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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:44.4 nTPM
HPA:44.4 nTPM
GTEx:75.8 nTPM
FANTOM5:267.5 Scaled Tags Per Million
Pig:114.0 nTPM
Mouse:284.3 nTPM
Allen mouse:5.7 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 44.4
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 39.6
2411 Female, age 72, unknown 65.4
1870 Female, age 42, unknown 61.3
1827 Male, age 72, unknown 48.0
2219 Male, age 76, both hemispheres 44.8
1833 Male, age 53, unknown 41.5
1830 Male, age 51, unknown 40.2
2828 Female, age 72, unknown 26.4
2666 Male, age 74, left hemisphere 26.0
2019 Male, age 18, unknown 23.6
2586 Male, age 75, left hemisphere 18.5
Dorsal raphe nucleus
nTPM: 39.2
2750 Male, age 76, both hemispheres 50.0
2298 Female, age 72, unknown 48.5
2047 Male, age 72, unknown 35.3
1828 Male, age 53, unknown 33.9
2016 Female, age 72, unknown 28.3
Inferior colliculus
nTPM: 44.0
2097 Female, age 72, unknown 58.4
1848 Female, age 42, unknown 48.3
2849 Male, age 72, unknown 43.9
1890 Male, age 53, unknown 25.4
Median raphe nucleus
nTPM: 42.6
2220 Male, age 76, midline 42.6
Pedunculopontine tegmental nucleus
nTPM: 44.4
2334 Male, age 80, both hemispheres 55.6
1921 Female, age 85, both hemispheres 50.9
2338 Male, age 61, both hemispheres 26.6
Periaquaductal grey, anterior
nTPM: 37.1
1947 Male, age 18, unknown 44.9
2502 Female, age 75, unknown 37.9
1795 Male, age 51, unknown 28.5
Periaquaductal grey, dorsal
nTPM: 36.5
1840 Male, age 53, unknown 52.7
2464 Female, age 72, unknown 41.1
1831 Male, age 72, unknown 30.9
2850 Male, age 76, both hemispheres 21.2
Periaquaductal grey, lateral
nTPM: 29.8
2053 Male, age 18, unknown 46.1
2272 Male, age 74, both hemispheres 26.2
2140 Male, age 76, both hemispheres 17.1
Pretectal area
nTPM: 40.5
2825 Male, age 18, unknown 53.9
2224 Female, age 72, unknown 52.5
1816 Male, age 51, unknown 47.3
2007 Male, age 72, unknown 45.8
1815 Male, age 53, unknown 42.0
1944 Female, age 72, unknown 41.4
1817 Female, age 42, unknown 36.2
2316 Male, age 76, right hemisphere 35.5
2407 Male, age 75, both hemispheres 30.5
2273 Male, age 74, both hemispheres 30.3
2667 Female, age 75, unknown 29.6
Red nucleus
nTPM: 35.9
1821 Female, age 72, unknown 52.8
1954 Female, age 42, unknown 46.3
2503 Female, age 72, unknown 42.3
2725 Female, age 75, unknown 41.7
1865 Male, age 51, unknown 40.2
1904 Male, age 53, unknown 34.5
2769 Male, age 72, unknown 32.8
2227 Male, age 72, unknown 32.0
2588 Male, age 74, left hemisphere 31.9
2823 Male, age 76, right hemisphere 27.0
2785 Male, age 18, unknown 26.1
2584 Male, age 75, left hemisphere 23.0
Substantia nigra
nTPM: 36.9
2241 Male, age 72, unknown 50.1
2409 Female, age 72, unknown 48.3
1889 Female, age 72, unknown 47.6
1941 Male, age 53, unknown 39.6
2583 Male, age 75, right hemisphere 38.9
1851 Male, age 51, unknown 36.2
2590 Female, age 75, unknown 32.9
1916 Female, age 42, unknown 30.0
2699 Male, age 18, unknown 24.3
2665 Male, age 74, both hemispheres 20.9
Superior colliculus
nTPM: 41.8
1895 Male, age 76, right hemisphere 56.9
2587 Male, age 74, left hemisphere 49.6
2668 Female, age 75, unknown 48.6
1839 Male, age 51, unknown 46.5
1913 Female, age 42, unknown 45.6
2261 Male, age 18, unknown 42.9
1796 Male, age 53, unknown 42.4
2087 Female, age 72, unknown 40.8
1995 Male, age 72, unknown 28.2
2664 Male, age 75, both hemispheres 16.6
Ventral tegmental area
nTPM: 40.7
2410 Female, age 72, unknown 54.7
2223 Female, age 72, unknown 50.4
2021 Male, age 53, unknown 38.9
1915 Female, age 42, unknown 36.8
2218 Male, age 76, both hemispheres 32.6
1942 Male, age 51, unknown 30.8

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 75.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 75.8
Samples: 139

Max nTPM: 155.0
Min nTPM: 29.1
Std nTPM: 24.1
Median nTPM: 70.2
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 155.0
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 146.1
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 144.6
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 134.3
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 133.0
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 132.1
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 132.1
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 125.1
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 119.4
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 117.0
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 116.9
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 112.5
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 111.0
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 107.9
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 107.7
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 107.0
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 105.2
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 103.5
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 103.4
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 101.6
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 99.2
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 98.3
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 97.5
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 97.5
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 96.9
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 96.1
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 95.3
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 92.0
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 92.0
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 91.5
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 90.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 90.6
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 90.0
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 89.6
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 89.5
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 88.8
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 88.2
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 87.9
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 87.6
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 87.1
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 85.4
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 85.4
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 84.8
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 82.9
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 82.2
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 81.4
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 80.9
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 80.3
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 78.2
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 77.7
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 77.4
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 77.2
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 77.1
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 77.0
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 76.9
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 76.9
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 76.8
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 76.5
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 75.0
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 75.0
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 72.9
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 72.8
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 72.4
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 72.2
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 71.6
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 71.4
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 70.8
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 70.6
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 70.3
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 70.2
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 69.8
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 69.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 68.6
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 68.3
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 68.3
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 68.1
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 68.0
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 67.7
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 67.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 67.5
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 67.0
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 67.0
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 66.7
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 65.9
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 65.8
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 65.8
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 65.5
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 65.4
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 64.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 64.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 64.3
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 64.3
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 63.8
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 63.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 63.2
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 62.7
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 62.7
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 62.4
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 61.8
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 61.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 61.6
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 61.5
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 61.1
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 60.6
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 60.5
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 60.4
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 59.7
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 59.6
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 59.6
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 59.1
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 58.9
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 58.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 58.6
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 56.5
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 55.6
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 54.9
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 52.8
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 52.8
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 52.5
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 51.2
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 50.6
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 50.4
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 50.3
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 49.2
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 49.0
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 48.9
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 48.5
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 48.3
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 47.3
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 46.6
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 46.4
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 44.7
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 42.7
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 42.3
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 40.1
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 39.3
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 37.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 31.9
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 29.1
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 267.5
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 267.5
FF:10158-103A5 76 years, female 267.5

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 114.0
Pig sample Sample description nTPM
Midbrain
nTPM: 114.0
Samples: 4

Max nTPM: 135.1
Min nTPM: 94.1
Sample A Female 94.1
Sample B Female 114.5
Sample C Male 112.2
Sample D Male 135.1
Periaqueductal gray
nTPM: 96.8
Samples: 3

Max nTPM: 104.9
Min nTPM: 90.8
Sample B Female 90.8
Sample C Male 104.9
Sample D Male 94.7
Substantia nigra
nTPM: 92.2
Samples: 4

Max nTPM: 121.2
Min nTPM: 66.8
Sample A Female 121.2
Sample B Female 76.0
Sample C Male 104.6
Sample D Male 66.8
Superior colliculi
nTPM: 92.9
Samples: 4

Max nTPM: 112.9
Min nTPM: 54.1
Sample A Female 112.9
Sample B Female 54.1
Sample C Male 97.7
Sample D Male 106.9

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 284.3
Mouse sample Sample description nTPM
Midbrain
nTPM: 284.3
Samples: 4

Max nTPM: 303.7
Min nTPM: 267.5
Sample A Male 267.5
Sample B Male 282.0
Sample C Female 303.7
Sample D Female 283.9

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 5.7
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 5.7
75043158 Antisense, RP_060412_05_B09, Mouse strain C57BL/6J (56 days, male) 6.7
73424011 Antisense, RP_051019_03_C04, Mouse strain C57BL/6J (56 days, male) 4.7

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