]
Fibroblast growth factor
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0001525 [angiogenesis]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005125 [cytokine activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006935 [chemotaxis]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organism development]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009887 [animal organ morphogenesis]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010764 [negative regulation of fibroblast migration]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014843 [growth factor dependent regulation of skeletal muscle satellite cell proliferation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019956 [chemokine binding]
GO:0030154 [cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0030214 [hyaluronan catabolic process]
GO:0030324 [lung development]
GO:0030334 [regulation of cell migration]
GO:0030374 [nuclear receptor transcription coactivator activity]
GO:0032958 [inositol phosphate biosynthetic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0038001 [paracrine signaling]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042060 [wound healing]
GO:0042660 [positive regulation of cell fate specification]
GO:0042802 [identical protein binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045765 [regulation of angiogenesis]
GO:0045766 [positive regulation of angiogenesis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048598 [embryonic morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050918 [positive chemotaxis]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051781 [positive regulation of cell division]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060548 [negative regulation of cell death]
GO:0060591 [chondroblast differentiation]
GO:0061045 [negative regulation of wound healing]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072089 [stem cell proliferation]
GO:0090049 [regulation of cell migration involved in sprouting angiogenesis]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090722 [receptor-receptor interaction]
GO:1902748 [positive regulation of lens fiber cell differentiation]
GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II]
GO:1903587 [regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation]
GO:1905278 [positive regulation of epithelial tube formation]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
GO:2000546 [positive regulation of endothelial cell chemotaxis to fibroblast growth factor]
GO:2000573 [positive regulation of DNA biosynthetic process]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
155 aa
17.3 kDa
No 0

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The Human Protein Atlas

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.