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BMPR1B
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  • BMPR1B
PROTEIN STRUCTURE
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

BMPR1B
Synonyms ALK6, CDw293
Gene descriptioni

Full gene name according to HGNC.

Bone morphogenetic protein receptor type 1B
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
CD markers
Disease related genes
Enzymes
Human disease related genes
Potential drug targets
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular,Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 4
Cytoband q22.3
Chromosome location (bp) 94757955 - 95158448
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

8
Ensembl ENSG00000138696 (version 103.38)
Entrez gene 658
HGNC HGNC:1077
UniProt O00238 (UniProt - Evidence at protein level)
neXtProt NX_O00238
Antibodypedia BMPR1B antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 8      # Population variants: 317

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
BMPR1B-201
BMPR1B-202
BMPR1B-203
BMPR1B-205
BMPR1B-206
BMPR1B-207
BMPR1B-208
BMPR1B-209


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
BMPR1B-201
ENSP00000264568
ENST00000264568
O00238 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001550 [ovarian cumulus expansion]
GO:0001654 [eye development]
GO:0002063 [chondrocyte development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005025 [transforming growth factor beta receptor activity, type I]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009953 [dorsal/ventral pattern formation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0035108 [limb morphogenesis]
GO:0042698 [ovulation cycle]
GO:0043235 [receptor complex]
GO:0045597 [positive regulation of cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0051216 [cartilage development]
GO:0060350 [endochondral bone morphogenesis]
GO:0061036 [positive regulation of cartilage development]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071773 [cellular response to BMP stimulus]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1990712 [HFE-transferrin receptor complex]
Show all
502 aa
56.9 kDa
No 1
BMPR1B-202
ENSP00000378389
ENST00000394931
O00238 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001550 [ovarian cumulus expansion]
GO:0001654 [eye development]
GO:0002063 [chondrocyte development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005025 [transforming growth factor beta receptor activity, type I]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009953 [dorsal/ventral pattern formation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0035108 [limb morphogenesis]
GO:0042698 [ovulation cycle]
GO:0043235 [receptor complex]
GO:0045597 [positive regulation of cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0051216 [cartilage development]
GO:0060350 [endochondral bone morphogenesis]
GO:0061036 [positive regulation of cartilage development]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071773 [cellular response to BMP stimulus]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1990712 [HFE-transferrin receptor complex]
Show all
502 aa
56.9 kDa
No 1
BMPR1B-203
ENSP00000401907
ENST00000440890
O00238 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001550 [ovarian cumulus expansion]
GO:0001654 [eye development]
GO:0002062 [chondrocyte differentiation]
GO:0002063 [chondrocyte development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005025 [transforming growth factor beta receptor activity, type I]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009953 [dorsal/ventral pattern formation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0030154 [cell differentiation]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030425 [dendrite]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0031290 [retinal ganglion cell axon guidance]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0035108 [limb morphogenesis]
GO:0042698 [ovulation cycle]
GO:0043010 [camera-type eye development]
GO:0043025 [neuronal cell body]
GO:0043235 [receptor complex]
GO:0045597 [positive regulation of cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0051216 [cartilage development]
GO:0060041 [retina development in camera-type eye]
GO:0060350 [endochondral bone morphogenesis]
GO:0061036 [positive regulation of cartilage development]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071773 [cellular response to BMP stimulus]
GO:1902043 [positive regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1990712 [HFE-transferrin receptor complex]
Show all
532 aa
60.6 kDa
No 1
BMPR1B-205
ENSP00000421144
ENST00000506363
D6RGW8 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
Show all
GO:0000166 [nucleotide binding]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0016020 [membrane]
Show all
125 aa
13.9 kDa
No 0
BMPR1B-206
ENSP00000421671
ENST00000509540
O00238 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001550 [ovarian cumulus expansion]
GO:0001654 [eye development]
GO:0002063 [chondrocyte development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005025 [transforming growth factor beta receptor activity, type I]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009953 [dorsal/ventral pattern formation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0035108 [limb morphogenesis]
GO:0042698 [ovulation cycle]
GO:0043235 [receptor complex]
GO:0045597 [positive regulation of cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0051216 [cartilage development]
GO:0060350 [endochondral bone morphogenesis]
GO:0061036 [positive regulation of cartilage development]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071773 [cellular response to BMP stimulus]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1990712 [HFE-transferrin receptor complex]
Show all
502 aa
56.9 kDa
No 1
BMPR1B-207
ENSP00000425444
ENST00000512312
O00238 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001550 [ovarian cumulus expansion]
GO:0001654 [eye development]
GO:0002063 [chondrocyte development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005025 [transforming growth factor beta receptor activity, type I]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009953 [dorsal/ventral pattern formation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0035108 [limb morphogenesis]
GO:0042698 [ovulation cycle]
GO:0043235 [receptor complex]
GO:0045597 [positive regulation of cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0051216 [cartilage development]
GO:0060350 [endochondral bone morphogenesis]
GO:0061036 [positive regulation of cartilage development]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071773 [cellular response to BMP stimulus]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1990712 [HFE-transferrin receptor complex]
Show all
502 aa
56.9 kDa
No 1
BMPR1B-208
ENSP00000426617
ENST00000515059
O00238 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001550 [ovarian cumulus expansion]
GO:0001654 [eye development]
GO:0002063 [chondrocyte development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005025 [transforming growth factor beta receptor activity, type I]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009953 [dorsal/ventral pattern formation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0035108 [limb morphogenesis]
GO:0042698 [ovulation cycle]
GO:0043235 [receptor complex]
GO:0045597 [positive regulation of cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0051216 [cartilage development]
GO:0060350 [endochondral bone morphogenesis]
GO:0061036 [positive regulation of cartilage development]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071773 [cellular response to BMP stimulus]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1990712 [HFE-transferrin receptor complex]
Show all
502 aa
56.9 kDa
No 1
BMPR1B-209
ENSP00000500035
ENST00000672698
O00238 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001550 [ovarian cumulus expansion]
GO:0001654 [eye development]
GO:0002063 [chondrocyte development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005025 [transforming growth factor beta receptor activity, type I]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009953 [dorsal/ventral pattern formation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0035108 [limb morphogenesis]
GO:0042698 [ovulation cycle]
GO:0043235 [receptor complex]
GO:0045597 [positive regulation of cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0051216 [cartilage development]
GO:0060350 [endochondral bone morphogenesis]
GO:0061036 [positive regulation of cartilage development]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071773 [cellular response to BMP stimulus]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1990712 [HFE-transferrin receptor complex]
Show all
502 aa
56.9 kDa
No 1

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