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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:235.8 nTPM
HPA:235.8 nTPM
GTEx:188.9 nTPM
FANTOM5:6.6 Scaled Tags Per Million
Pig:188.1 nTPM
Mouse:380.6 nTPM
Allen mouse:10.1 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 235.8
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 214.1
2666 Male, age 74, left hemisphere 240.4
2219 Male, age 76, both hemispheres 227.5
2411 Female, age 72, unknown 221.4
1827 Male, age 72, unknown 218.7
2019 Male, age 18, unknown 217.1
1870 Female, age 42, unknown 205.1
1833 Male, age 53, unknown 203.5
2828 Female, age 72, unknown 203.3
2586 Male, age 75, left hemisphere 202.4
1830 Male, age 51, unknown 201.7
Dorsal raphe nucleus
nTPM: 211.6
2298 Female, age 72, unknown 230.2
2750 Male, age 76, both hemispheres 218.8
2047 Male, age 72, unknown 215.0
1828 Male, age 53, unknown 203.2
2016 Female, age 72, unknown 190.6
Inferior colliculus
nTPM: 216.0
2097 Female, age 72, unknown 237.0
1848 Female, age 42, unknown 210.6
1890 Male, age 53, unknown 209.4
2849 Male, age 72, unknown 206.7
Median raphe nucleus
nTPM: 235.8
2220 Male, age 76, midline 235.8
Pedunculopontine tegmental nucleus
nTPM: 228.1
2334 Male, age 80, both hemispheres 234.6
1921 Female, age 85, both hemispheres 233.8
2338 Male, age 61, both hemispheres 215.9
Periaquaductal grey, anterior
nTPM: 215.0
1795 Male, age 51, unknown 218.3
1947 Male, age 18, unknown 214.8
2502 Female, age 75, unknown 211.9
Periaquaductal grey, dorsal
nTPM: 206.9
1840 Male, age 53, unknown 211.0
2850 Male, age 76, both hemispheres 207.4
1831 Male, age 72, unknown 204.8
2464 Female, age 72, unknown 204.4
Periaquaductal grey, lateral
nTPM: 200.4
2053 Male, age 18, unknown 202.8
2272 Male, age 74, both hemispheres 200.6
2140 Male, age 76, both hemispheres 197.8
Pretectal area
nTPM: 222.8
1944 Female, age 72, unknown 254.7
1817 Female, age 42, unknown 248.5
1816 Male, age 51, unknown 246.0
2007 Male, age 72, unknown 240.2
1815 Male, age 53, unknown 232.7
2667 Female, age 75, unknown 216.2
2224 Female, age 72, unknown 214.0
2825 Male, age 18, unknown 204.0
2407 Male, age 75, both hemispheres 200.0
2273 Male, age 74, both hemispheres 198.1
2316 Male, age 76, right hemisphere 196.0
Red nucleus
nTPM: 199.2
2785 Male, age 18, unknown 215.2
1821 Female, age 72, unknown 212.7
1954 Female, age 42, unknown 204.3
2584 Male, age 75, left hemisphere 203.3
2769 Male, age 72, unknown 198.0
2227 Male, age 72, unknown 197.8
1904 Male, age 53, unknown 197.2
2823 Male, age 76, right hemisphere 197.2
1865 Male, age 51, unknown 195.2
2503 Female, age 72, unknown 192.1
2725 Female, age 75, unknown 190.7
2588 Male, age 74, left hemisphere 186.7
Substantia nigra
nTPM: 225.5
1941 Male, age 53, unknown 257.4
1916 Female, age 42, unknown 252.5
1889 Female, age 72, unknown 250.4
1851 Male, age 51, unknown 235.9
2241 Male, age 72, unknown 228.2
2665 Male, age 74, both hemispheres 217.1
2409 Female, age 72, unknown 216.8
2699 Male, age 18, unknown 206.8
2583 Male, age 75, right hemisphere 196.0
2590 Female, age 75, unknown 193.6
Superior colliculus
nTPM: 220.9
2668 Female, age 75, unknown 308.1
2087 Female, age 72, unknown 235.5
1796 Male, age 53, unknown 218.4
1895 Male, age 76, right hemisphere 217.8
2261 Male, age 18, unknown 217.8
1913 Female, age 42, unknown 207.3
1839 Male, age 51, unknown 206.7
2587 Male, age 74, left hemisphere 201.3
2664 Male, age 75, both hemispheres 198.7
1995 Male, age 72, unknown 197.2
Ventral tegmental area
nTPM: 221.7
2410 Female, age 72, unknown 241.8
2218 Male, age 76, both hemispheres 237.9
1915 Female, age 42, unknown 225.6
1942 Male, age 51, unknown 211.6
2223 Female, age 72, unknown 210.6
2021 Male, age 53, unknown 202.5

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 188.9
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 188.9
Samples: 139

Max nTPM: 991.9
Min nTPM: 19.1
Std nTPM: 156.7
Median nTPM: 153.5
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 991.9
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 822.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 616.0
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 540.5
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 508.7
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 475.0
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 473.1
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 471.9
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 441.0
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 412.0
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 384.7
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 384.2
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 375.9
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 374.5
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 372.1
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 363.5
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 361.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 348.2
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 348.0
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 345.3
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 340.6
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 340.4
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 329.6
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 326.0
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 320.1
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 317.1
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 311.7
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 302.0
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 296.7
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 291.4
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 289.3
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 281.2
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 280.5
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 275.2
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 267.7
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 262.7
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 255.6
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 247.0
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 244.4
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 244.1
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 243.7
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 242.2
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 240.6
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 240.5
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 231.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 230.8
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 229.6
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 227.7
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 224.7
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 209.0
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 208.4
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 205.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 204.1
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 203.6
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 200.4
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 200.3
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 195.3
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 192.6
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 190.3
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 186.1
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 185.5
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 184.1
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 182.7
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 180.2
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 180.2
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 172.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 171.6
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 168.0
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 153.5
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 153.5
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 153.4
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 146.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 145.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 144.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 144.0
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 138.9
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 137.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 131.6
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 130.3
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 124.9
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 107.8
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 106.9
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 106.7
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 106.1
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 102.2
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 97.8
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 95.4
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 95.3
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 91.3
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 90.3
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 89.7
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 88.2
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 87.4
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 86.5
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 85.3
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 84.1
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 81.5
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 80.7
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 75.9
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 74.1
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 72.0
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 71.6
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 70.9
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 68.3
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 65.2
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 65.0
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 64.4
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 64.0
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 63.8
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 59.3
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 58.8
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 58.6
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 57.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 57.7
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 56.3
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 56.2
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 52.0
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 50.1
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 41.8
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 40.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 40.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 39.5
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 39.1
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 35.8
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 35.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 35.5
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 35.1
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 33.6
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 32.9
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 31.7
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 27.8
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 26.2
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 24.2
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 24.1
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 21.4
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 20.9
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 20.2
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 19.3
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 19.1
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 6.6
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 6.6
FF:10158-103A5 76 years, female 6.6

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 188.1
Pig sample Sample description nTPM
Midbrain
nTPM: 144.1
Samples: 4

Max nTPM: 232.0
Min nTPM: 43.4
Sample A Female 43.4
Sample B Female 113.8
Sample C Male 232.0
Sample D Male 187.3
Periaqueductal gray
nTPM: 111.6
Samples: 3

Max nTPM: 146.7
Min nTPM: 88.3
Sample B Female 88.3
Sample C Male 146.7
Sample D Male 99.9
Substantia nigra
nTPM: 136.8
Samples: 4

Max nTPM: 227.2
Min nTPM: 28.6
Sample A Female 227.2
Sample B Female 90.8
Sample C Male 200.4
Sample D Male 28.6
Superior colliculi
nTPM: 188.2
Samples: 4

Max nTPM: 252.5
Min nTPM: 128.2
Sample A Female 189.0
Sample B Female 128.2
Sample C Male 252.5
Sample D Male 182.9

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 380.6
Mouse sample Sample description nTPM
Midbrain
nTPM: 380.6
Samples: 4

Max nTPM: 388.2
Min nTPM: 372.8
Sample A Male 377.4
Sample B Male 388.2
Sample C Female 372.8
Sample D Female 384.0

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 10.1
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 10.1
75988633 Antisense, RP_060620_02_E05, Mouse strain C57BL/6J (56 days, male) 10.7
71280733 Antisense, RP_050818_01_E04, Mouse strain C57BL/6J (56 days, male) 9.5

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