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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:315.0 nTPM
HPA:315.0 nTPM
GTEx:354.1 nTPM
FANTOM5:493.9 Scaled Tags Per Million
Pig:157.0 nTPM
Mouse:131.7 nTPM
Allen mouse:10.7 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 315.0
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 291.8
2586 Male, age 75, left hemisphere 488.6
1833 Male, age 53, unknown 309.5
1830 Male, age 51, unknown 294.9
1870 Female, age 42, unknown 288.8
2828 Female, age 72, unknown 281.8
2411 Female, age 72, unknown 276.5
2019 Male, age 18, unknown 275.9
2666 Male, age 74, left hemisphere 264.8
1827 Male, age 72, unknown 242.4
2219 Male, age 76, both hemispheres 194.9
Dorsal raphe nucleus
nTPM: 251.0
2016 Female, age 72, unknown 267.0
2750 Male, age 76, both hemispheres 262.7
1828 Male, age 53, unknown 254.1
2298 Female, age 72, unknown 252.6
2047 Male, age 72, unknown 218.6
Inferior colliculus
nTPM: 246.2
1848 Female, age 42, unknown 276.7
2849 Male, age 72, unknown 248.4
1890 Male, age 53, unknown 240.7
2097 Female, age 72, unknown 219.1
Median raphe nucleus
nTPM: 246.7
2220 Male, age 76, midline 246.7
Pedunculopontine tegmental nucleus
nTPM: 244.0
2334 Male, age 80, both hemispheres 268.3
1921 Female, age 85, both hemispheres 248.8
2338 Male, age 61, both hemispheres 215.0
Periaquaductal grey, anterior
nTPM: 271.6
2502 Female, age 75, unknown 302.3
1795 Male, age 51, unknown 260.7
1947 Male, age 18, unknown 251.7
Periaquaductal grey, dorsal
nTPM: 242.9
2850 Male, age 76, both hemispheres 292.3
2464 Female, age 72, unknown 247.6
1840 Male, age 53, unknown 216.1
1831 Male, age 72, unknown 215.8
Periaquaductal grey, lateral
nTPM: 263.5
2140 Male, age 76, both hemispheres 312.0
2272 Male, age 74, both hemispheres 245.9
2053 Male, age 18, unknown 232.5
Pretectal area
nTPM: 254.8
2316 Male, age 76, right hemisphere 277.0
1817 Female, age 42, unknown 274.4
2007 Male, age 72, unknown 274.3
1815 Male, age 53, unknown 268.2
2224 Female, age 72, unknown 256.5
2273 Male, age 74, both hemispheres 255.0
2667 Female, age 75, unknown 249.4
2825 Male, age 18, unknown 243.9
1944 Female, age 72, unknown 239.0
2407 Male, age 75, both hemispheres 238.8
1816 Male, age 51, unknown 226.7
Red nucleus
nTPM: 315.0
2227 Male, age 72, unknown 372.7
1904 Male, age 53, unknown 370.2
2769 Male, age 72, unknown 368.6
1865 Male, age 51, unknown 348.7
1954 Female, age 42, unknown 347.1
2785 Male, age 18, unknown 323.7
1821 Female, age 72, unknown 320.8
2503 Female, age 72, unknown 298.2
2588 Male, age 74, left hemisphere 280.7
2584 Male, age 75, left hemisphere 257.7
2725 Female, age 75, unknown 247.1
2823 Male, age 76, right hemisphere 245.1
Substantia nigra
nTPM: 248.4
2583 Male, age 75, right hemisphere 299.5
2699 Male, age 18, unknown 284.3
2590 Female, age 75, unknown 274.1
1851 Male, age 51, unknown 263.1
1889 Female, age 72, unknown 254.1
1916 Female, age 42, unknown 253.1
2665 Male, age 74, both hemispheres 226.4
2409 Female, age 72, unknown 225.6
2241 Male, age 72, unknown 203.7
1941 Male, age 53, unknown 200.4
Superior colliculus
nTPM: 262.4
1995 Male, age 72, unknown 310.5
1913 Female, age 42, unknown 283.0
2664 Male, age 75, both hemispheres 280.4
2261 Male, age 18, unknown 280.2
1796 Male, age 53, unknown 270.1
2668 Female, age 75, unknown 267.9
1839 Male, age 51, unknown 258.7
2087 Female, age 72, unknown 246.0
2587 Male, age 74, left hemisphere 227.4
1895 Male, age 76, right hemisphere 199.3
Ventral tegmental area
nTPM: 256.7
2223 Female, age 72, unknown 279.0
2218 Male, age 76, both hemispheres 264.0
2410 Female, age 72, unknown 263.0
2021 Male, age 53, unknown 251.4
1942 Male, age 51, unknown 241.9
1915 Female, age 42, unknown 240.5

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 354.1
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 354.1
Samples: 139

Max nTPM: 883.7
Min nTPM: 118.3
Std nTPM: 114.8
Median nTPM: 345.9
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 883.7
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 652.0
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 611.4
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 609.8
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 592.5
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 574.0
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 557.2
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 547.9
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 546.3
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 537.8
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 534.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 528.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 521.1
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 518.0
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 511.3
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 509.8
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 498.8
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 496.5
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 494.9
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 486.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 479.4
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 473.9
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 470.3
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 458.7
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 454.7
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 445.2
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 441.7
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 439.1
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 437.5
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 420.6
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 419.5
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 413.5
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 412.4
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 402.6
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 397.5
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 396.2
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 393.6
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 391.5
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 387.6
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 385.0
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 384.9
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 382.3
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 380.0
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 378.0
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 376.9
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 374.9
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 374.0
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 372.3
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 371.1
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 370.6
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 370.5
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 370.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 367.9
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 367.8
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 366.5
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 364.6
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 362.8
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 362.4
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 361.7
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 361.6
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 360.8
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 357.6
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 355.9
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 355.6
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 354.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 354.2
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 353.1
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 349.8
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 347.5
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 345.9
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 344.1
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 344.1
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 342.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 341.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 341.5
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 340.9
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 337.4
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 333.2
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 329.5
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 328.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 326.6
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 322.9
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 318.8
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 318.5
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 317.1
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 312.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 309.4
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 308.9
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 308.9
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 307.9
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 306.6
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 304.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 302.5
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 300.0
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 299.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 298.6
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 298.5
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 296.3
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 294.7
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 290.9
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 286.4
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 286.3
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 284.0
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 284.0
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 280.0
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 279.1
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 278.6
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 275.1
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 269.3
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 266.4
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 260.7
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 258.8
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 258.1
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 252.8
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 246.0
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 240.4
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 237.6
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 236.6
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 236.5
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 234.6
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 229.6
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 228.3
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 224.5
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 223.4
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 220.5
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 220.3
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 216.7
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 209.4
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 208.7
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 206.9
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 203.2
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 198.1
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 197.0
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 187.6
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 175.5
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 172.1
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 162.9
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 149.9
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 118.3
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 493.9
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 493.9
FF:10158-103A5 76 years, female 493.9

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 157.0
Pig sample Sample description nTPM
Midbrain
nTPM: 156.5
Samples: 4

Max nTPM: 215.3
Min nTPM: 92.6
Sample A Female 211.5
Sample B Female 106.5
Sample C Male 215.3
Sample D Male 92.6
Periaqueductal gray
nTPM: 91.2
Samples: 3

Max nTPM: 95.8
Min nTPM: 84.3
Sample B Female 95.8
Sample C Male 93.6
Sample D Male 84.3
Substantia nigra
nTPM: 133.2
Samples: 4

Max nTPM: 151.2
Min nTPM: 114.2
Sample A Female 151.2
Sample B Female 123.9
Sample C Male 114.2
Sample D Male 143.4
Superior colliculi
nTPM: 157.0
Samples: 4

Max nTPM: 187.5
Min nTPM: 137.4
Sample A Female 157.8
Sample B Female 137.4
Sample C Male 187.5
Sample D Male 145.3

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 131.7
Mouse sample Sample description nTPM
Midbrain
nTPM: 131.7
Samples: 4

Max nTPM: 139.3
Min nTPM: 120.7
Sample A Male 139.1
Sample B Male 120.7
Sample C Female 127.7
Sample D Female 139.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 10.7
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 10.7
70429393 Antisense, RP_050614_01_E12, Mouse strain C57BL/6J (56 days, male) 10.7

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