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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:495.1 nTPM
HPA:495.1 nTPM
GTEx:510.9 nTPM
FANTOM5:622.2 Scaled Tags Per Million
Pig:83.5 nTPM
Mouse:863.3 nTPM
Allen mouse:6.4 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 495.1
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 469.1
2828 Female, age 72, unknown 494.8
1870 Female, age 42, unknown 486.5
1827 Male, age 72, unknown 467.4
1833 Male, age 53, unknown 467.2
2666 Male, age 74, left hemisphere 466.9
1830 Male, age 51, unknown 464.9
2219 Male, age 76, both hemispheres 464.8
2019 Male, age 18, unknown 463.5
2411 Female, age 72, unknown 463.4
2586 Male, age 75, left hemisphere 451.8
Dorsal raphe nucleus
nTPM: 480.0
2016 Female, age 72, unknown 488.3
2298 Female, age 72, unknown 485.7
2047 Male, age 72, unknown 476.5
2750 Male, age 76, both hemispheres 475.9
1828 Male, age 53, unknown 473.7
Inferior colliculus
nTPM: 476.6
2849 Male, age 72, unknown 478.8
2097 Female, age 72, unknown 478.5
1848 Female, age 42, unknown 475.8
1890 Male, age 53, unknown 473.5
Median raphe nucleus
nTPM: 489.2
2220 Male, age 76, midline 489.2
Pedunculopontine tegmental nucleus
nTPM: 487.6
2338 Male, age 61, both hemispheres 501.9
2334 Male, age 80, both hemispheres 492.0
1921 Female, age 85, both hemispheres 468.8
Periaquaductal grey, anterior
nTPM: 469.7
1795 Male, age 51, unknown 477.7
1947 Male, age 18, unknown 468.1
2502 Female, age 75, unknown 463.4
Periaquaductal grey, dorsal
nTPM: 495.1
2850 Male, age 76, both hemispheres 543.2
1840 Male, age 53, unknown 482.1
1831 Male, age 72, unknown 481.7
2464 Female, age 72, unknown 473.5
Periaquaductal grey, lateral
nTPM: 494.4
2140 Male, age 76, both hemispheres 514.7
2053 Male, age 18, unknown 499.1
2272 Male, age 74, both hemispheres 469.3
Pretectal area
nTPM: 483.6
2273 Male, age 74, both hemispheres 502.9
2316 Male, age 76, right hemisphere 495.6
2667 Female, age 75, unknown 491.5
2224 Female, age 72, unknown 490.7
2407 Male, age 75, both hemispheres 488.0
1817 Female, age 42, unknown 483.9
1815 Male, age 53, unknown 480.9
1944 Female, age 72, unknown 478.7
2825 Male, age 18, unknown 478.4
1816 Male, age 51, unknown 465.6
2007 Male, age 72, unknown 463.4
Red nucleus
nTPM: 471.5
2725 Female, age 75, unknown 496.8
1865 Male, age 51, unknown 484.2
1954 Female, age 42, unknown 482.5
2503 Female, age 72, unknown 482.3
1904 Male, age 53, unknown 474.5
2823 Male, age 76, right hemisphere 472.6
2769 Male, age 72, unknown 472.0
2227 Male, age 72, unknown 469.4
2785 Male, age 18, unknown 468.6
1821 Female, age 72, unknown 466.1
2584 Male, age 75, left hemisphere 445.8
2588 Male, age 74, left hemisphere 443.6
Substantia nigra
nTPM: 465.2
2699 Male, age 18, unknown 483.2
1941 Male, age 53, unknown 476.1
1889 Female, age 72, unknown 470.4
2241 Male, age 72, unknown 468.4
1851 Male, age 51, unknown 465.2
1916 Female, age 42, unknown 463.2
2409 Female, age 72, unknown 459.5
2665 Male, age 74, both hemispheres 456.8
2590 Female, age 75, unknown 454.5
2583 Male, age 75, right hemisphere 454.4
Superior colliculus
nTPM: 478.8
1995 Male, age 72, unknown 506.1
1913 Female, age 42, unknown 497.7
2587 Male, age 74, left hemisphere 483.2
2087 Female, age 72, unknown 476.6
1796 Male, age 53, unknown 475.6
1839 Male, age 51, unknown 473.0
2664 Male, age 75, both hemispheres 472.7
1895 Male, age 76, right hemisphere 471.3
2668 Female, age 75, unknown 466.7
2261 Male, age 18, unknown 465.5
Ventral tegmental area
nTPM: 479.4
2223 Female, age 72, unknown 489.2
2021 Male, age 53, unknown 482.6
1942 Male, age 51, unknown 481.1
1915 Female, age 42, unknown 481.0
2218 Male, age 76, both hemispheres 474.2
2410 Female, age 72, unknown 468.4

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 510.9
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 510.9
Samples: 139

Max nTPM: 1256.1
Min nTPM: 223.1
Std nTPM: 188.8
Median nTPM: 457.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 1256.1
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 1079.1
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 1020.4
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 950.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 946.8
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 941.6
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 913.8
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 910.3
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 866.7
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 866.4
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 838.0
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 775.2
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 770.7
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 769.6
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 760.1
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 760.1
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 755.9
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 754.3
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 750.4
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 746.8
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 742.1
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 738.0
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 737.2
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 733.6
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 678.2
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 664.2
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 646.2
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 623.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 621.8
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 620.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 605.3
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 603.4
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 601.3
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 599.3
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 589.1
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 587.0
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 585.4
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 578.4
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 578.2
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 573.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 571.1
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 570.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 569.9
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 568.6
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 559.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 553.8
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 546.2
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 537.7
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 523.2
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 523.0
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 519.6
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 516.2
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 513.9
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 497.1
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 496.7
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 496.4
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 495.6
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 494.7
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 494.2
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 489.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 488.8
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 488.0
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 482.7
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 473.6
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 471.2
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 469.0
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 468.7
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 461.8
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 459.6
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 457.0
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 455.8
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 453.5
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 451.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 449.8
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 448.6
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 447.8
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 447.1
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 446.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 441.3
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 438.7
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 437.6
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 437.0
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 431.5
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 431.1
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 429.4
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 428.4
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 425.7
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 424.8
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 423.2
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 422.1
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 418.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 415.9
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 415.4
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 411.1
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 406.8
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 405.3
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 403.9
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 394.8
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 387.4
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 384.6
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 384.4
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 380.1
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 375.8
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 371.8
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 371.3
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 368.4
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 368.3
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 363.5
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 362.2
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 360.9
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 360.1
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 359.5
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 354.0
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 353.4
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 348.4
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 347.0
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 343.6
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 342.2
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 341.9
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 340.6
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 337.9
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 333.9
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 332.6
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 327.2
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 325.5
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 324.3
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 323.6
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 319.2
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 304.3
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 299.2
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 295.4
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 293.0
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 285.4
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 279.5
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 277.2
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 260.8
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 232.2
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 227.1
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 223.1
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 622.2
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 622.2
FF:10158-103A5 76 years, female 622.2

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 83.5
Pig sample Sample description nTPM
Midbrain
nTPM: 78.5
Samples: 4

Max nTPM: 119.1
Min nTPM: 52.7
Sample A Female 119.1
Sample B Female 89.0
Sample C Male 53.1
Sample D Male 52.7
Periaqueductal gray
nTPM: 68.6
Samples: 3

Max nTPM: 71.2
Min nTPM: 65.8
Sample B Female 71.2
Sample C Male 68.9
Sample D Male 65.8
Substantia nigra
nTPM: 83.6
Samples: 4

Max nTPM: 112.9
Min nTPM: 69.6
Sample A Female 112.9
Sample B Female 69.6
Sample C Male 71.4
Sample D Male 80.4
Superior colliculi
nTPM: 64.4
Samples: 4

Max nTPM: 83.8
Min nTPM: 38.6
Sample A Female 83.8
Sample B Female 38.6
Sample C Male 69.2
Sample D Male 66.1

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 863.3
Mouse sample Sample description nTPM
Midbrain
nTPM: 863.3
Samples: 4

Max nTPM: 935.3
Min nTPM: 790.7
Sample A Male 935.3
Sample B Male 814.3
Sample C Female 790.7
Sample D Female 912.7

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 6.4
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 6.4
71836880 Antisense, RP_051017_02_E10, Mouse strain C57BL/6J (56 days, male) 9.0
68632649 Antisense, RP_050125_02_A01, Mouse strain C57BL/6J (56 days, male) 3.9

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