We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes FDA approved drug targets Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q25
Chromosome location (bp)
109912883 - 110013766
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
EGF-201
EGF-204
EGF-206
EGF-213
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Congenital disorders of metabolism Other congenital disorders of metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0001525 [angiogenesis] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005154 [epidermal growth factor receptor binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell population proliferation] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0021940 [positive regulation of cerebellar granule cell precursor proliferation] GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity] GO:0030335 [positive regulation of cell migration] GO:0030665 [clathrin-coated vesicle membrane] GO:0031093 [platelet alpha granule lumen] GO:0038029 [epidermal growth factor receptor signaling pathway via MAPK cascade] GO:0038128 [ERBB2 signaling pathway] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042327 [positive regulation of phosphorylation] GO:0043388 [positive regulation of DNA binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045740 [positive regulation of DNA replication] GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] GO:0045746 [negative regulation of Notch signaling pathway] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046425 [regulation of receptor signaling pathway via JAK-STAT] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051048 [negative regulation of secretion] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060749 [mammary gland alveolus development] GO:0061024 [membrane organization] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070062 [extracellular exosome] GO:0070371 [ERK1 and ERK2 cascade] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0090279 [regulation of calcium ion import] GO:0090370 [negative regulation of cholesterol efflux] GO:1900127 [positive regulation of hyaluronan biosynthetic process] GO:1901185 [negative regulation of ERBB signaling pathway] GO:1902966 [positive regulation of protein localization to early endosome] GO:1905278 [positive regulation of epithelial tube formation] GO:2000008 [regulation of protein localization to cell surface] GO:2000060 [positive regulation of ubiquitin-dependent protein catabolic process] GO:2000145 [regulation of cell motility]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Congenital disorders of metabolism Other congenital disorders of metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0001525 [angiogenesis] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005154 [epidermal growth factor receptor binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell population proliferation] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity] GO:0030335 [positive regulation of cell migration] GO:0030665 [clathrin-coated vesicle membrane] GO:0031093 [platelet alpha granule lumen] GO:0038029 [epidermal growth factor receptor signaling pathway via MAPK cascade] GO:0038128 [ERBB2 signaling pathway] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042327 [positive regulation of phosphorylation] GO:0043388 [positive regulation of DNA binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045740 [positive regulation of DNA replication] GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] GO:0045746 [negative regulation of Notch signaling pathway] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046425 [regulation of receptor signaling pathway via JAK-STAT] GO:0051048 [negative regulation of secretion] GO:0051897 [positive regulation of protein kinase B signaling] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0070371 [ERK1 and ERK2 cascade] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0090279 [regulation of calcium ion import] GO:1900127 [positive regulation of hyaluronan biosynthetic process] GO:1901185 [negative regulation of ERBB signaling pathway] GO:1902966 [positive regulation of protein localization to early endosome] GO:1905278 [positive regulation of epithelial tube formation] GO:2000008 [regulation of protein localization to cell surface] GO:2000145 [regulation of cell motility]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Congenital disorders of metabolism Other congenital disorders of metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0001525 [angiogenesis] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005154 [epidermal growth factor receptor binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell population proliferation] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity] GO:0030335 [positive regulation of cell migration] GO:0030665 [clathrin-coated vesicle membrane] GO:0031093 [platelet alpha granule lumen] GO:0038029 [epidermal growth factor receptor signaling pathway via MAPK cascade] GO:0038128 [ERBB2 signaling pathway] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042327 [positive regulation of phosphorylation] GO:0043388 [positive regulation of DNA binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045740 [positive regulation of DNA replication] GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] GO:0045746 [negative regulation of Notch signaling pathway] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046425 [regulation of receptor signaling pathway via JAK-STAT] GO:0051048 [negative regulation of secretion] GO:0051897 [positive regulation of protein kinase B signaling] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0070371 [ERK1 and ERK2 cascade] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0090279 [regulation of calcium ion import] GO:1900127 [positive regulation of hyaluronan biosynthetic process] GO:1901185 [negative regulation of ERBB signaling pathway] GO:1902966 [positive regulation of protein localization to early endosome] GO:1905278 [positive regulation of epithelial tube formation] GO:2000008 [regulation of protein localization to cell surface] GO:2000145 [regulation of cell motility]
The Human Protein Atlas project is funded
