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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q25
Chromosome location (bp)
108047545 - 108168956
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
LEF1-201
LEF1-202
LEF1-203
LEF1-216
LEF1-218
LEF1-221
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987 [cis-regulatory region sequence-specific DNA binding] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001649 [osteoblast differentiation] GO:0001756 [somitogenesis] GO:0001837 [epithelial to mesenchymal transition] GO:0001944 [vasculature development] GO:0002040 [sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007223 [Wnt signaling pathway, calcium modulating pathway] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008301 [DNA binding, bending] GO:0010628 [positive regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0016055 [Wnt signaling pathway] GO:0021542 [dentate gyrus development] GO:0021766 [hippocampus development] GO:0021861 [forebrain radial glial cell differentiation] GO:0021873 [forebrain neuroblast division] GO:0021943 [formation of radial glial scaffolds] GO:0022407 [regulation of cell-cell adhesion] GO:0030111 [regulation of Wnt signaling pathway] GO:0030223 [neutrophil differentiation] GO:0030284 [estrogen receptor activity] GO:0030326 [embryonic limb morphogenesis] GO:0030331 [estrogen receptor binding] GO:0030335 [positive regulation of cell migration] GO:0030509 [BMP signaling pathway] GO:0030854 [positive regulation of granulocyte differentiation] GO:0030879 [mammary gland development] GO:0032696 [negative regulation of interleukin-13 production] GO:0032713 [negative regulation of interleukin-4 production] GO:0032714 [negative regulation of interleukin-5 production] GO:0032993 [protein-DNA complex] GO:0033153 [T cell receptor V(D)J recombination] GO:0042100 [B cell proliferation] GO:0042393 [histone binding] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0042826 [histone deacetylase binding] GO:0043066 [negative regulation of apoptotic process] GO:0043392 [negative regulation of DNA binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0043586 [tongue development] GO:0043923 [positive regulation by host of viral transcription] GO:0043966 [histone H3 acetylation] GO:0043967 [histone H4 acetylation] GO:0045063 [T-helper 1 cell differentiation] GO:0045295 [gamma-catenin binding] GO:0045588 [positive regulation of gamma-delta T cell differentiation] GO:0045843 [negative regulation of striated muscle tissue development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046632 [alpha-beta T cell differentiation] GO:0048341 [paraxial mesoderm formation] GO:0048468 [cell development] GO:0050909 [sensory perception of taste] GO:0060033 [anatomical structure regression] GO:0060070 [canonical Wnt signaling pathway] GO:0060325 [face morphogenesis] GO:0060326 [cell chemotaxis] GO:0060561 [apoptotic process involved in morphogenesis] GO:0060710 [chorio-allantoic fusion] GO:0061153 [trachea gland development] GO:0062009 [secondary palate development] GO:0070016 [armadillo repeat domain binding] GO:0070742 [C2H2 zinc finger domain binding] GO:0071345 [cellular response to cytokine stimulus] GO:0071353 [cellular response to interleukin-4] GO:0071864 [positive regulation of cell proliferation in bone marrow] GO:0071866 [negative regulation of apoptotic process in bone marrow cell] GO:0071899 [negative regulation of estrogen receptor binding] GO:1902262 [apoptotic process involved in blood vessel morphogenesis] GO:1904837 [beta-catenin-TCF complex assembly] GO:1990837 [sequence-specific double-stranded DNA binding] GO:1990907 [beta-catenin-TCF complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001649 [osteoblast differentiation] GO:0001837 [epithelial to mesenchymal transition] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005737 [cytoplasm] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007223 [Wnt signaling pathway, calcium modulating pathway] GO:0008013 [beta-catenin binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008301 [DNA binding, bending] GO:0010628 [positive regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0016055 [Wnt signaling pathway] GO:0030223 [neutrophil differentiation] GO:0030284 [estrogen receptor activity] GO:0030331 [estrogen receptor binding] GO:0030335 [positive regulation of cell migration] GO:0030854 [positive regulation of granulocyte differentiation] GO:0032696 [negative regulation of interleukin-13 production] GO:0032713 [negative regulation of interleukin-4 production] GO:0032714 [negative regulation of interleukin-5 production] GO:0032993 [protein-DNA complex] GO:0042393 [histone binding] GO:0042826 [histone deacetylase binding] GO:0043066 [negative regulation of apoptotic process] GO:0043392 [negative regulation of DNA binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0043923 [positive regulation by host of viral transcription] GO:0043966 [histone H3 acetylation] GO:0043967 [histone H4 acetylation] GO:0045063 [T-helper 1 cell differentiation] GO:0045295 [gamma-catenin binding] GO:0045588 [positive regulation of gamma-delta T cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0060070 [canonical Wnt signaling pathway] GO:0060326 [cell chemotaxis] GO:0062009 [secondary palate development] GO:0070016 [armadillo repeat domain binding] GO:0070742 [C2H2 zinc finger domain binding] GO:0071345 [cellular response to cytokine stimulus] GO:0071353 [cellular response to interleukin-4] GO:0071864 [positive regulation of cell proliferation in bone marrow] GO:0071866 [negative regulation of apoptotic process in bone marrow cell] GO:0071899 [negative regulation of estrogen receptor binding] GO:1904837 [beta-catenin-TCF complex assembly] GO:1990837 [sequence-specific double-stranded DNA binding] GO:1990907 [beta-catenin-TCF complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001649 [osteoblast differentiation] GO:0001837 [epithelial to mesenchymal transition] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005737 [cytoplasm] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007223 [Wnt signaling pathway, calcium modulating pathway] GO:0008013 [beta-catenin binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008301 [DNA binding, bending] GO:0010628 [positive regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0016055 [Wnt signaling pathway] GO:0022408 [negative regulation of cell-cell adhesion] GO:0022409 [positive regulation of cell-cell adhesion] GO:0030223 [neutrophil differentiation] GO:0030284 [estrogen receptor activity] GO:0030331 [estrogen receptor binding] GO:0030335 [positive regulation of cell migration] GO:0030854 [positive regulation of granulocyte differentiation] GO:0032696 [negative regulation of interleukin-13 production] GO:0032713 [negative regulation of interleukin-4 production] GO:0032714 [negative regulation of interleukin-5 production] GO:0032993 [protein-DNA complex] GO:0042393 [histone binding] GO:0042826 [histone deacetylase binding] GO:0043066 [negative regulation of apoptotic process] GO:0043392 [negative regulation of DNA binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0043923 [positive regulation by host of viral transcription] GO:0043966 [histone H3 acetylation] GO:0043967 [histone H4 acetylation] GO:0045063 [T-helper 1 cell differentiation] GO:0045295 [gamma-catenin binding] GO:0045588 [positive regulation of gamma-delta T cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0060070 [canonical Wnt signaling pathway] GO:0060326 [cell chemotaxis] GO:0062009 [secondary palate development] GO:0070016 [armadillo repeat domain binding] GO:0070742 [C2H2 zinc finger domain binding] GO:0071345 [cellular response to cytokine stimulus] GO:0071353 [cellular response to interleukin-4] GO:0071864 [positive regulation of cell proliferation in bone marrow] GO:0071866 [negative regulation of apoptotic process in bone marrow cell] GO:0071899 [negative regulation of estrogen receptor binding] GO:0090068 [positive regulation of cell cycle process] GO:1904837 [beta-catenin-TCF complex assembly] GO:1990837 [sequence-specific double-stranded DNA binding] GO:1990907 [beta-catenin-TCF complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001649 [osteoblast differentiation] GO:0001837 [epithelial to mesenchymal transition] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005737 [cytoplasm] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007223 [Wnt signaling pathway, calcium modulating pathway] GO:0008013 [beta-catenin binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008301 [DNA binding, bending] GO:0010628 [positive regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0016055 [Wnt signaling pathway] GO:0030223 [neutrophil differentiation] GO:0030284 [estrogen receptor activity] GO:0030331 [estrogen receptor binding] GO:0030335 [positive regulation of cell migration] GO:0030854 [positive regulation of granulocyte differentiation] GO:0032696 [negative regulation of interleukin-13 production] GO:0032713 [negative regulation of interleukin-4 production] GO:0032714 [negative regulation of interleukin-5 production] GO:0032993 [protein-DNA complex] GO:0042393 [histone binding] GO:0042826 [histone deacetylase binding] GO:0043066 [negative regulation of apoptotic process] GO:0043392 [negative regulation of DNA binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0043923 [positive regulation by host of viral transcription] GO:0043966 [histone H3 acetylation] GO:0043967 [histone H4 acetylation] GO:0045063 [T-helper 1 cell differentiation] GO:0045295 [gamma-catenin binding] GO:0045588 [positive regulation of gamma-delta T cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0060070 [canonical Wnt signaling pathway] GO:0060326 [cell chemotaxis] GO:0062009 [secondary palate development] GO:0070016 [armadillo repeat domain binding] GO:0070742 [C2H2 zinc finger domain binding] GO:0071345 [cellular response to cytokine stimulus] GO:0071353 [cellular response to interleukin-4] GO:0071864 [positive regulation of cell proliferation in bone marrow] GO:0071866 [negative regulation of apoptotic process in bone marrow cell] GO:0071899 [negative regulation of estrogen receptor binding] GO:1904837 [beta-catenin-TCF complex assembly] GO:1990837 [sequence-specific double-stranded DNA binding] GO:1990907 [beta-catenin-TCF complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006357 [regulation of transcription by RNA polymerase II] GO:0008013 [beta-catenin binding] GO:0016055 [Wnt signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006357 [regulation of transcription by RNA polymerase II] GO:0008013 [beta-catenin binding] GO:0016055 [Wnt signaling pathway]