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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Human disease related genes Nuclear receptors Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q24.1
Chromosome location (bp)
156324437 - 156342348
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
NR4A2-201
NR4A2-202
NR4A2-203
NR4A2-204
NR4A2-207
NR4A2-208
NR4A2-209
NR4A2-210
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P43354 [Direct mapping] Nuclear receptor subfamily 4 group A member 2 F1D8N6 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 2
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Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001666 [response to hypoxia] GO:0001764 [neuron migration] GO:0001975 [response to amphetamine] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007399 [nervous system development] GO:0008013 [beta-catenin binding] GO:0008270 [zinc ion binding] GO:0008344 [adult locomotory behavior] GO:0009791 [post-embryonic development] GO:0010467 [gene expression] GO:0010468 [regulation of gene expression] GO:0016607 [nuclear speck] GO:0021952 [central nervous system projection neuron axonogenesis] GO:0021953 [central nervous system neuron differentiation] GO:0021986 [habenula development] GO:0030182 [neuron differentiation] GO:0030522 [intracellular receptor signaling pathway] GO:0031668 [cellular response to extracellular stimulus] GO:0032991 [protein-containing complex] GO:0034599 [cellular response to oxidative stress] GO:0035259 [glucocorticoid receptor binding] GO:0042053 [regulation of dopamine metabolic process] GO:0042416 [dopamine biosynthetic process] GO:0042417 [dopamine metabolic process] GO:0042551 [neuron maturation] GO:0043085 [positive regulation of catalytic activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0043576 [regulation of respiratory gaseous exchange] GO:0045444 [fat cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0046982 [protein heterodimerization activity] GO:0051866 [general adaptation syndrome] GO:0060070 [canonical Wnt signaling pathway] GO:0071376 [cellular response to corticotropin-releasing hormone stimulus] GO:0071542 [dopaminergic neuron differentiation] GO:1904948 [midbrain dopaminergic neuron differentiation] GO:1990837 [sequence-specific double-stranded DNA binding] GO:2001234 [negative regulation of apoptotic signaling pathway]
H7BZ00 [Direct mapping] Nuclear receptor subfamily 4 group A member 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases
F8W6I3 [Direct mapping] Nuclear receptor subfamily 4 group A member 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases
P43354 [Direct mapping] Nuclear receptor subfamily 4 group A member 2 F1D8N6 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 2
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Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001764 [neuron migration] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008013 [beta-catenin binding] GO:0008270 [zinc ion binding] GO:0016607 [nuclear speck] GO:0021953 [central nervous system neuron differentiation] GO:0030522 [intracellular receptor signaling pathway] GO:0031668 [cellular response to extracellular stimulus] GO:0032991 [protein-containing complex] GO:0035259 [glucocorticoid receptor binding] GO:0043565 [sequence-specific DNA binding] GO:0045444 [fat cell differentiation] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0046982 [protein heterodimerization activity] GO:0060070 [canonical Wnt signaling pathway] GO:0071376 [cellular response to corticotropin-releasing hormone stimulus] GO:0071542 [dopaminergic neuron differentiation] GO:1904948 [midbrain dopaminergic neuron differentiation] GO:1990837 [sequence-specific double-stranded DNA binding] GO:2001234 [negative regulation of apoptotic signaling pathway]
C9JWQ1 [Direct mapping] Nuclear receptor subfamily 4 group A member 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases
C9IYM5 [Direct mapping] Nuclear receptor subfamily 4 group A member 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases
P43354 [Direct mapping] Nuclear receptor subfamily 4 group A member 2
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Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001764 [neuron migration] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008013 [beta-catenin binding] GO:0008270 [zinc ion binding] GO:0016607 [nuclear speck] GO:0021953 [central nervous system neuron differentiation] GO:0030522 [intracellular receptor signaling pathway] GO:0031668 [cellular response to extracellular stimulus] GO:0032991 [protein-containing complex] GO:0035259 [glucocorticoid receptor binding] GO:0043565 [sequence-specific DNA binding] GO:0045444 [fat cell differentiation] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0046982 [protein heterodimerization activity] GO:0060070 [canonical Wnt signaling pathway] GO:0071376 [cellular response to corticotropin-releasing hormone stimulus] GO:0071542 [dopaminergic neuron differentiation] GO:1904948 [midbrain dopaminergic neuron differentiation] GO:1990837 [sequence-specific double-stranded DNA binding] GO:2001234 [negative regulation of apoptotic signaling pathway]
C9J8W4 [Direct mapping] Nuclear receptor subfamily 4 group A member 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Neurodegenerative diseases
The Human Protein Atlas project is funded
