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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Human disease related genes Plasma proteins Potential drug targets Transcription factors Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
p13.1
Chromosome location (bp)
7661779 - 7687538
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000733 [DNA strand renaturation] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987 [cis-regulatory region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001094 [TFIID-class transcription factor complex binding] GO:0001216 [DNA-binding transcription activator activity] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001701 [in utero embryonic development] GO:0001756 [somitogenesis] GO:0001836 [release of cytochrome c from mitochondria] GO:0002020 [protease binding] GO:0002039 [p53 binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0002309 [T cell proliferation involved in immune response] GO:0002326 [B cell lineage commitment] GO:0002360 [T cell lineage commitment] GO:0002931 [response to ischemia] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003730 [mRNA 3'-UTR binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005657 [replication fork] GO:0005667 [transcription regulator complex] GO:0005669 [transcription factor TFIID complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006289 [nucleotide-excision repair] GO:0006302 [double-strand break repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006606 [protein import into nucleus] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006979 [response to oxidative stress] GO:0006983 [ER overload response] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0007369 [gastrulation] GO:0007406 [negative regulation of neuroblast proliferation] GO:0007417 [central nervous system development] GO:0007507 [heart development] GO:0007569 [cell aging] GO:0007623 [circadian rhythm] GO:0008104 [protein localization] GO:0008134 [transcription factor binding] GO:0008156 [negative regulation of DNA replication] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell population proliferation] GO:0008340 [determination of adult lifespan] GO:0009299 [mRNA transcription] GO:0009303 [rRNA transcription] GO:0009411 [response to UV] GO:0009651 [response to salt stress] GO:0009792 [embryo development ending in birth or egg hatching] GO:0010165 [response to X-ray] GO:0010332 [response to gamma radiation] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010666 [positive regulation of cardiac muscle cell apoptotic process] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0021549 [cerebellum development] GO:0030308 [negative regulation of cell growth] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030971 [receptor tyrosine kinase binding] GO:0031065 [positive regulation of histone deacetylation] GO:0031497 [chromatin assembly] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0032991 [protein-containing complex] GO:0033077 [T cell differentiation in thymus] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034103 [regulation of tissue remodeling] GO:0034644 [cellular response to UV] GO:0035033 [histone deacetylase regulator activity] GO:0035035 [histone acetyltransferase binding] GO:0035264 [multicellular organism growth] GO:0035690 [cellular response to drug] GO:0035794 [positive regulation of mitochondrial membrane permeability] GO:0035861 [site of double-strand break] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0042127 [regulation of cell population proliferation] GO:0042149 [cellular response to glucose starvation] GO:0042493 [response to drug] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043504 [mitochondrial DNA repair] GO:0043516 [regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043523 [regulation of neuron apoptotic process] GO:0043525 [positive regulation of neuron apoptotic process] GO:0043621 [protein self-association] GO:0045861 [negative regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048511 [rhythmic process] GO:0048512 [circadian behavior] GO:0048539 [bone marrow development] GO:0048568 [embryonic organ development] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050821 [protein stabilization] GO:0051087 [chaperone binding] GO:0051097 [negative regulation of helicase activity] GO:0051262 [protein tetramerization] GO:0051276 [chromosome organization] GO:0051402 [neuron apoptotic process] GO:0051721 [protein phosphatase 2A binding] GO:0051726 [regulation of cell cycle] GO:0051974 [negative regulation of telomerase activity] GO:0060218 [hematopoietic stem cell differentiation] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060411 [cardiac septum morphogenesis] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0062100 [positive regulation of programmed necrotic cell death] GO:0065003 [protein-containing complex assembly] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070243 [regulation of thymocyte apoptotic process] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0070266 [necroptotic process] GO:0071158 [positive regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071479 [cellular response to ionizing radiation] GO:0071480 [cellular response to gamma radiation] GO:0071494 [cellular response to UV-C] GO:0071850 [mitotic cell cycle arrest] GO:0072331 [signal transduction by p53 class mediator] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717 [cellular response to actinomycin D] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090343 [positive regulation of cell aging] GO:0090399 [replicative senescence] GO:0090403 [oxidative stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097252 [oligodendrocyte apoptotic process] GO:0097371 [MDM2/MDM4 family protein binding] GO:0097718 [disordered domain specific binding] GO:1900119 [positive regulation of execution phase of apoptosis] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901525 [negative regulation of mitophagy] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1902108 [regulation of mitochondrial membrane permeability involved in apoptotic process] GO:1902253 [regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903799 [negative regulation of production of miRNAs involved in gene silencing by miRNA] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1904024 [negative regulation of glucose catabolic process to lactate via pyruvate] GO:1905856 [negative regulation of pentose-phosphate shunt] GO:1990144 [intrinsic apoptotic signaling pathway in response to hypoxia] GO:1990248 [regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841 [promoter-specific chromatin binding] GO:2000269 [regulation of fibroblast apoptotic process] GO:2000378 [negative regulation of reactive oxygen species metabolic process] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2000772 [regulation of cellular senescence] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000733 [DNA strand renaturation] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987 [cis-regulatory region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001094 [TFIID-class transcription factor complex binding] GO:0001216 [DNA-binding transcription activator activity] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020 [protease binding] GO:0002039 [p53 binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003730 [mRNA 3'-UTR binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005669 [transcription factor TFIID complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983 [ER overload response] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007569 [cell aging] GO:0008104 [protein localization] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell population proliferation] GO:0008340 [determination of adult lifespan] GO:0009299 [mRNA transcription] GO:0010332 [response to gamma radiation] GO:0010628 [positive regulation of gene expression] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0030971 [receptor tyrosine kinase binding] GO:0031497 [chromatin assembly] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034644 [cellular response to UV] GO:0035035 [histone acetyltransferase binding] GO:0035690 [cellular response to drug] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0042149 [cellular response to glucose starvation] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043621 [protein self-association] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048511 [rhythmic process] GO:0048512 [circadian behavior] GO:0048539 [bone marrow development] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087 [chaperone binding] GO:0051097 [negative regulation of helicase activity] GO:0051262 [protein tetramerization] GO:0051721 [protein phosphatase 2A binding] GO:0051974 [negative regulation of telomerase activity] GO:0060218 [hematopoietic stem cell differentiation] GO:0065003 [protein-containing complex assembly] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0071158 [positive regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071479 [cellular response to ionizing radiation] GO:0071480 [cellular response to gamma radiation] GO:0072331 [signal transduction by p53 class mediator] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717 [cellular response to actinomycin D] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090399 [replicative senescence] GO:0090403 [oxidative stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097252 [oligodendrocyte apoptotic process] GO:0097718 [disordered domain specific binding] GO:1900119 [positive regulation of execution phase of apoptosis] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905856 [negative regulation of pentose-phosphate shunt] GO:1990248 [regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841 [promoter-specific chromatin binding] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000733 [DNA strand renaturation] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987 [cis-regulatory region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001094 [TFIID-class transcription factor complex binding] GO:0001216 [DNA-binding transcription activator activity] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020 [protease binding] GO:0002039 [p53 binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003730 [mRNA 3'-UTR binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005669 [transcription factor TFIID complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983 [ER overload response] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007569 [cell aging] GO:0008104 [protein localization] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell population proliferation] GO:0008340 [determination of adult lifespan] GO:0009299 [mRNA transcription] GO:0010332 [response to gamma radiation] GO:0010628 [positive regulation of gene expression] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0030971 [receptor tyrosine kinase binding] GO:0031497 [chromatin assembly] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034644 [cellular response to UV] GO:0035035 [histone acetyltransferase binding] GO:0035690 [cellular response to drug] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0042149 [cellular response to glucose starvation] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043621 [protein self-association] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048511 [rhythmic process] GO:0048512 [circadian behavior] GO:0048539 [bone marrow development] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087 [chaperone binding] GO:0051097 [negative regulation of helicase activity] GO:0051262 [protein tetramerization] GO:0051721 [protein phosphatase 2A binding] GO:0051974 [negative regulation of telomerase activity] GO:0060218 [hematopoietic stem cell differentiation] GO:0065003 [protein-containing complex assembly] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0071158 [positive regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071479 [cellular response to ionizing radiation] GO:0071480 [cellular response to gamma radiation] GO:0072331 [signal transduction by p53 class mediator] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717 [cellular response to actinomycin D] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090399 [replicative senescence] GO:0090403 [oxidative stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097252 [oligodendrocyte apoptotic process] GO:0097718 [disordered domain specific binding] GO:1900119 [positive regulation of execution phase of apoptosis] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905856 [negative regulation of pentose-phosphate shunt] GO:1990248 [regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841 [promoter-specific chromatin binding] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000733 [DNA strand renaturation] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987 [cis-regulatory region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001094 [TFIID-class transcription factor complex binding] GO:0001216 [DNA-binding transcription activator activity] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020 [protease binding] GO:0002039 [p53 binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003730 [mRNA 3'-UTR binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005669 [transcription factor TFIID complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983 [ER overload response] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007569 [cell aging] GO:0008104 [protein localization] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell population proliferation] GO:0008340 [determination of adult lifespan] GO:0009299 [mRNA transcription] GO:0010332 [response to gamma radiation] GO:0010628 [positive regulation of gene expression] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0030971 [receptor tyrosine kinase binding] GO:0031497 [chromatin assembly] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034644 [cellular response to UV] GO:0035035 [histone acetyltransferase binding] GO:0035690 [cellular response to drug] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0042149 [cellular response to glucose starvation] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043621 [protein self-association] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048511 [rhythmic process] GO:0048512 [circadian behavior] GO:0048539 [bone marrow development] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087 [chaperone binding] GO:0051097 [negative regulation of helicase activity] GO:0051262 [protein tetramerization] GO:0051721 [protein phosphatase 2A binding] GO:0051974 [negative regulation of telomerase activity] GO:0060218 [hematopoietic stem cell differentiation] GO:0065003 [protein-containing complex assembly] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0071158 [positive regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071479 [cellular response to ionizing radiation] GO:0071480 [cellular response to gamma radiation] GO:0072331 [signal transduction by p53 class mediator] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717 [cellular response to actinomycin D] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090399 [replicative senescence] GO:0090403 [oxidative stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097252 [oligodendrocyte apoptotic process] GO:0097718 [disordered domain specific binding] GO:1900119 [positive regulation of execution phase of apoptosis] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905856 [negative regulation of pentose-phosphate shunt] GO:1990248 [regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841 [promoter-specific chromatin binding] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000733 [DNA strand renaturation] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987 [cis-regulatory region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001094 [TFIID-class transcription factor complex binding] GO:0001216 [DNA-binding transcription activator activity] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020 [protease binding] GO:0002039 [p53 binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003730 [mRNA 3'-UTR binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005669 [transcription factor TFIID complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983 [ER overload response] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007569 [cell aging] GO:0008104 [protein localization] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell population proliferation] GO:0008340 [determination of adult lifespan] GO:0009299 [mRNA transcription] GO:0010332 [response to gamma radiation] GO:0010628 [positive regulation of gene expression] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0030971 [receptor tyrosine kinase binding] GO:0031497 [chromatin assembly] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034644 [cellular response to UV] GO:0035035 [histone acetyltransferase binding] GO:0035690 [cellular response to drug] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0042149 [cellular response to glucose starvation] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043621 [protein self-association] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048511 [rhythmic process] GO:0048512 [circadian behavior] GO:0048539 [bone marrow development] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087 [chaperone binding] GO:0051097 [negative regulation of helicase activity] GO:0051262 [protein tetramerization] GO:0051721 [protein phosphatase 2A binding] GO:0051974 [negative regulation of telomerase activity] GO:0060218 [hematopoietic stem cell differentiation] GO:0065003 [protein-containing complex assembly] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0071158 [positive regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071479 [cellular response to ionizing radiation] GO:0071480 [cellular response to gamma radiation] GO:0072331 [signal transduction by p53 class mediator] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717 [cellular response to actinomycin D] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090399 [replicative senescence] GO:0090403 [oxidative stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097252 [oligodendrocyte apoptotic process] GO:0097718 [disordered domain specific binding] GO:1900119 [positive regulation of execution phase of apoptosis] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905856 [negative regulation of pentose-phosphate shunt] GO:1990248 [regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841 [promoter-specific chromatin binding] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000733 [DNA strand renaturation] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987 [cis-regulatory region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001094 [TFIID-class transcription factor complex binding] GO:0001216 [DNA-binding transcription activator activity] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020 [protease binding] GO:0002039 [p53 binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003730 [mRNA 3'-UTR binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005669 [transcription factor TFIID complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983 [ER overload response] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007569 [cell aging] GO:0008104 [protein localization] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell population proliferation] GO:0008340 [determination of adult lifespan] GO:0009299 [mRNA transcription] GO:0010332 [response to gamma radiation] GO:0010628 [positive regulation of gene expression] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0030971 [receptor tyrosine kinase binding] GO:0031497 [chromatin assembly] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034644 [cellular response to UV] GO:0035035 [histone acetyltransferase binding] GO:0035690 [cellular response to drug] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0042149 [cellular response to glucose starvation] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043621 [protein self-association] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048511 [rhythmic process] GO:0048512 [circadian behavior] GO:0048539 [bone marrow development] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087 [chaperone binding] GO:0051097 [negative regulation of helicase activity] GO:0051262 [protein tetramerization] GO:0051721 [protein phosphatase 2A binding] GO:0051974 [negative regulation of telomerase activity] GO:0060218 [hematopoietic stem cell differentiation] GO:0065003 [protein-containing complex assembly] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0071158 [positive regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071479 [cellular response to ionizing radiation] GO:0071480 [cellular response to gamma radiation] GO:0072331 [signal transduction by p53 class mediator] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717 [cellular response to actinomycin D] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090399 [replicative senescence] GO:0090403 [oxidative stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097252 [oligodendrocyte apoptotic process] GO:0097718 [disordered domain specific binding] GO:1900119 [positive regulation of execution phase of apoptosis] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905856 [negative regulation of pentose-phosphate shunt] GO:1990248 [regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841 [promoter-specific chromatin binding] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000733 [DNA strand renaturation] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987 [cis-regulatory region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001094 [TFIID-class transcription factor complex binding] GO:0001216 [DNA-binding transcription activator activity] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020 [protease binding] GO:0002039 [p53 binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003730 [mRNA 3'-UTR binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005669 [transcription factor TFIID complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983 [ER overload response] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007569 [cell aging] GO:0008104 [protein localization] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell population proliferation] GO:0008340 [determination of adult lifespan] GO:0009299 [mRNA transcription] GO:0010332 [response to gamma radiation] GO:0010628 [positive regulation of gene expression] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0030971 [receptor tyrosine kinase binding] GO:0031497 [chromatin assembly] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034644 [cellular response to UV] GO:0035035 [histone acetyltransferase binding] GO:0035690 [cellular response to drug] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0042149 [cellular response to glucose starvation] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043621 [protein self-association] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048511 [rhythmic process] GO:0048512 [circadian behavior] GO:0048539 [bone marrow development] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087 [chaperone binding] GO:0051097 [negative regulation of helicase activity] GO:0051262 [protein tetramerization] GO:0051721 [protein phosphatase 2A binding] GO:0051974 [negative regulation of telomerase activity] GO:0060218 [hematopoietic stem cell differentiation] GO:0065003 [protein-containing complex assembly] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0071158 [positive regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071479 [cellular response to ionizing radiation] GO:0071480 [cellular response to gamma radiation] GO:0072331 [signal transduction by p53 class mediator] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717 [cellular response to actinomycin D] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090399 [replicative senescence] GO:0090403 [oxidative stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097252 [oligodendrocyte apoptotic process] GO:0097718 [disordered domain specific binding] GO:1900119 [positive regulation of execution phase of apoptosis] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905856 [negative regulation of pentose-phosphate shunt] GO:1990248 [regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841 [promoter-specific chromatin binding] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000733 [DNA strand renaturation] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987 [cis-regulatory region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001094 [TFIID-class transcription factor complex binding] GO:0001216 [DNA-binding transcription activator activity] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020 [protease binding] GO:0002039 [p53 binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003730 [mRNA 3'-UTR binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005669 [transcription factor TFIID complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983 [ER overload response] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007569 [cell aging] GO:0008104 [protein localization] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell population proliferation] GO:0008340 [determination of adult lifespan] GO:0009299 [mRNA transcription] GO:0010332 [response to gamma radiation] GO:0010628 [positive regulation of gene expression] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0030971 [receptor tyrosine kinase binding] GO:0031497 [chromatin assembly] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034613 [cellular protein localization] GO:0034644 [cellular response to UV] GO:0035035 [histone acetyltransferase binding] GO:0035690 [cellular response to drug] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0042149 [cellular response to glucose starvation] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043621 [protein self-association] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048511 [rhythmic process] GO:0048512 [circadian behavior] GO:0048539 [bone marrow development] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087 [chaperone binding] GO:0051097 [negative regulation of helicase activity] GO:0051262 [protein tetramerization] GO:0051721 [protein phosphatase 2A binding] GO:0051974 [negative regulation of telomerase activity] GO:0060218 [hematopoietic stem cell differentiation] GO:0065003 [protein-containing complex assembly] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0071158 [positive regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071479 [cellular response to ionizing radiation] GO:0071480 [cellular response to gamma radiation] GO:0072331 [signal transduction by p53 class mediator] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717 [cellular response to actinomycin D] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090399 [replicative senescence] GO:0090403 [oxidative stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097252 [oligodendrocyte apoptotic process] GO:0097718 [disordered domain specific binding] GO:1900119 [positive regulation of execution phase of apoptosis] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905856 [negative regulation of pentose-phosphate shunt] GO:1990248 [regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841 [promoter-specific chromatin binding] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000733 [DNA strand renaturation] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987 [cis-regulatory region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001094 [TFIID-class transcription factor complex binding] GO:0001216 [DNA-binding transcription activator activity] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020 [protease binding] GO:0002039 [p53 binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003730 [mRNA 3'-UTR binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005669 [transcription factor TFIID complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983 [ER overload response] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007569 [cell aging] GO:0008104 [protein localization] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell population proliferation] GO:0008340 [determination of adult lifespan] GO:0009299 [mRNA transcription] GO:0010332 [response to gamma radiation] GO:0010628 [positive regulation of gene expression] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0030971 [receptor tyrosine kinase binding] GO:0031497 [chromatin assembly] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034644 [cellular response to UV] GO:0035035 [histone acetyltransferase binding] GO:0035690 [cellular response to drug] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0042149 [cellular response to glucose starvation] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043621 [protein self-association] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048511 [rhythmic process] GO:0048512 [circadian behavior] GO:0048539 [bone marrow development] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087 [chaperone binding] GO:0051097 [negative regulation of helicase activity] GO:0051262 [protein tetramerization] GO:0051721 [protein phosphatase 2A binding] GO:0051974 [negative regulation of telomerase activity] GO:0060218 [hematopoietic stem cell differentiation] GO:0065003 [protein-containing complex assembly] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0071158 [positive regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071479 [cellular response to ionizing radiation] GO:0071480 [cellular response to gamma radiation] GO:0072331 [signal transduction by p53 class mediator] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717 [cellular response to actinomycin D] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090399 [replicative senescence] GO:0090403 [oxidative stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097252 [oligodendrocyte apoptotic process] GO:0097718 [disordered domain specific binding] GO:1900119 [positive regulation of execution phase of apoptosis] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905856 [negative regulation of pentose-phosphate shunt] GO:1990248 [regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841 [promoter-specific chromatin binding] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000733 [DNA strand renaturation] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987 [cis-regulatory region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001094 [TFIID-class transcription factor complex binding] GO:0001216 [DNA-binding transcription activator activity] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020 [protease binding] GO:0002039 [p53 binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003730 [mRNA 3'-UTR binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005669 [transcription factor TFIID complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983 [ER overload response] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007569 [cell aging] GO:0008104 [protein localization] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell population proliferation] GO:0008340 [determination of adult lifespan] GO:0009299 [mRNA transcription] GO:0010332 [response to gamma radiation] GO:0010628 [positive regulation of gene expression] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0030971 [receptor tyrosine kinase binding] GO:0031497 [chromatin assembly] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034613 [cellular protein localization] GO:0034644 [cellular response to UV] GO:0035035 [histone acetyltransferase binding] GO:0035690 [cellular response to drug] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0042149 [cellular response to glucose starvation] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043621 [protein self-association] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048511 [rhythmic process] GO:0048512 [circadian behavior] GO:0048539 [bone marrow development] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087 [chaperone binding] GO:0051097 [negative regulation of helicase activity] GO:0051262 [protein tetramerization] GO:0051721 [protein phosphatase 2A binding] GO:0051974 [negative regulation of telomerase activity] GO:0060218 [hematopoietic stem cell differentiation] GO:0065003 [protein-containing complex assembly] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0071158 [positive regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071479 [cellular response to ionizing radiation] GO:0071480 [cellular response to gamma radiation] GO:0072331 [signal transduction by p53 class mediator] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717 [cellular response to actinomycin D] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090399 [replicative senescence] GO:0090403 [oxidative stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097252 [oligodendrocyte apoptotic process] GO:0097718 [disordered domain specific binding] GO:1900119 [positive regulation of execution phase of apoptosis] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905856 [negative regulation of pentose-phosphate shunt] GO:1990248 [regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841 [promoter-specific chromatin binding] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000733 [DNA strand renaturation] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987 [cis-regulatory region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001094 [TFIID-class transcription factor complex binding] GO:0001216 [DNA-binding transcription activator activity] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020 [protease binding] GO:0002039 [p53 binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003730 [mRNA 3'-UTR binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005669 [transcription factor TFIID complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983 [ER overload response] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007569 [cell aging] GO:0008104 [protein localization] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell population proliferation] GO:0008340 [determination of adult lifespan] GO:0009299 [mRNA transcription] GO:0010332 [response to gamma radiation] GO:0010628 [positive regulation of gene expression] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0030971 [receptor tyrosine kinase binding] GO:0031497 [chromatin assembly] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034613 [cellular protein localization] GO:0034644 [cellular response to UV] GO:0035035 [histone acetyltransferase binding] GO:0035690 [cellular response to drug] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0042149 [cellular response to glucose starvation] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043621 [protein self-association] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048511 [rhythmic process] GO:0048512 [circadian behavior] GO:0048539 [bone marrow development] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087 [chaperone binding] GO:0051097 [negative regulation of helicase activity] GO:0051262 [protein tetramerization] GO:0051721 [protein phosphatase 2A binding] GO:0051974 [negative regulation of telomerase activity] GO:0060218 [hematopoietic stem cell differentiation] GO:0065003 [protein-containing complex assembly] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0071158 [positive regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071479 [cellular response to ionizing radiation] GO:0071480 [cellular response to gamma radiation] GO:0072331 [signal transduction by p53 class mediator] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717 [cellular response to actinomycin D] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090399 [replicative senescence] GO:0090403 [oxidative stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097252 [oligodendrocyte apoptotic process] GO:0097718 [disordered domain specific binding] GO:1900119 [positive regulation of execution phase of apoptosis] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905856 [negative regulation of pentose-phosphate shunt] GO:1990248 [regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841 [promoter-specific chromatin binding] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of endocrine organs Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Nervous system diseases Other nervous and sensory system diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000733 [DNA strand renaturation] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987 [cis-regulatory region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001094 [TFIID-class transcription factor complex binding] GO:0001216 [DNA-binding transcription activator activity] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002020 [protease binding] GO:0002039 [p53 binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003730 [mRNA 3'-UTR binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005669 [transcription factor TFIID complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005783 [endoplasmic reticulum] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006289 [nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0006983 [ER overload response] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007569 [cell aging] GO:0008104 [protein localization] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell population proliferation] GO:0008340 [determination of adult lifespan] GO:0009299 [mRNA transcription] GO:0010332 [response to gamma radiation] GO:0010628 [positive regulation of gene expression] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0030971 [receptor tyrosine kinase binding] GO:0031497 [chromatin assembly] GO:0031571 [mitotic G1 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034644 [cellular response to UV] GO:0035035 [histone acetyltransferase binding] GO:0035690 [cellular response to drug] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0042149 [cellular response to glucose starvation] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043621 [protein self-association] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048511 [rhythmic process] GO:0048512 [circadian behavior] GO:0048539 [bone marrow development] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051087 [chaperone binding] GO:0051097 [negative regulation of helicase activity] GO:0051262 [protein tetramerization] GO:0051721 [protein phosphatase 2A binding] GO:0051974 [negative regulation of telomerase activity] GO:0060218 [hematopoietic stem cell differentiation] GO:0065003 [protein-containing complex assembly] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0071158 [positive regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071479 [cellular response to ionizing radiation] GO:0071480 [cellular response to gamma radiation] GO:0072331 [signal transduction by p53 class mediator] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072717 [cellular response to actinomycin D] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090399 [replicative senescence] GO:0090403 [oxidative stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097252 [oligodendrocyte apoptotic process] GO:0097718 [disordered domain specific binding] GO:1900119 [positive regulation of execution phase of apoptosis] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1902749 [regulation of cell cycle G2/M phase transition] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905856 [negative regulation of pentose-phosphate shunt] GO:1990248 [regulation of transcription from RNA polymerase II promoter in response to DNA damage] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990841 [promoter-specific chromatin binding] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
