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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
p11.2
Chromosome location (bp)
55019017 - 55211628
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
EGFR-201
EGFR-202
EGFR-203
EGFR-204
EGFR-205
EGFR-206
EGFR-207
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Metabolic proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0000186 [activation of MAPKK activity] GO:0001503 [ossification] GO:0001618 [virus receptor activity] GO:0001889 [liver development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001942 [hair follicle development] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0004672 [protein kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005006 [epidermal growth factor-activated receptor activity] GO:0005102 [signaling receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006412 [translation] GO:0006468 [protein phosphorylation] GO:0006970 [response to osmotic stress] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007275 [multicellular organism development] GO:0007494 [midgut development] GO:0007611 [learning or memory] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell population proliferation] GO:0009925 [basal plasma membrane] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0010750 [positive regulation of nitric oxide mediated signal transduction] GO:0010960 [magnesium ion homeostasis] GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016101 [diterpenoid metabolic process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0030054 [cell junction] GO:0030139 [endocytic vesicle] GO:0030154 [cell differentiation] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030665 [clathrin-coated vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032355 [response to estradiol] GO:0032930 [positive regulation of superoxide anion generation] GO:0032991 [protein-containing complex] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033590 [response to cobalamin] GO:0033594 [response to hydroxyisoflavone] GO:0033674 [positive regulation of kinase activity] GO:0033993 [response to lipid] GO:0034614 [cellular response to reactive oxygen species] GO:0035556 [intracellular signal transduction] GO:0035690 [cellular response to drug] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038128 [ERBB2 signaling pathway] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042060 [wound healing] GO:0042177 [negative regulation of protein catabolic process] GO:0042327 [positive regulation of phosphorylation] GO:0042698 [ovulation cycle] GO:0042743 [hydrogen peroxide metabolic process] GO:0042802 [identical protein binding] GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling] GO:0043066 [negative regulation of apoptotic process] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0043586 [tongue development] GO:0044877 [protein-containing complex binding] GO:0045121 [membrane raft] GO:0045202 [synapse] GO:0045296 [cadherin binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045739 [positive regulation of DNA repair] GO:0045740 [positive regulation of DNA replication] GO:0045746 [negative regulation of Notch signaling pathway] GO:0045780 [positive regulation of bone resorption] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045907 [positive regulation of vasoconstriction] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046328 [regulation of JNK cascade] GO:0046718 [viral entry into host cell] GO:0046777 [protein autophosphorylation] GO:0048143 [astrocyte activation] GO:0048408 [epidermal growth factor binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0048812 [neuron projection morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050729 [positive regulation of inflammatory response] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051015 [actin filament binding] GO:0051117 [ATPase binding] GO:0051205 [protein insertion into membrane] GO:0051592 [response to calcium ion] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070435 [Shc-EGFR complex] GO:0071260 [cellular response to mechanical stimulus] GO:0071276 [cellular response to cadmium ion] GO:0071363 [cellular response to growth factor stimulus] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071392 [cellular response to estradiol stimulus] GO:0071549 [cellular response to dexamethasone stimulus] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0097421 [liver regeneration] GO:0097489 [multivesicular body, internal vesicle lumen] GO:0097755 [positive regulation of blood vessel diameter] GO:0098609 [cell-cell adhesion] GO:1900020 [positive regulation of protein kinase C activity] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] GO:1901185 [negative regulation of ERBB signaling pathway] GO:1901224 [positive regulation of NIK/NF-kappaB signaling] GO:1902722 [positive regulation of prolactin secretion] GO:1903078 [positive regulation of protein localization to plasma membrane] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905208 [negative regulation of cardiocyte differentiation] GO:2000145 [regulation of cell motility]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Metabolic proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0001503 [ossification] GO:0001618 [virus receptor activity] GO:0001934 [positive regulation of protein phosphorylation] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0004672 [protein kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005006 [epidermal growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007275 [multicellular organism development] GO:0007611 [learning or memory] GO:0008284 [positive regulation of cell population proliferation] GO:0009925 [basal plasma membrane] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0010750 [positive regulation of nitric oxide mediated signal transduction] GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016323 [basolateral plasma membrane] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019903 [protein phosphatase binding] GO:0030054 [cell junction] GO:0030154 [cell differentiation] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0030665 [clathrin-coated vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032991 [protein-containing complex] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033674 [positive regulation of kinase activity] GO:0034614 [cellular response to reactive oxygen species] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038128 [ERBB2 signaling pathway] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042177 [negative regulation of protein catabolic process] GO:0042327 [positive regulation of phosphorylation] GO:0042802 [identical protein binding] GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling] GO:0043066 [negative regulation of apoptotic process] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0045121 [membrane raft] GO:0045296 [cadherin binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045739 [positive regulation of DNA repair] GO:0045740 [positive regulation of DNA replication] GO:0045746 [negative regulation of Notch signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046328 [regulation of JNK cascade] GO:0046718 [viral entry into host cell] GO:0046777 [protein autophosphorylation] GO:0048408 [epidermal growth factor binding] GO:0048471 [perinuclear region of cytoplasm] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051015 [actin filament binding] GO:0051117 [ATPase binding] GO:0051205 [protein insertion into membrane] GO:0051897 [positive regulation of protein kinase B signaling] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070435 [Shc-EGFR complex] GO:0071276 [cellular response to cadmium ion] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071392 [cellular response to estradiol stimulus] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0097489 [multivesicular body, internal vesicle lumen] GO:0098609 [cell-cell adhesion] GO:1900020 [positive regulation of protein kinase C activity] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] GO:1901185 [negative regulation of ERBB signaling pathway] GO:1901224 [positive regulation of NIK/NF-kappaB signaling] GO:1903078 [positive regulation of protein localization to plasma membrane] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905208 [negative regulation of cardiocyte differentiation] GO:2000145 [regulation of cell motility]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Metabolic proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0001503 [ossification] GO:0001618 [virus receptor activity] GO:0001934 [positive regulation of protein phosphorylation] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0004672 [protein kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005006 [epidermal growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007275 [multicellular organism development] GO:0007611 [learning or memory] GO:0008284 [positive regulation of cell population proliferation] GO:0009925 [basal plasma membrane] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0010750 [positive regulation of nitric oxide mediated signal transduction] GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016323 [basolateral plasma membrane] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019903 [protein phosphatase binding] GO:0030054 [cell junction] GO:0030154 [cell differentiation] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0030665 [clathrin-coated vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032991 [protein-containing complex] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033674 [positive regulation of kinase activity] GO:0034614 [cellular response to reactive oxygen species] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038128 [ERBB2 signaling pathway] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042177 [negative regulation of protein catabolic process] GO:0042327 [positive regulation of phosphorylation] GO:0042802 [identical protein binding] GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling] GO:0043066 [negative regulation of apoptotic process] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0045121 [membrane raft] GO:0045296 [cadherin binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045739 [positive regulation of DNA repair] GO:0045740 [positive regulation of DNA replication] GO:0045746 [negative regulation of Notch signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046328 [regulation of JNK cascade] GO:0046718 [viral entry into host cell] GO:0046777 [protein autophosphorylation] GO:0048408 [epidermal growth factor binding] GO:0048471 [perinuclear region of cytoplasm] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051015 [actin filament binding] GO:0051117 [ATPase binding] GO:0051205 [protein insertion into membrane] GO:0051897 [positive regulation of protein kinase B signaling] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070435 [Shc-EGFR complex] GO:0071276 [cellular response to cadmium ion] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071392 [cellular response to estradiol stimulus] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0097489 [multivesicular body, internal vesicle lumen] GO:0098609 [cell-cell adhesion] GO:1900020 [positive regulation of protein kinase C activity] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] GO:1901185 [negative regulation of ERBB signaling pathway] GO:1901224 [positive regulation of NIK/NF-kappaB signaling] GO:1903078 [positive regulation of protein localization to plasma membrane] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905208 [negative regulation of cardiocyte differentiation] GO:2000145 [regulation of cell motility]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Metabolic proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0001503 [ossification] GO:0001618 [virus receptor activity] GO:0001934 [positive regulation of protein phosphorylation] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0004672 [protein kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005006 [epidermal growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007275 [multicellular organism development] GO:0007611 [learning or memory] GO:0008284 [positive regulation of cell population proliferation] GO:0009925 [basal plasma membrane] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0010750 [positive regulation of nitric oxide mediated signal transduction] GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016323 [basolateral plasma membrane] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019903 [protein phosphatase binding] GO:0030054 [cell junction] GO:0030154 [cell differentiation] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0030665 [clathrin-coated vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032991 [protein-containing complex] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033674 [positive regulation of kinase activity] GO:0034614 [cellular response to reactive oxygen species] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038128 [ERBB2 signaling pathway] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042177 [negative regulation of protein catabolic process] GO:0042327 [positive regulation of phosphorylation] GO:0042802 [identical protein binding] GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling] GO:0043066 [negative regulation of apoptotic process] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0045121 [membrane raft] GO:0045296 [cadherin binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045739 [positive regulation of DNA repair] GO:0045740 [positive regulation of DNA replication] GO:0045746 [negative regulation of Notch signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046328 [regulation of JNK cascade] GO:0046718 [viral entry into host cell] GO:0046777 [protein autophosphorylation] GO:0048408 [epidermal growth factor binding] GO:0048471 [perinuclear region of cytoplasm] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051015 [actin filament binding] GO:0051117 [ATPase binding] GO:0051205 [protein insertion into membrane] GO:0051897 [positive regulation of protein kinase B signaling] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070435 [Shc-EGFR complex] GO:0071276 [cellular response to cadmium ion] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071392 [cellular response to estradiol stimulus] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0097489 [multivesicular body, internal vesicle lumen] GO:0098609 [cell-cell adhesion] GO:1900020 [positive regulation of protein kinase C activity] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] GO:1901185 [negative regulation of ERBB signaling pathway] GO:1901224 [positive regulation of NIK/NF-kappaB signaling] GO:1903078 [positive regulation of protein localization to plasma membrane] GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA] GO:1905208 [negative regulation of cardiocyte differentiation] GO:2000145 [regulation of cell motility]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Immune system diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Immune system diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of the breast and female genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Immune system diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)