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AKT1
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  • AKT1
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

AKT1
Synonyms AKT, PKB, PRKBA, RAC, RAC-alpha
Gene descriptioni

Full gene name according to HGNC.

AKT serine/threonine kinase 1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Disease related genes
Enzymes
Human disease related genes
Potential drug targets
RAS pathway related proteins
Transporters
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 14
Cytoband q32.33
Chromosome location (bp) 104769349 - 104795751
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

9
Ensembl ENSG00000142208 (version 103.38)
Entrez gene 207
HGNC HGNC:391
UniProt P31749 (UniProt - Evidence at protein level)
neXtProt NX_P31749
Antibodypedia AKT1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 4      # Population variants: 184

Antigens:

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On

Variants:

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Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
AKT1-201
AKT1-202
AKT1-203
AKT1-207
AKT1-208
AKT1-211
AKT1-213
AKT1-214
AKT1-219


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
AKT1-201
ENSP00000270202
ENST00000349310
P31749 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
B0LPE5 [Target identity:100%; Query identity:100%]
RAC-PK-alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Transporters
   Accessory Factors Involved in Transport
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Human disease related genes
   Cancers
   Cancers of eye, brain, and central nervous system
   Congenital malformations
   Congenital malformations of skin
   Other congenital malformations
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003376 [sphingosine-1-phosphate receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006606 [protein import into nucleus]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007275 [multicellular organism development]
GO:0007399 [nervous system development]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008643 [carbohydrate transport]
GO:0009408 [response to heat]
GO:0010507 [negative regulation of autophagy]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010748 [negative regulation of long-chain fatty acid import across plasma membrane]
GO:0010761 [fibroblast migration]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010918 [positive regulation of mitochondrial membrane potential]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010975 [regulation of neuron projection development]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016242 [negative regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031018 [endocrine pancreas development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031929 [TOR signaling]
GO:0031982 [vesicle]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032869 [cellular response to insulin stimulus]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034405 [response to fluid shear stress]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035556 [intracellular signal transduction]
GO:0035655 [interleukin-18-mediated signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043276 [anoikis]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0043488 [regulation of mRNA stability]
GO:0043491 [protein kinase B signaling]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0045861 [negative regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046326 [positive regulation of glucose import]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060079 [excitatory postsynaptic potential]
GO:0060416 [response to growth hormone]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0070141 [response to UV-A]
GO:0071276 [cellular response to cadmium ion]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071889 [14-3-3 protein binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0098794 [postsynapse]
GO:0100002 [negative regulation of protein kinase activity by protein phosphorylation]
GO:0106310 []
GO:0106311 []
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901215 [negative regulation of neuron death]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903038 [negative regulation of leukocyte cell-cell adhesion]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903721 [positive regulation of I-kappaB phosphorylation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:2000402 [negative regulation of lymphocyte migration]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
480 aa
55.7 kDa
No 0
AKT1-202
ENSP00000385326
ENST00000402615
P31749 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
B0LPE5 [Target identity:100%; Query identity:100%]
RAC-PK-alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Transporters
   Accessory Factors Involved in Transport
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Human disease related genes
   Cancers
   Cancers of eye, brain, and central nervous system
   Congenital malformations
   Congenital malformations of skin
   Other congenital malformations
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003376 [sphingosine-1-phosphate receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006606 [protein import into nucleus]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007275 [multicellular organism development]
GO:0007399 [nervous system development]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008643 [carbohydrate transport]
GO:0009408 [response to heat]
GO:0010507 [negative regulation of autophagy]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010748 [negative regulation of long-chain fatty acid import across plasma membrane]
GO:0010761 [fibroblast migration]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010918 [positive regulation of mitochondrial membrane potential]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010975 [regulation of neuron projection development]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016242 [negative regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031018 [endocrine pancreas development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031929 [TOR signaling]
GO:0031982 [vesicle]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032869 [cellular response to insulin stimulus]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034405 [response to fluid shear stress]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035556 [intracellular signal transduction]
GO:0035655 [interleukin-18-mediated signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043276 [anoikis]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0043488 [regulation of mRNA stability]
GO:0043491 [protein kinase B signaling]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0045861 [negative regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046326 [positive regulation of glucose import]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060079 [excitatory postsynaptic potential]
GO:0060416 [response to growth hormone]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0070141 [response to UV-A]
GO:0071276 [cellular response to cadmium ion]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071889 [14-3-3 protein binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0098794 [postsynapse]
GO:0100002 [negative regulation of protein kinase activity by protein phosphorylation]
GO:0106310 []
GO:0106311 []
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901215 [negative regulation of neuron death]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903038 [negative regulation of leukocyte cell-cell adhesion]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903721 [positive regulation of I-kappaB phosphorylation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:2000402 [negative regulation of lymphocyte migration]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
480 aa
55.7 kDa
No 0
AKT1-203
ENSP00000384293
ENST00000407796
P31749 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
B0LPE5 [Target identity:100%; Query identity:100%]
RAC-PK-alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Transporters
   Accessory Factors Involved in Transport
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Human disease related genes
   Cancers
   Cancers of eye, brain, and central nervous system
   Congenital malformations
   Congenital malformations of skin
   Other congenital malformations
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003376 [sphingosine-1-phosphate receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006606 [protein import into nucleus]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007275 [multicellular organism development]
GO:0007399 [nervous system development]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008643 [carbohydrate transport]
GO:0009408 [response to heat]
GO:0010507 [negative regulation of autophagy]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010748 [negative regulation of long-chain fatty acid import across plasma membrane]
GO:0010761 [fibroblast migration]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010918 [positive regulation of mitochondrial membrane potential]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010975 [regulation of neuron projection development]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016242 [negative regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031018 [endocrine pancreas development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031929 [TOR signaling]
GO:0031982 [vesicle]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032869 [cellular response to insulin stimulus]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034405 [response to fluid shear stress]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035556 [intracellular signal transduction]
GO:0035655 [interleukin-18-mediated signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043276 [anoikis]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0043488 [regulation of mRNA stability]
GO:0043491 [protein kinase B signaling]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0045861 [negative regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046326 [positive regulation of glucose import]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060079 [excitatory postsynaptic potential]
GO:0060416 [response to growth hormone]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0070141 [response to UV-A]
GO:0071276 [cellular response to cadmium ion]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071889 [14-3-3 protein binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0098794 [postsynapse]
GO:0100002 [negative regulation of protein kinase activity by protein phosphorylation]
GO:0106310 []
GO:0106311 []
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901215 [negative regulation of neuron death]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903038 [negative regulation of leukocyte cell-cell adhesion]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903721 [positive regulation of I-kappaB phosphorylation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:2000402 [negative regulation of lymphocyte migration]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
480 aa
55.7 kDa
No 0
AKT1-207
ENSP00000450681
ENST00000554192
G3V2I6 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of eye, brain, and central nervous system
   Congenital malformations
   Congenital malformations of skin
   Other congenital malformations
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0043491 [protein kinase B signaling]
Show all
184 aa
20.9 kDa
No 0
AKT1-208
ENSP00000451828
ENST00000554581
P31749 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
B0LPE5 [Target identity:100%; Query identity:100%]
RAC-PK-alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Transporters
   Accessory Factors Involved in Transport
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Human disease related genes
   Cancers
   Cancers of eye, brain, and central nervous system
   Congenital malformations
   Congenital malformations of skin
   Other congenital malformations
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001649 [osteoblast differentiation]
GO:0001893 [maternal placenta development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003376 [sphingosine-1-phosphate receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006412 [translation]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006606 [protein import into nucleus]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007275 [multicellular organism development]
GO:0007281 [germ cell development]
GO:0007399 [nervous system development]
GO:0007568 [aging]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008637 [apoptotic mitochondrial changes]
GO:0008643 [carbohydrate transport]
GO:0009408 [response to heat]
GO:0009725 [response to hormone]
GO:0010033 [response to organic substance]
GO:0010467 [gene expression]
GO:0010507 [negative regulation of autophagy]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010748 [negative regulation of long-chain fatty acid import across plasma membrane]
GO:0010761 [fibroblast migration]
GO:0010763 [positive regulation of fibroblast migration]
GO:0010765 [positive regulation of sodium ion transport]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010918 [positive regulation of mitochondrial membrane potential]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010975 [regulation of neuron projection development]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016242 [negative regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016567 [protein ubiquitination]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021510 [spinal cord development]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030154 [cell differentiation]
GO:0030163 [protein catabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031018 [endocrine pancreas development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031641 [regulation of myelination]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0031929 [TOR signaling]
GO:0031982 [vesicle]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032091 [negative regulation of protein binding]
GO:0032094 [response to food]
GO:0032148 [activation of protein kinase B activity]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032287 [peripheral nervous system myelin maintenance]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032794 [GTPase activating protein binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0032880 [regulation of protein localization]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034405 [response to fluid shear stress]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035556 [intracellular signal transduction]
GO:0035655 [interleukin-18-mediated signaling pathway]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036064 [ciliary basal body]
GO:0036294 [cellular response to decreased oxygen levels]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0042593 [glucose homeostasis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043276 [anoikis]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0043488 [regulation of mRNA stability]
GO:0043491 [protein kinase B signaling]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0045792 [negative regulation of cell size]
GO:0045861 [negative regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046326 [positive regulation of glucose import]
GO:0046329 [negative regulation of JNK cascade]
GO:0046622 [positive regulation of organ growth]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051146 [striated muscle cell differentiation]
GO:0051721 [protein phosphatase 2A binding]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060079 [excitatory postsynaptic potential]
GO:0060416 [response to growth hormone]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0060709 [glycogen cell differentiation involved in embryonic placenta development]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0070141 [response to UV-A]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071276 [cellular response to cadmium ion]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071456 [cellular response to hypoxia]
GO:0071889 [14-3-3 protein binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus]
GO:0097194 [execution phase of apoptosis]
GO:0098794 [postsynapse]
GO:0100002 [negative regulation of protein kinase activity by protein phosphorylation]
GO:0106310 []
GO:0106311 []
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901215 [negative regulation of neuron death]
GO:1901653 [cellular response to peptide]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903038 [negative regulation of leukocyte cell-cell adhesion]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903721 [positive regulation of I-kappaB phosphorylation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:2000010 [positive regulation of protein localization to cell surface]
GO:2000402 [negative regulation of lymphocyte migration]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
480 aa
55.7 kDa
No 0
AKT1-211
ENSP00000451166
ENST00000554848
P31749 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
B0LPE5 [Target identity:100%; Query identity:100%]
RAC-PK-alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Transporters
   Accessory Factors Involved in Transport
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Human disease related genes
   Cancers
   Cancers of eye, brain, and central nervous system
   Congenital malformations
   Congenital malformations of skin
   Other congenital malformations
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003376 [sphingosine-1-phosphate receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006606 [protein import into nucleus]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007275 [multicellular organism development]
GO:0007399 [nervous system development]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008643 [carbohydrate transport]
GO:0009408 [response to heat]
GO:0010507 [negative regulation of autophagy]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010748 [negative regulation of long-chain fatty acid import across plasma membrane]
GO:0010761 [fibroblast migration]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010918 [positive regulation of mitochondrial membrane potential]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010975 [regulation of neuron projection development]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016242 [negative regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031018 [endocrine pancreas development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031929 [TOR signaling]
GO:0031982 [vesicle]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032869 [cellular response to insulin stimulus]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034405 [response to fluid shear stress]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035556 [intracellular signal transduction]
GO:0035655 [interleukin-18-mediated signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043276 [anoikis]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0043488 [regulation of mRNA stability]
GO:0043491 [protein kinase B signaling]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0045861 [negative regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046326 [positive regulation of glucose import]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060079 [excitatory postsynaptic potential]
GO:0060416 [response to growth hormone]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0070141 [response to UV-A]
GO:0071276 [cellular response to cadmium ion]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071889 [14-3-3 protein binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0098794 [postsynapse]
GO:0100002 [negative regulation of protein kinase activity by protein phosphorylation]
GO:0106310 []
GO:0106311 []
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901215 [negative regulation of neuron death]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903038 [negative regulation of leukocyte cell-cell adhesion]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903721 [positive regulation of I-kappaB phosphorylation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:2000402 [negative regulation of lymphocyte migration]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
480 aa
55.7 kDa
No 0
AKT1-213
ENSP00000451470
ENST00000555458
G3V3X1 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of eye, brain, and central nervous system
   Congenital malformations
   Congenital malformations of skin
   Other congenital malformations
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0008643 [carbohydrate transport]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0043491 [protein kinase B signaling]
Show all
170 aa
19.3 kDa
No 0
AKT1-214
ENSP00000450688
ENST00000555528
P31749 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
B0LPE5 [Target identity:100%; Query identity:100%]
RAC-PK-alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Transporters
   Accessory Factors Involved in Transport
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Human disease related genes
   Cancers
   Cancers of eye, brain, and central nervous system
   Congenital malformations
   Congenital malformations of skin
   Other congenital malformations
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003376 [sphingosine-1-phosphate receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006606 [protein import into nucleus]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007275 [multicellular organism development]
GO:0007399 [nervous system development]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008643 [carbohydrate transport]
GO:0009408 [response to heat]
GO:0010507 [negative regulation of autophagy]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010748 [negative regulation of long-chain fatty acid import across plasma membrane]
GO:0010761 [fibroblast migration]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010918 [positive regulation of mitochondrial membrane potential]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010975 [regulation of neuron projection development]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016242 [negative regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031018 [endocrine pancreas development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031929 [TOR signaling]
GO:0031982 [vesicle]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032869 [cellular response to insulin stimulus]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034405 [response to fluid shear stress]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035556 [intracellular signal transduction]
GO:0035655 [interleukin-18-mediated signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043276 [anoikis]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0043488 [regulation of mRNA stability]
GO:0043491 [protein kinase B signaling]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0045861 [negative regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046326 [positive regulation of glucose import]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060079 [excitatory postsynaptic potential]
GO:0060416 [response to growth hormone]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0070141 [response to UV-A]
GO:0071276 [cellular response to cadmium ion]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071889 [14-3-3 protein binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0098794 [postsynapse]
GO:0100002 [negative regulation of protein kinase activity by protein phosphorylation]
GO:0106310 []
GO:0106311 []
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901215 [negative regulation of neuron death]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903038 [negative regulation of leukocyte cell-cell adhesion]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903721 [positive regulation of I-kappaB phosphorylation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:2000402 [negative regulation of lymphocyte migration]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
480 aa
55.7 kDa
No 0
AKT1-219
ENSP00000497822
ENST00000649815
P31749 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
B0LPE5 [Target identity:100%; Query identity:100%]
RAC-PK-alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Transporters
   Accessory Factors Involved in Transport
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Human disease related genes
   Cancers
   Cancers of eye, brain, and central nervous system
   Congenital malformations
   Congenital malformations of skin
   Other congenital malformations
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003376 [sphingosine-1-phosphate receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006606 [protein import into nucleus]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007275 [multicellular organism development]
GO:0007399 [nervous system development]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008643 [carbohydrate transport]
GO:0009408 [response to heat]
GO:0010507 [negative regulation of autophagy]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010748 [negative regulation of long-chain fatty acid import across plasma membrane]
GO:0010761 [fibroblast migration]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010918 [positive regulation of mitochondrial membrane potential]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010975 [regulation of neuron projection development]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016242 [negative regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031018 [endocrine pancreas development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031929 [TOR signaling]
GO:0031982 [vesicle]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032869 [cellular response to insulin stimulus]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034405 [response to fluid shear stress]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035556 [intracellular signal transduction]
GO:0035655 [interleukin-18-mediated signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043276 [anoikis]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0043488 [regulation of mRNA stability]
GO:0043491 [protein kinase B signaling]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0045861 [negative regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046326 [positive regulation of glucose import]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060079 [excitatory postsynaptic potential]
GO:0060416 [response to growth hormone]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0070141 [response to UV-A]
GO:0071276 [cellular response to cadmium ion]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071889 [14-3-3 protein binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0098794 [postsynapse]
GO:0100002 [negative regulation of protein kinase activity by protein phosphorylation]
GO:0106310 []
GO:0106311 []
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901215 [negative regulation of neuron death]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903038 [negative regulation of leukocyte cell-cell adhesion]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903721 [positive regulation of I-kappaB phosphorylation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:2000402 [negative regulation of lymphocyte migration]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
480 aa
55.7 kDa
No 0

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