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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:106.2 nTPM
HPA:106.2 nTPM
GTEx:56.8 nTPM
FANTOM5:53.5 Scaled Tags Per Million
Pig:24.2 nTPM
Mouse:51.5 nTPM
Allen mouse:0.7 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 106.2
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 86.1
2586 Male, age 75, left hemisphere 135.3
2828 Female, age 72, unknown 119.1
1827 Male, age 72, unknown 89.5
2666 Male, age 74, left hemisphere 84.1
1870 Female, age 42, unknown 77.9
1830 Male, age 51, unknown 77.0
1833 Male, age 53, unknown 75.9
2411 Female, age 72, unknown 70.5
2019 Male, age 18, unknown 69.5
2219 Male, age 76, both hemispheres 61.9
Dorsal raphe nucleus
nTPM: 91.6
1828 Male, age 53, unknown 105.4
2016 Female, age 72, unknown 103.8
2047 Male, age 72, unknown 97.0
2298 Female, age 72, unknown 80.8
2750 Male, age 76, both hemispheres 71.0
Inferior colliculus
nTPM: 106.2
1848 Female, age 42, unknown 112.0
2849 Male, age 72, unknown 107.1
1890 Male, age 53, unknown 102.9
2097 Female, age 72, unknown 102.8
Median raphe nucleus
nTPM: 59.9
2220 Male, age 76, midline 59.9
Pedunculopontine tegmental nucleus
nTPM: 59.6
1921 Female, age 85, both hemispheres 78.9
2334 Male, age 80, both hemispheres 63.2
2338 Male, age 61, both hemispheres 36.7
Periaquaductal grey, anterior
nTPM: 89.4
2502 Female, age 75, unknown 93.4
1947 Male, age 18, unknown 87.8
1795 Male, age 51, unknown 87.2
Periaquaductal grey, dorsal
nTPM: 95.5
1840 Male, age 53, unknown 107.5
2464 Female, age 72, unknown 99.2
2850 Male, age 76, both hemispheres 89.5
1831 Male, age 72, unknown 85.6
Periaquaductal grey, lateral
nTPM: 92.3
2053 Male, age 18, unknown 105.4
2140 Male, age 76, both hemispheres 104.5
2272 Male, age 74, both hemispheres 67.0
Pretectal area
nTPM: 85.3
2825 Male, age 18, unknown 104.6
2316 Male, age 76, right hemisphere 95.0
2273 Male, age 74, both hemispheres 91.5
1944 Female, age 72, unknown 88.8
2667 Female, age 75, unknown 88.2
1817 Female, age 42, unknown 88.0
1815 Male, age 53, unknown 81.2
1816 Male, age 51, unknown 79.9
2407 Male, age 75, both hemispheres 75.6
2007 Male, age 72, unknown 73.7
2224 Female, age 72, unknown 71.8
Red nucleus
nTPM: 96.7
1954 Female, age 42, unknown 121.7
2503 Female, age 72, unknown 115.5
2588 Male, age 74, left hemisphere 112.1
2769 Male, age 72, unknown 106.8
2227 Male, age 72, unknown 104.0
2725 Female, age 75, unknown 98.0
1821 Female, age 72, unknown 97.7
2823 Male, age 76, right hemisphere 96.6
1865 Male, age 51, unknown 88.2
1904 Male, age 53, unknown 85.2
2584 Male, age 75, left hemisphere 67.6
2785 Male, age 18, unknown 67.4
Substantia nigra
nTPM: 69.6
2699 Male, age 18, unknown 79.0
1889 Female, age 72, unknown 76.9
2409 Female, age 72, unknown 74.6
2583 Male, age 75, right hemisphere 73.7
1916 Female, age 42, unknown 71.6
2241 Male, age 72, unknown 66.7
1851 Male, age 51, unknown 64.9
1941 Male, age 53, unknown 64.5
2590 Female, age 75, unknown 63.3
2665 Male, age 74, both hemispheres 60.6
Superior colliculus
nTPM: 87.1
2664 Male, age 75, both hemispheres 111.3
1839 Male, age 51, unknown 98.5
1796 Male, age 53, unknown 91.1
2261 Male, age 18, unknown 90.8
2087 Female, age 72, unknown 86.8
1895 Male, age 76, right hemisphere 85.4
2668 Female, age 75, unknown 84.4
2587 Male, age 74, left hemisphere 81.4
1995 Male, age 72, unknown 80.4
1913 Female, age 42, unknown 61.2
Ventral tegmental area
nTPM: 69.9
2410 Female, age 72, unknown 82.6
1942 Male, age 51, unknown 81.7
1915 Female, age 42, unknown 72.5
2021 Male, age 53, unknown 70.5
2218 Male, age 76, both hemispheres 57.4
2223 Female, age 72, unknown 55.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 56.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 56.8
Samples: 139

Max nTPM: 145.6
Min nTPM: 12.4
Std nTPM: 27.4
Median nTPM: 52.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 145.6
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 136.5
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 128.1
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 125.4
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 124.1
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 116.1
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 115.8
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 114.5
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 108.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 103.0
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 101.9
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 94.3
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 91.3
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 90.2
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 88.5
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 88.3
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 87.8
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 87.6
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 87.5
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 87.3
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 84.4
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 82.8
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 82.6
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 81.8
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 81.8
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 81.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 77.0
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 76.9
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 76.3
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 75.8
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 75.8
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 75.4
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 74.4
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 73.5
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 72.4
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 72.1
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 70.8
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 70.7
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 70.5
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 70.4
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 69.6
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 67.9
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 67.7
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 66.7
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 66.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 66.2
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 65.5
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 65.4
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 65.1
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 63.7
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 62.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 62.1
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 61.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 61.2
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 61.1
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 58.7
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 58.6
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 58.4
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 58.3
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 57.6
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 57.1
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 56.9
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 56.5
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 55.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 55.0
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 54.8
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 54.4
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 53.6
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 52.9
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 52.9
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 52.6
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 52.4
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 52.2
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 52.2
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 52.1
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 51.8
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 50.8
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 49.7
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 49.0
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 48.4
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 48.3
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 47.6
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 47.3
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 45.1
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 45.0
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 44.8
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 44.7
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 43.8
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 42.6
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 41.7
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 40.7
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 40.6
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 40.2
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 40.2
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 38.8
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 38.8
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 38.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 38.5
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 38.4
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 38.2
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 38.0
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 36.4
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 36.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 36.1
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 36.0
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 34.9
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 34.8
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 34.5
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 34.5
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 34.4
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 34.0
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 31.4
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 31.4
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 29.8
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 29.2
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 29.1
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 28.9
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 28.2
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 28.1
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 27.4
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 26.5
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 25.8
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 25.6
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 25.6
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 25.2
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 25.0
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 24.3
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 23.8
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 23.4
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 23.1
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 22.9
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 22.7
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 21.9
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 20.4
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 19.6
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 18.3
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 16.1
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 14.4
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 12.4
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 53.5
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 53.5
FF:10158-103A5 76 years, female 53.5

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 24.2
Pig sample Sample description nTPM
Midbrain
nTPM: 24.2
Samples: 4

Max nTPM: 29.4
Min nTPM: 18.8
Sample A Female 29.4
Sample B Female 18.8
Sample C Male 23.8
Sample D Male 24.9
Periaqueductal gray
nTPM: 17.8
Samples: 3

Max nTPM: 20.1
Min nTPM: 13.7
Sample B Female 20.1
Sample C Male 19.6
Sample D Male 13.7
Substantia nigra
nTPM: 23.5
Samples: 4

Max nTPM: 31.6
Min nTPM: 17.1
Sample A Female 23.0
Sample B Female 17.1
Sample C Male 22.1
Sample D Male 31.6
Superior colliculi
nTPM: 20.7
Samples: 4

Max nTPM: 27.3
Min nTPM: 11.1
Sample A Female 27.3
Sample B Female 11.1
Sample C Male 23.0
Sample D Male 21.2

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 51.5
Mouse sample Sample description nTPM
Midbrain
nTPM: 51.5
Samples: 4

Max nTPM: 55.1
Min nTPM: 46.0
Sample A Male 54.2
Sample B Male 50.6
Sample C Female 46.0
Sample D Female 55.1

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.7
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.7
73712870 Antisense, RP_051206_02_E11, Mouse strain C57BL/6J (56 days, male) 0.7

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