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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:136.9 nTPM
HPA:136.9 nTPM
GTEx:548.2 nTPM
FANTOM5:695.2 Scaled Tags Per Million
Pig:208.7 nTPM
Mouse:477.0 nTPM
Allen mouse:17.7 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 136.9
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 118.2
2586 Male, age 75, left hemisphere 134.8
2411 Female, age 72, unknown 133.8
1870 Female, age 42, unknown 132.0
2019 Male, age 18, unknown 129.3
1830 Male, age 51, unknown 127.4
1833 Male, age 53, unknown 124.0
2666 Male, age 74, left hemisphere 103.3
1827 Male, age 72, unknown 102.2
2828 Female, age 72, unknown 101.3
2219 Male, age 76, both hemispheres 93.7
Dorsal raphe nucleus
nTPM: 104.3
2750 Male, age 76, both hemispheres 126.1
2047 Male, age 72, unknown 105.5
1828 Male, age 53, unknown 102.5
2016 Female, age 72, unknown 95.7
2298 Female, age 72, unknown 91.6
Inferior colliculus
nTPM: 104.5
1890 Male, age 53, unknown 112.9
1848 Female, age 42, unknown 105.6
2097 Female, age 72, unknown 103.7
2849 Male, age 72, unknown 95.7
Median raphe nucleus
nTPM: 109.6
2220 Male, age 76, midline 109.6
Pedunculopontine tegmental nucleus
nTPM: 108.7
2334 Male, age 80, both hemispheres 114.8
2338 Male, age 61, both hemispheres 107.6
1921 Female, age 85, both hemispheres 103.8
Periaquaductal grey, anterior
nTPM: 92.5
1947 Male, age 18, unknown 99.2
2502 Female, age 75, unknown 94.0
1795 Male, age 51, unknown 84.4
Periaquaductal grey, dorsal
nTPM: 88.5
2464 Female, age 72, unknown 97.4
1831 Male, age 72, unknown 89.9
1840 Male, age 53, unknown 84.8
2850 Male, age 76, both hemispheres 81.7
Periaquaductal grey, lateral
nTPM: 87.3
2053 Male, age 18, unknown 98.8
2272 Male, age 74, both hemispheres 84.0
2140 Male, age 76, both hemispheres 79.1
Pretectal area
nTPM: 94.9
1815 Male, age 53, unknown 107.6
1817 Female, age 42, unknown 104.3
2007 Male, age 72, unknown 101.5
2407 Male, age 75, both hemispheres 100.7
2316 Male, age 76, right hemisphere 95.0
2825 Male, age 18, unknown 94.9
2667 Female, age 75, unknown 91.8
1944 Female, age 72, unknown 89.8
2224 Female, age 72, unknown 88.3
1816 Male, age 51, unknown 87.7
2273 Male, age 74, both hemispheres 82.6
Red nucleus
nTPM: 136.9
1821 Female, age 72, unknown 156.9
2588 Male, age 74, left hemisphere 150.4
1904 Male, age 53, unknown 146.9
1865 Male, age 51, unknown 144.1
2227 Male, age 72, unknown 141.4
1954 Female, age 42, unknown 140.3
2769 Male, age 72, unknown 138.3
2503 Female, age 72, unknown 129.2
2823 Male, age 76, right hemisphere 127.9
2785 Male, age 18, unknown 124.4
2584 Male, age 75, left hemisphere 121.8
2725 Female, age 75, unknown 121.7
Substantia nigra
nTPM: 106.1
2583 Male, age 75, right hemisphere 121.8
1851 Male, age 51, unknown 113.6
1889 Female, age 72, unknown 111.2
2409 Female, age 72, unknown 108.7
2241 Male, age 72, unknown 108.0
2590 Female, age 75, unknown 104.1
1941 Male, age 53, unknown 99.7
1916 Female, age 42, unknown 98.4
2665 Male, age 74, both hemispheres 98.0
2699 Male, age 18, unknown 97.3
Superior colliculus
nTPM: 103.8
2668 Female, age 75, unknown 117.5
2587 Male, age 74, left hemisphere 114.3
1913 Female, age 42, unknown 110.8
1839 Male, age 51, unknown 107.1
1995 Male, age 72, unknown 106.6
1895 Male, age 76, right hemisphere 106.4
2664 Male, age 75, both hemispheres 103.9
1796 Male, age 53, unknown 93.4
2261 Male, age 18, unknown 89.2
2087 Female, age 72, unknown 89.0
Ventral tegmental area
nTPM: 113.1
2223 Female, age 72, unknown 147.0
2410 Female, age 72, unknown 116.7
2218 Male, age 76, both hemispheres 107.3
1942 Male, age 51, unknown 104.9
1915 Female, age 42, unknown 103.6
2021 Male, age 53, unknown 98.8

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 548.2
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 548.2
Samples: 139

Max nTPM: 1150.5
Min nTPM: 217.6
Std nTPM: 173.7
Median nTPM: 513.3
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 1150.5
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 1123.7
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 1032.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 949.5
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 941.7
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 922.0
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 891.3
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 888.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 883.9
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 875.3
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 843.0
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 807.8
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 804.4
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 803.7
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 796.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 762.5
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 754.4
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 740.0
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 724.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 716.1
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 705.5
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 705.3
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 699.9
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 690.2
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 688.0
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 680.0
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 679.8
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 677.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 673.2
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 663.5
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 662.6
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 662.4
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 660.5
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 654.6
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 645.0
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 635.7
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 619.1
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 614.5
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 612.3
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 605.6
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 605.1
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 598.0
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 597.4
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 595.3
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 592.7
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 588.3
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 588.0
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 586.5
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 583.5
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 583.3
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 582.2
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 580.9
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 580.8
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 580.4
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 580.4
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 577.3
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 574.7
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 569.8
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 565.6
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 551.8
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 551.3
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 551.3
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 543.7
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 540.1
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 534.4
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 529.6
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 528.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 526.0
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 517.9
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 513.3
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 512.9
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 509.1
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 507.0
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 503.1
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 500.9
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 492.8
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 492.2
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 488.3
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 485.5
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 480.1
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 479.6
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 475.4
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 474.8
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 474.0
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 473.1
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 469.8
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 465.7
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 461.5
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 459.9
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 459.9
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 457.6
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 455.3
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 454.7
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 449.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 443.8
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 441.0
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 439.4
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 432.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 432.6
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 432.3
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 431.3
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 430.1
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 430.1
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 425.4
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 421.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 421.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 419.9
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 419.8
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 417.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 414.5
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 412.7
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 394.4
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 392.8
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 390.3
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 389.8
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 388.9
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 387.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 383.2
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 381.2
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 378.9
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 377.2
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 376.8
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 374.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 369.1
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 368.5
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 365.9
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 350.3
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 349.7
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 349.1
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 338.9
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 328.8
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 325.8
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 320.0
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 313.2
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 310.8
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 301.9
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 299.4
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 277.0
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 217.6
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 695.2
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 695.2
FF:10158-103A5 76 years, female 695.2

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 208.7
Pig sample Sample description nTPM
Midbrain
nTPM: 208.7
Samples: 4

Max nTPM: 452.0
Min nTPM: 114.1
Sample A Female 452.0
Sample B Female 152.5
Sample C Male 114.1
Sample D Male 116.1
Periaqueductal gray
nTPM: 118.2
Samples: 3

Max nTPM: 133.1
Min nTPM: 107.5
Sample B Female 133.1
Sample C Male 107.5
Sample D Male 114.1
Substantia nigra
nTPM: 157.9
Samples: 4

Max nTPM: 224.2
Min nTPM: 100.3
Sample A Female 173.4
Sample B Female 100.3
Sample C Male 133.6
Sample D Male 224.2
Superior colliculi
nTPM: 148.9
Samples: 4

Max nTPM: 176.9
Min nTPM: 87.9
Sample A Female 175.1
Sample B Female 87.9
Sample C Male 155.7
Sample D Male 176.9

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 477.0
Mouse sample Sample description nTPM
Midbrain
nTPM: 477.0
Samples: 4

Max nTPM: 495.6
Min nTPM: 468.9
Sample A Male 470.0
Sample B Male 468.9
Sample C Female 473.5
Sample D Female 495.6

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 17.7
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 17.7
68632051 Antisense, RP_050125_01_F03, Mouse strain C57BL/6J (56 days, male) 17.7

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