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HNRNPU
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  • HNRNPU
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

HNRNPU
Synonyms C1orf199, FLJ30202, FLJ37978, HNRNPU-AS1, HNRPU, NCRNA00201, SAF-A
Gene descriptioni

Full gene name according to HGNC.

Heterogeneous nuclear ribonucleoprotein U
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Disease related genes
Human disease related genes
Plasma proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 1
Cytoband q44
Chromosome location (bp) 244840638 - 244864560
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

10
Ensembl ENSG00000153187 (version 103.38)
Entrez gene 3192
HGNC HGNC:5048
UniProt Q00839 (UniProt - Evidence at protein level)
neXtProt NX_Q00839
Antibodypedia HNRNPU antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 1      # Population variants: 323

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
HNRNPU-201
HNRNPU-204
HNRNPU-205
HNRNPU-210
HNRNPU-214
HNRNPU-216
HNRNPU-219
HNRNPU-221
HNRNPU-223
HNRNPU-226


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
HNRNPU-201
ENSP00000283179
ENST00000283179
A0A1X7SBS1 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein U
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Epilepsy
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
Show all
744 aa
81.8 kDa
No 0
HNRNPU-204
ENSP00000410728
ENST00000440865
Q5RI18 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein U
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Epilepsy
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
Show all
602 aa
67.8 kDa
No 0
HNRNPU-205
ENSP00000393151
ENST00000444376
Q00839 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein U
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Nervous system diseases
   Epilepsy
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0000228 [nuclear chromosome]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000922 [spindle pole]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000993 [RNA polymerase II complex binding]
GO:0001097 [TFIIH-class transcription factor complex binding]
GO:0001649 [osteoblast differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005694 [chromosome]
GO:0005697 [telomerase holoenzyme complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005856 [cytoskeleton]
GO:0006325 [chromatin organization]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0007049 [cell cycle]
GO:0007275 [multicellular organism development]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008143 [poly(A) binding]
GO:0008380 [RNA splicing]
GO:0009048 [dosage compensation by inactivation of X chromosome]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016070 [RNA metabolic process]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0017069 [snRNA binding]
GO:0017130 [poly(C) RNA binding]
GO:0030154 [cell differentiation]
GO:0030496 [midbody]
GO:0031490 [chromatin DNA binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032839 [dendrite cytoplasm]
GO:0032922 [circadian regulation of gene expression]
GO:0032991 [protein-containing complex]
GO:0033673 [negative regulation of kinase activity]
GO:0034046 [poly(G) binding]
GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter]
GO:0036002 [pre-mRNA binding]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0042802 [identical protein binding]
GO:0043021 [ribonucleoprotein complex binding]
GO:0044877 [protein-containing complex binding]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048255 [mRNA stabilization]
GO:0048511 [rhythmic process]
GO:0051301 [cell division]
GO:0051457 [maintenance of protein location in nucleus]
GO:0070034 [telomerase RNA binding]
GO:0070934 [CRD-mediated mRNA stabilization]
GO:0070937 [CRD-mediated mRNA stability complex]
GO:0071013 [catalytic step 2 spliceosome]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0072686 [mitotic spindle]
GO:0090336 [positive regulation of brown fat cell differentiation]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098577 [inactive sex chromosome]
GO:0099122 [RNA polymerase II C-terminal domain binding]
GO:1901673 [regulation of mitotic spindle assembly]
GO:1902275 [regulation of chromatin organization]
GO:1902425 [positive regulation of attachment of mitotic spindle microtubules to kinetochore]
GO:1902889 [protein localization to spindle microtubule]
GO:1990023 [mitotic spindle midzone]
GO:1990280 [RNA localization to chromatin]
GO:1990498 [mitotic spindle microtubule]
GO:1990830 [cellular response to leukemia inhibitory factor]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
GO:1990845 [adaptive thermogenesis]
GO:1990904 [ribonucleoprotein complex]
GO:2000373 [positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity]
GO:2000648 [positive regulation of stem cell proliferation]
GO:2000737 [negative regulation of stem cell differentiation]
Show all
806 aa
89 kDa
No 0
HNRNPU-210
ENSP00000492573
ENST00000483966
A0A1W2PRZ7 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein U
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Epilepsy
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
Show all
302 aa
34.2 kDa
No 0
HNRNPU-214
ENSP00000491305
ENST00000638475
A0A1W2PP35 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein U
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Epilepsy
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
Show all
728 aa
80.6 kDa
No 0
HNRNPU-216
ENSP00000491601
ENST00000638716
A0A1W2PPL4 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein U
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Epilepsy
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
Show all
547 aa
61.6 kDa
No 0
HNRNPU-219
ENSP00000491340
ENST00000639628
A0A1W2PPH7 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein U
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Epilepsy
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
Show all
549 aa
61.7 kDa
No 0
HNRNPU-221
ENSP00000491903
ENST00000639824
A0A1W2PQD4 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein U
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Epilepsy
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
Show all
327 aa
36.3 kDa
No 0
HNRNPU-223
ENSP00000491294
ENST00000640001
A0A1W2PP34 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein U
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Epilepsy
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
Show all
546 aa
61.1 kDa
No 0
HNRNPU-226
ENSP00000491215
ENST00000640218
Q00839 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein U
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Nervous system diseases
   Epilepsy
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0000228 [nuclear chromosome]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000922 [spindle pole]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000993 [RNA polymerase II complex binding]
GO:0001097 [TFIIH-class transcription factor complex binding]
GO:0001649 [osteoblast differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005694 [chromosome]
GO:0005697 [telomerase holoenzyme complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005856 [cytoskeleton]
GO:0006325 [chromatin organization]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0007049 [cell cycle]
GO:0007275 [multicellular organism development]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008143 [poly(A) binding]
GO:0008380 [RNA splicing]
GO:0009048 [dosage compensation by inactivation of X chromosome]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016070 [RNA metabolic process]
GO:0016071 [mRNA metabolic process]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0017069 [snRNA binding]
GO:0017130 [poly(C) RNA binding]
GO:0030154 [cell differentiation]
GO:0030496 [midbody]
GO:0031490 [chromatin DNA binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032839 [dendrite cytoplasm]
GO:0032922 [circadian regulation of gene expression]
GO:0032991 [protein-containing complex]
GO:0033673 [negative regulation of kinase activity]
GO:0034046 [poly(G) binding]
GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter]
GO:0036002 [pre-mRNA binding]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0042802 [identical protein binding]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044877 [protein-containing complex binding]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048255 [mRNA stabilization]
GO:0048511 [rhythmic process]
GO:0051301 [cell division]
GO:0051457 [maintenance of protein location in nucleus]
GO:0055013 [cardiac muscle cell development]
GO:0070034 [telomerase RNA binding]
GO:0070934 [CRD-mediated mRNA stabilization]
GO:0070937 [CRD-mediated mRNA stability complex]
GO:0071013 [catalytic step 2 spliceosome]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0072686 [mitotic spindle]
GO:0090336 [positive regulation of brown fat cell differentiation]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0098577 [inactive sex chromosome]
GO:0098963 [dendritic transport of messenger ribonucleoprotein complex]
GO:0099122 [RNA polymerase II C-terminal domain binding]
GO:1901673 [regulation of mitotic spindle assembly]
GO:1902275 [regulation of chromatin organization]
GO:1902425 [positive regulation of attachment of mitotic spindle microtubules to kinetochore]
GO:1902889 [protein localization to spindle microtubule]
GO:1990023 [mitotic spindle midzone]
GO:1990280 [RNA localization to chromatin]
GO:1990498 [mitotic spindle microtubule]
GO:1990830 [cellular response to leukemia inhibitory factor]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
GO:1990845 [adaptive thermogenesis]
GO:1990904 [ribonucleoprotein complex]
GO:2000373 [positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity]
GO:2000648 [positive regulation of stem cell proliferation]
GO:2000737 [negative regulation of stem cell differentiation]
Show all
825 aa
90.6 kDa
No 0

Contact

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  • PRESS ROOM
  • contact@proteinatlas.org

The Project

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  • PUBLICATIONS

The Human Protein Atlas

  • DOWNLOADABLE DATA
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  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.