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APP
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  • TISSUE

  • BRAIN

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  • TISSUE CELL

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  • APP
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

APP
Synonyms AD1
Gene descriptioni

Full gene name according to HGNC.

Amyloid beta precursor protein
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Disease related genes
FDA approved drug targets
Human disease related genes
Plasma proteins
Transporters
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular,Membrane,Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 21
Cytoband q21.3
Chromosome location (bp) 25880550 - 26171128
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

10
Ensembl ENSG00000142192 (version 103.38)
Entrez gene 351
HGNC HGNC:620
UniProt P05067 (UniProt - Evidence at protein level)
neXtProt NX_P05067
Antibodypedia APP antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 20      # Population variants: 429

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
APP-201
APP-202
APP-203
APP-204
APP-205
APP-206
APP-207
APP-208
APP-209
APP-210


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
APP-201
ENSP00000284981
ENST00000346798
P05067 [Direct mapping]
Amyloid-beta precursor protein N-APP Soluble APP-alpha Soluble APP-beta C99 Amyloid-beta protein 42 Amyloid-beta protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragment 50 C31
A0A140VJC8 [Target identity:100%; Query identity:100%]
ABPP
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Predicted secreted proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001774 [microglial cell activation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001967 [suckling behavior]
GO:0002265 [astrocyte activation involved in immune response]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005791 [rough endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005796 [Golgi lumen]
GO:0005798 [Golgi-associated vesicle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0005911 [cell-cell junction]
GO:0006378 [mRNA polyadenylation]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006878 [cellular copper ion homeostasis]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0006979 [response to oxidative stress]
GO:0007155 [cell adhesion]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007399 [nervous system development]
GO:0007409 [axonogenesis]
GO:0007611 [learning or memory]
GO:0007612 [learning]
GO:0007617 [mating behavior]
GO:0007626 [locomotory behavior]
GO:0008021 [synaptic vesicle]
GO:0008088 [axo-dendritic transport]
GO:0008201 [heparin binding]
GO:0008203 [cholesterol metabolic process]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008344 [adult locomotory behavior]
GO:0008542 [visual learning]
GO:0009314 [response to radiation]
GO:0009986 [cell surface]
GO:0009987 [cellular process]
GO:0010288 [response to lead ion]
GO:0010466 [negative regulation of peptidase activity]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010952 [positive regulation of peptidase activity]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0014005 [microglia development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016199 [axon midline choice point recognition]
GO:0016322 [neuron remodeling]
GO:0016358 [dendrite development]
GO:0016504 [peptidase activator activity]
GO:0019899 [enzyme binding]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0030134 [COPII-coated ER to Golgi transport vesicle]
GO:0030198 [extracellular matrix organization]
GO:0030414 [peptidase inhibitor activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030546 [signaling receptor activator activity]
GO:0030900 [forebrain development]
GO:0031093 [platelet alpha granule lumen]
GO:0031175 [neuron projection development]
GO:0031410 [cytoplasmic vesicle]
GO:0031594 [neuromuscular junction]
GO:0031904 [endosome lumen]
GO:0032092 [positive regulation of protein binding]
GO:0032588 [trans-Golgi network membrane]
GO:0032722 [positive regulation of chemokine production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035253 [ciliary rootlet]
GO:0040014 [regulation of multicellular organism growth]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043204 [perikaryon]
GO:0043235 [receptor complex]
GO:0043393 [regulation of protein binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044304 [main axon]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045177 [apical part of cell]
GO:0045202 [synapse]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045821 [positive regulation of glycolytic process]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0046914 [transition metal ion binding]
GO:0048143 [astrocyte activation]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048669 [collateral sprouting in absence of injury]
GO:0048786 [presynaptic active zone]
GO:0050729 [positive regulation of inflammatory response]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050803 [regulation of synapse structure or activity]
GO:0050808 [synapse organization]
GO:0050885 [neuromuscular process controlling balance]
GO:0050890 [cognition]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051124 [synaptic growth at neuromuscular junction]
GO:0051233 [spindle midzone]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051402 [neuron apoptotic process]
GO:0051425 [PTB domain binding]
GO:0051563 [smooth endoplasmic reticulum calcium ion homeostasis]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070555 [response to interleukin-1]
GO:0070851 [growth factor receptor binding]
GO:0071280 [cellular response to copper ion]
GO:0071287 [cellular response to manganese ion]
GO:0071320 [cellular response to cAMP]
GO:0071874 [cellular response to norepinephrine stimulus]
GO:0090647 [modulation of age-related behavioral decline]
GO:0097449 [astrocyte projection]
GO:0098815 [modulation of excitatory postsynaptic potential]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:1900272 [negative regulation of long-term synaptic potentiation]
GO:1900273 [positive regulation of long-term synaptic potentiation]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1904646 [cellular response to amyloid-beta]
GO:1905606 [regulation of presynapse assembly]
GO:1905908 [positive regulation of amyloid fibril formation]
GO:1990000 [amyloid fibril formation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990535 [neuron projection maintenance]
GO:1990761 [growth cone lamellipodium]
GO:1990812 [growth cone filopodium]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000406 [positive regulation of T cell migration]
Show all
770 aa
86.9 kDa
Yes 1
APP-202
ENSP00000345463
ENST00000348990
P05067 [Direct mapping]
Amyloid-beta precursor protein N-APP Soluble APP-alpha Soluble APP-beta C99 Amyloid-beta protein 42 Amyloid-beta protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragment 50 C31
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Predicted secreted proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001774 [microglial cell activation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002265 [astrocyte activation involved in immune response]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005796 [Golgi lumen]
GO:0005798 [Golgi-associated vesicle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006378 [mRNA polyadenylation]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006878 [cellular copper ion homeostasis]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0007155 [cell adhesion]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007399 [nervous system development]
GO:0007409 [axonogenesis]
GO:0007611 [learning or memory]
GO:0007612 [learning]
GO:0007617 [mating behavior]
GO:0007626 [locomotory behavior]
GO:0008088 [axo-dendritic transport]
GO:0008201 [heparin binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008344 [adult locomotory behavior]
GO:0008542 [visual learning]
GO:0009986 [cell surface]
GO:0009987 [cellular process]
GO:0010466 [negative regulation of peptidase activity]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010952 [positive regulation of peptidase activity]
GO:0014005 [microglia development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016199 [axon midline choice point recognition]
GO:0016322 [neuron remodeling]
GO:0016358 [dendrite development]
GO:0019899 [enzyme binding]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0030198 [extracellular matrix organization]
GO:0030414 [peptidase inhibitor activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031093 [platelet alpha granule lumen]
GO:0031175 [neuron projection development]
GO:0031410 [cytoplasmic vesicle]
GO:0031904 [endosome lumen]
GO:0032092 [positive regulation of protein binding]
GO:0032588 [trans-Golgi network membrane]
GO:0032722 [positive regulation of chemokine production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043204 [perikaryon]
GO:0043235 [receptor complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045821 [positive regulation of glycolytic process]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0046914 [transition metal ion binding]
GO:0048143 [astrocyte activation]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048669 [collateral sprouting in absence of injury]
GO:0050729 [positive regulation of inflammatory response]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050803 [regulation of synapse structure or activity]
GO:0050808 [synapse organization]
GO:0050890 [cognition]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051402 [neuron apoptotic process]
GO:0051425 [PTB domain binding]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070555 [response to interleukin-1]
GO:0090647 [modulation of age-related behavioral decline]
GO:0098815 [modulation of excitatory postsynaptic potential]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:1900272 [negative regulation of long-term synaptic potentiation]
GO:1900273 [positive regulation of long-term synaptic potentiation]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1904646 [cellular response to amyloid-beta]
GO:1905606 [regulation of presynapse assembly]
GO:1905908 [positive regulation of amyloid fibril formation]
GO:1990000 [amyloid fibril formation]
GO:1990535 [neuron projection maintenance]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000406 [positive regulation of T cell migration]
Show all
695 aa
78.7 kDa
Yes 1
APP-203
ENSP00000346129
ENST00000354192
P05067 [Direct mapping]
Amyloid-beta precursor protein N-APP Soluble APP-alpha Soluble APP-beta C99 Amyloid-beta protein 42 Amyloid-beta protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragment 50 C31
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Predicted secreted proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001774 [microglial cell activation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002265 [astrocyte activation involved in immune response]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005796 [Golgi lumen]
GO:0005798 [Golgi-associated vesicle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006378 [mRNA polyadenylation]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006878 [cellular copper ion homeostasis]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0007155 [cell adhesion]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007399 [nervous system development]
GO:0007409 [axonogenesis]
GO:0007611 [learning or memory]
GO:0007612 [learning]
GO:0007617 [mating behavior]
GO:0007626 [locomotory behavior]
GO:0008088 [axo-dendritic transport]
GO:0008201 [heparin binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008344 [adult locomotory behavior]
GO:0008542 [visual learning]
GO:0009986 [cell surface]
GO:0009987 [cellular process]
GO:0010466 [negative regulation of peptidase activity]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010952 [positive regulation of peptidase activity]
GO:0014005 [microglia development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016199 [axon midline choice point recognition]
GO:0016322 [neuron remodeling]
GO:0016358 [dendrite development]
GO:0019899 [enzyme binding]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0030198 [extracellular matrix organization]
GO:0030414 [peptidase inhibitor activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031093 [platelet alpha granule lumen]
GO:0031175 [neuron projection development]
GO:0031410 [cytoplasmic vesicle]
GO:0031904 [endosome lumen]
GO:0032092 [positive regulation of protein binding]
GO:0032588 [trans-Golgi network membrane]
GO:0032722 [positive regulation of chemokine production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043204 [perikaryon]
GO:0043235 [receptor complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045821 [positive regulation of glycolytic process]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0046914 [transition metal ion binding]
GO:0048143 [astrocyte activation]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048669 [collateral sprouting in absence of injury]
GO:0050729 [positive regulation of inflammatory response]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050803 [regulation of synapse structure or activity]
GO:0050808 [synapse organization]
GO:0050890 [cognition]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051402 [neuron apoptotic process]
GO:0051425 [PTB domain binding]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070555 [response to interleukin-1]
GO:0090647 [modulation of age-related behavioral decline]
GO:0098815 [modulation of excitatory postsynaptic potential]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:1900272 [negative regulation of long-term synaptic potentiation]
GO:1900273 [positive regulation of long-term synaptic potentiation]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1904646 [cellular response to amyloid-beta]
GO:1905606 [regulation of presynapse assembly]
GO:1905908 [positive regulation of amyloid fibril formation]
GO:1990000 [amyloid fibril formation]
GO:1990535 [neuron projection maintenance]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000406 [positive regulation of T cell migration]
Show all
639 aa
72.6 kDa
Yes 1
APP-204
ENSP00000350578
ENST00000357903
P05067 [Direct mapping]
Amyloid-beta precursor protein N-APP Soluble APP-alpha Soluble APP-beta C99 Amyloid-beta protein 42 Amyloid-beta protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragment 50 C31
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Predicted secreted proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001774 [microglial cell activation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002265 [astrocyte activation involved in immune response]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005796 [Golgi lumen]
GO:0005798 [Golgi-associated vesicle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006378 [mRNA polyadenylation]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006878 [cellular copper ion homeostasis]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0007155 [cell adhesion]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007399 [nervous system development]
GO:0007409 [axonogenesis]
GO:0007611 [learning or memory]
GO:0007612 [learning]
GO:0007617 [mating behavior]
GO:0007626 [locomotory behavior]
GO:0008088 [axo-dendritic transport]
GO:0008201 [heparin binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008344 [adult locomotory behavior]
GO:0008542 [visual learning]
GO:0009986 [cell surface]
GO:0009987 [cellular process]
GO:0010466 [negative regulation of peptidase activity]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010952 [positive regulation of peptidase activity]
GO:0014005 [microglia development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016199 [axon midline choice point recognition]
GO:0016322 [neuron remodeling]
GO:0016358 [dendrite development]
GO:0019899 [enzyme binding]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0030198 [extracellular matrix organization]
GO:0030414 [peptidase inhibitor activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031093 [platelet alpha granule lumen]
GO:0031175 [neuron projection development]
GO:0031410 [cytoplasmic vesicle]
GO:0031904 [endosome lumen]
GO:0032092 [positive regulation of protein binding]
GO:0032588 [trans-Golgi network membrane]
GO:0032722 [positive regulation of chemokine production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043204 [perikaryon]
GO:0043235 [receptor complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045821 [positive regulation of glycolytic process]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0046914 [transition metal ion binding]
GO:0048143 [astrocyte activation]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048669 [collateral sprouting in absence of injury]
GO:0050729 [positive regulation of inflammatory response]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050803 [regulation of synapse structure or activity]
GO:0050808 [synapse organization]
GO:0050890 [cognition]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051402 [neuron apoptotic process]
GO:0051425 [PTB domain binding]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070555 [response to interleukin-1]
GO:0090647 [modulation of age-related behavioral decline]
GO:0098815 [modulation of excitatory postsynaptic potential]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:1900272 [negative regulation of long-term synaptic potentiation]
GO:1900273 [positive regulation of long-term synaptic potentiation]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1904646 [cellular response to amyloid-beta]
GO:1905606 [regulation of presynapse assembly]
GO:1905908 [positive regulation of amyloid fibril formation]
GO:1990000 [amyloid fibril formation]
GO:1990535 [neuron projection maintenance]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000406 [positive regulation of T cell migration]
Show all
751 aa
84.8 kDa
Yes 1
APP-205
ENSP00000351796
ENST00000358918
P05067 [Direct mapping]
Amyloid-beta precursor protein N-APP Soluble APP-alpha Soluble APP-beta C99 Amyloid-beta protein 42 Amyloid-beta protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragment 50 C31
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Predicted secreted proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001774 [microglial cell activation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002265 [astrocyte activation involved in immune response]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005796 [Golgi lumen]
GO:0005798 [Golgi-associated vesicle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006378 [mRNA polyadenylation]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006878 [cellular copper ion homeostasis]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0007155 [cell adhesion]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007399 [nervous system development]
GO:0007409 [axonogenesis]
GO:0007611 [learning or memory]
GO:0007612 [learning]
GO:0007617 [mating behavior]
GO:0007626 [locomotory behavior]
GO:0008088 [axo-dendritic transport]
GO:0008201 [heparin binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008344 [adult locomotory behavior]
GO:0008542 [visual learning]
GO:0009986 [cell surface]
GO:0009987 [cellular process]
GO:0010466 [negative regulation of peptidase activity]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010952 [positive regulation of peptidase activity]
GO:0014005 [microglia development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016199 [axon midline choice point recognition]
GO:0016322 [neuron remodeling]
GO:0016358 [dendrite development]
GO:0019899 [enzyme binding]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0030198 [extracellular matrix organization]
GO:0030414 [peptidase inhibitor activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031093 [platelet alpha granule lumen]
GO:0031175 [neuron projection development]
GO:0031410 [cytoplasmic vesicle]
GO:0031904 [endosome lumen]
GO:0032092 [positive regulation of protein binding]
GO:0032588 [trans-Golgi network membrane]
GO:0032722 [positive regulation of chemokine production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043204 [perikaryon]
GO:0043235 [receptor complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045821 [positive regulation of glycolytic process]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0046914 [transition metal ion binding]
GO:0048143 [astrocyte activation]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048669 [collateral sprouting in absence of injury]
GO:0050729 [positive regulation of inflammatory response]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050803 [regulation of synapse structure or activity]
GO:0050808 [synapse organization]
GO:0050890 [cognition]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051402 [neuron apoptotic process]
GO:0051425 [PTB domain binding]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070555 [response to interleukin-1]
GO:0090647 [modulation of age-related behavioral decline]
GO:0098815 [modulation of excitatory postsynaptic potential]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:1900272 [negative regulation of long-term synaptic potentiation]
GO:1900273 [positive regulation of long-term synaptic potentiation]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1904646 [cellular response to amyloid-beta]
GO:1905606 [regulation of presynapse assembly]
GO:1905908 [positive regulation of amyloid fibril formation]
GO:1990000 [amyloid fibril formation]
GO:1990535 [neuron projection maintenance]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000406 [positive regulation of T cell migration]
Show all
752 aa
85 kDa
Yes 1
APP-206
ENSP00000352760
ENST00000359726
A0A0A0MRG2 [Direct mapping]
ABPP
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Predicted secreted proteins
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006897 [endocytosis]
GO:0007399 [nervous system development]
GO:0008201 [heparin binding]
GO:0009986 [cell surface]
GO:0010466 [negative regulation of peptidase activity]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030414 [peptidase inhibitor activity]
GO:0030426 [growth cone]
GO:0031410 [cytoplasmic vesicle]
GO:0043204 [perikaryon]
GO:0046872 [metal ion binding]
GO:0046914 [transition metal ion binding]
Show all
660 aa
75.1 kDa
No 1
APP-207
ENSP00000406539
ENST00000415997
H7C2L2 [Direct mapping]
ABPP
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005905 [clathrin-coated pit]
GO:0007399 [nervous system development]
GO:0008201 [heparin binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030426 [growth cone]
GO:0031410 [cytoplasmic vesicle]
GO:0043204 [perikaryon]
Show all
181 aa
20.3 kDa
No 0
APP-208
ENSP00000398879
ENST00000439274
E9PG40 [Direct mapping]
ABPP
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Predicted secreted proteins
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006897 [endocytosis]
GO:0007219 [Notch signaling pathway]
GO:0007399 [nervous system development]
GO:0008201 [heparin binding]
GO:0009986 [cell surface]
GO:0010466 [negative regulation of peptidase activity]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030414 [peptidase inhibitor activity]
GO:0030426 [growth cone]
GO:0031410 [cytoplasmic vesicle]
GO:0043204 [perikaryon]
GO:0046872 [metal ion binding]
GO:0046914 [transition metal ion binding]
Show all
714 aa
80.8 kDa
Yes 1
APP-209
ENSP00000387483
ENST00000440126
P05067 [Direct mapping]
Amyloid-beta precursor protein N-APP Soluble APP-alpha Soluble APP-beta C99 Amyloid-beta protein 42 Amyloid-beta protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragment 50 C31
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Predicted secreted proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001774 [microglial cell activation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002265 [astrocyte activation involved in immune response]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005796 [Golgi lumen]
GO:0005798 [Golgi-associated vesicle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006378 [mRNA polyadenylation]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006878 [cellular copper ion homeostasis]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0007155 [cell adhesion]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007399 [nervous system development]
GO:0007409 [axonogenesis]
GO:0007611 [learning or memory]
GO:0007612 [learning]
GO:0007617 [mating behavior]
GO:0007626 [locomotory behavior]
GO:0008088 [axo-dendritic transport]
GO:0008201 [heparin binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008344 [adult locomotory behavior]
GO:0008542 [visual learning]
GO:0009986 [cell surface]
GO:0009987 [cellular process]
GO:0010466 [negative regulation of peptidase activity]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010952 [positive regulation of peptidase activity]
GO:0014005 [microglia development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016199 [axon midline choice point recognition]
GO:0016322 [neuron remodeling]
GO:0016358 [dendrite development]
GO:0019899 [enzyme binding]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0030198 [extracellular matrix organization]
GO:0030414 [peptidase inhibitor activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031093 [platelet alpha granule lumen]
GO:0031175 [neuron projection development]
GO:0031410 [cytoplasmic vesicle]
GO:0031904 [endosome lumen]
GO:0032092 [positive regulation of protein binding]
GO:0032588 [trans-Golgi network membrane]
GO:0032722 [positive regulation of chemokine production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043204 [perikaryon]
GO:0043235 [receptor complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045821 [positive regulation of glycolytic process]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0046914 [transition metal ion binding]
GO:0048143 [astrocyte activation]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048669 [collateral sprouting in absence of injury]
GO:0050729 [positive regulation of inflammatory response]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050803 [regulation of synapse structure or activity]
GO:0050808 [synapse organization]
GO:0050890 [cognition]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051402 [neuron apoptotic process]
GO:0051425 [PTB domain binding]
GO:0055037 [recycling endosome]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070555 [response to interleukin-1]
GO:0090647 [modulation of age-related behavioral decline]
GO:0098815 [modulation of excitatory postsynaptic potential]
GO:0150003 [regulation of spontaneous synaptic transmission]
GO:1900272 [negative regulation of long-term synaptic potentiation]
GO:1900273 [positive regulation of long-term synaptic potentiation]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1904646 [cellular response to amyloid-beta]
GO:1905606 [regulation of presynapse assembly]
GO:1905908 [positive regulation of amyloid fibril formation]
GO:1990000 [amyloid fibril formation]
GO:1990535 [neuron projection maintenance]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000406 [positive regulation of T cell migration]
Show all
746 aa
84.5 kDa
No 1
APP-210
ENSP00000396923
ENST00000448850
H7C0V9 [Direct mapping]
ABPP
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Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0006897 [endocytosis]
GO:0007399 [nervous system development]
GO:0008201 [heparin binding]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030426 [growth cone]
GO:0031410 [cytoplasmic vesicle]
GO:0043204 [perikaryon]
GO:0046872 [metal ion binding]
GO:0046914 [transition metal ion binding]
Show all
485 aa
55 kDa
No 0

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