GENERAL INFORMATIONi
Gene namei PML
Synonyms MYL, RNF71, TRIM19
Gene descriptioni PML nuclear body scaffold
Protein classi Cancer-related genes
Disease related genes
Human disease related genes
Plasma proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 15
Cytoband q24.1
Chromosome location (bp) 73994673 - 74047827
Number of transcriptsi 18
Ensembl ENSG00000140464 (version 103.38)
Entrez gene 5371
HGNC HGNC:9113
UniProt P29590 (UniProt - Evidence at protein level)
neXtProt NX_P29590
Antibodypedia PML antibodies


PROTEIN STRUCTUREi

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 572

Antigens:

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Variants:

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Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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PROTEIN BROWSERi
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PML-201
PML-202
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PML-204
PML-205
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PML-207
PML-208
PML-209
PML-210
PML-211
PML-213
PML-215
PML-216
PML-217
PML-218
PML-220
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PROTEIN INFORMATIONi
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
PML-201
ENSP00000268058
ENST00000268058
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0000792 [heterochromatin]
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006606 [protein import into nucleus]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007182 [common-partner SMAD protein phosphorylation]
GO:0007569 [cell aging]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress]
GO:0009411 [response to UV]
GO:0010332 [response to gamma radiation]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0010761 [fibroblast migration]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0030099 [myeloid cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032691 [negative regulation of interleukin-1 beta production]
GO:0032692 [negative regulation of interleukin-1 production]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060444 [branching involved in mammary gland duct morphogenesis]
GO:0065003 [protein-containing complex assembly]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0071353 [cellular response to interleukin-4]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090398 [cellular senescence]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0140037 [sumo-dependent protein binding]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902187 [negative regulation of viral release from host cell]
GO:1990830 [cellular response to leukemia inhibitory factor]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001235 [positive regulation of apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 882 aa
97.6 kDa 		No 0
PML-202
ENSP00000268059
ENST00000268059
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 [sumo-dependent protein binding]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 829 aa
90.7 kDa 		No 0
PML-203
ENSP00000315434
ENST00000354026
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 [sumo-dependent protein binding]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 781 aa
85.7 kDa 		No 0
PML-204
ENSP00000353004
ENST00000359928
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 [sumo-dependent protein binding]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 423 aa
47.6 kDa 		No 0
PML-205
ENSP00000378564
ENST00000395132
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 [sumo-dependent protein binding]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 435 aa
48.6 kDa 		No 0
PML-206
ENSP00000378567
ENST00000395135
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0050821 [protein stabilization]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 [sumo-dependent protein binding]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902187 [negative regulation of viral release from host cell]
GO:1904816 [positive regulation of protein localization to chromosome, telomeric region]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 633 aa
70 kDa 		No 0
PML-207
ENSP00000395576
ENST00000435786
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 [sumo-dependent protein binding]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 611 aa
67.5 kDa 		No 0
PML-208
ENSP00000394642
ENST00000436891
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 [sumo-dependent protein binding]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 560 aa
62 kDa 		No 0
PML-209
ENSP00000456329
ENST00000562086
H3BRN3 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Protein evidence (Ezkurdia et al 2014)
Show all
 110 aa
11.8 kDa 		No 0
PML-210
ENSP00000457032
ENST00000563500
H3BT57 [Direct mapping]
Protein PML
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
GO:0046872 [metal ion binding]
Show all
 568 aa
62.9 kDa 		No 0
PML-211
ENSP00000457023
ENST00000564428
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 [sumo-dependent protein binding]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 585 aa
65 kDa 		No 0
PML-213
ENSP00000456989
ENST00000565239
H3BT29 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Protein evidence (Ezkurdia et al 2014)
Show all
 240 aa
26.4 kDa 		No 0
PML-215
ENSP00000455838
ENST00000565898
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 [sumo-dependent protein binding]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 834 aa
92.6 kDa 		No 0
PML-216
ENSP00000458061
ENST00000566068
H3BVD2 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Protein evidence (Ezkurdia et al 2014)
Show all
 217 aa
23 kDa 		No 0
PML-217
ENSP00000456277
ENST00000567543
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 [sumo-dependent protein binding]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 423 aa
47.6 kDa 		No 0
PML-218
ENSP00000457669
ENST00000567606
H3BUJ5 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Protein evidence (Ezkurdia et al 2014)
Show all
 261 aa
28.7 kDa 		No 0
PML-220
ENSP00000455612
ENST00000569477
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 [sumo-dependent protein binding]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 641 aa
70.4 kDa 		No 0
PML-221
ENSP00000456486
ENST00000569965
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0032183 [SUMO binding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0065003 [protein-containing complex assembly]
GO:0090398 [cellular senescence]
GO:0140037 [sumo-dependent protein binding]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 560 aa
62 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.