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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
CD markers Disease related genes Enzymes Human disease related genes Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
p25.1
Chromosome location (bp)
9488486 - 9556732
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
ADAM17-201
ADAM17-207
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P78536 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 17 B2RNB2 [Target identity:100%; Query identity:100%] ADAM metallopeptidase domain 17; ADAM metallopeptidase domain 17 (Tumor necrosis factor, alpha, converting enzyme), isoform CRA_b; ADAM metallopeptidase domain 18
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Enzymes ENZYME proteins Hydrolases CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia] GO:0001934 [positive regulation of protein phosphorylation] GO:0002446 [neutrophil mediated immunity] GO:0002467 [germinal center formation] GO:0002690 [positive regulation of leukocyte chemotaxis] GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005112 [Notch binding] GO:0005138 [interleukin-6 receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0006509 [membrane protein ectodomain proteolysis] GO:0007155 [cell adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0007220 [Notch receptor processing] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0008284 [positive regulation of cell population proliferation] GO:0009986 [cell surface] GO:0010820 [positive regulation of T cell chemotaxis] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0016485 [protein processing] GO:0016787 [hydrolase activity] GO:0017124 [SH3 domain binding] GO:0030165 [PDZ domain binding] GO:0030183 [B cell differentiation] GO:0030307 [positive regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0032496 [response to lipopolysaccharide] GO:0032587 [ruffle membrane] GO:0032722 [positive regulation of chemokine production] GO:0033025 [regulation of mast cell apoptotic process] GO:0033077 [T cell differentiation in thymus] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0033627 [cell adhesion mediated by integrin] GO:0035313 [wound healing, spreading of epidermal cells] GO:0035624 [receptor transactivation] GO:0042493 [response to drug] GO:0042987 [amyloid precursor protein catabolic process] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045121 [membrane raft] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] GO:0046872 [metal ion binding] GO:0048536 [spleen development] GO:0048870 [cell motility] GO:0050830 [defense response to Gram-positive bacterium] GO:0051272 [positive regulation of cellular component movement] GO:0071403 [cellular response to high density lipoprotein particle stimulus] GO:0120163 [negative regulation of cold-induced thermogenesis] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] GO:1902945 [metalloendopeptidase activity involved in amyloid precursor protein catabolic process] GO:1903265 [positive regulation of tumor necrosis factor-mediated signaling pathway] GO:1905564 [positive regulation of vascular endothelial cell proliferation]
A0A3B3ISQ1 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 17
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
