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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p25.3
Chromosome location (bp)
10285666 - 10292947
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Human disease related genes Endocrine and metabolic diseases Other endocrine and metabolic diseases Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001664 [G protein-coupled receptor binding] GO:0001696 [gastric acid secretion] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006006 [glucose metabolic process] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008154 [actin polymerization or depolymerization] GO:0008343 [adult feeding behavior] GO:0009725 [response to hormone] GO:0009755 [hormone-mediated signaling pathway] GO:0016358 [dendrite development] GO:0016525 [negative regulation of angiogenesis] GO:0016608 [growth hormone-releasing hormone activity] GO:0030252 [growth hormone secretion] GO:0030296 [protein tyrosine kinase activator activity] GO:0030424 [axon] GO:0031768 [ghrelin receptor binding] GO:0032024 [positive regulation of insulin secretion] GO:0032095 [regulation of response to food] GO:0032100 [positive regulation of appetite] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034774 [secretory granule lumen] GO:0040018 [positive regulation of multicellular organism growth] GO:0042127 [regulation of cell population proliferation] GO:0042322 [negative regulation of circadian sleep/wake cycle, REM sleep] GO:0043066 [negative regulation of apoptotic process] GO:0043400 [cortisol secretion] GO:0043627 [response to estrogen] GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep] GO:0046697 [decidualization] GO:0050728 [negative regulation of inflammatory response] GO:0051216 [cartilage development] GO:0051461 [positive regulation of corticotropin secretion] GO:0051464 [positive regulation of cortisol secretion] GO:0051965 [positive regulation of synapse assembly] GO:0060124 [positive regulation of growth hormone secretion] GO:0060399 [positive regulation of growth hormone receptor signaling pathway] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0098794 [postsynapse] GO:0120162 [positive regulation of cold-induced thermogenesis]
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Human disease related genes Endocrine and metabolic diseases Other endocrine and metabolic diseases Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001664 [G protein-coupled receptor binding] GO:0001696 [gastric acid secretion] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005788 [endoplasmic reticulum lumen] GO:0006006 [glucose metabolic process] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008154 [actin polymerization or depolymerization] GO:0008343 [adult feeding behavior] GO:0009725 [response to hormone] GO:0009755 [hormone-mediated signaling pathway] GO:0016358 [dendrite development] GO:0016525 [negative regulation of angiogenesis] GO:0016608 [growth hormone-releasing hormone activity] GO:0030252 [growth hormone secretion] GO:0030296 [protein tyrosine kinase activator activity] GO:0030424 [axon] GO:0031667 [response to nutrient levels] GO:0031768 [ghrelin receptor binding] GO:0032024 [positive regulation of insulin secretion] GO:0032095 [regulation of response to food] GO:0032097 [positive regulation of response to food] GO:0032100 [positive regulation of appetite] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034774 [secretory granule lumen] GO:0035483 [gastric emptying] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0040010 [positive regulation of growth rate] GO:0040013 [negative regulation of locomotion] GO:0040018 [positive regulation of multicellular organism growth] GO:0042127 [regulation of cell population proliferation] GO:0042322 [negative regulation of circadian sleep/wake cycle, REM sleep] GO:0043066 [negative regulation of apoptotic process] GO:0043400 [cortisol secretion] GO:0043627 [response to estrogen] GO:0045927 [positive regulation of growth] GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep] GO:0046676 [negative regulation of insulin secretion] GO:0046697 [decidualization] GO:0050728 [negative regulation of inflammatory response] GO:0051216 [cartilage development] GO:0051461 [positive regulation of corticotropin secretion] GO:0051464 [positive regulation of cortisol secretion] GO:0051602 [response to electrical stimulus] GO:0051965 [positive regulation of synapse assembly] GO:0051969 [regulation of transmission of nerve impulse] GO:0060079 [excitatory postsynaptic potential] GO:0060124 [positive regulation of growth hormone secretion] GO:0060399 [positive regulation of growth hormone receptor signaling pathway] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0098685 [Schaffer collateral - CA1 synapse] GO:0098794 [postsynapse] GO:0098978 [glutamatergic synapse] GO:0099170 [postsynaptic modulation of chemical synaptic transmission] GO:0099175 [regulation of postsynapse organization] GO:0120058 [positive regulation of small intestinal transit] GO:0120162 [positive regulation of cold-induced thermogenesis] GO:1903012 [positive regulation of bone development] GO:1903672 [positive regulation of sprouting angiogenesis] GO:1904000 [positive regulation of eating behavior] GO:1904179 [positive regulation of adipose tissue development] GO:1904306 [positive regulation of gastro-intestinal system smooth muscle contraction] GO:1904346 [positive regulation of gastric mucosal blood circulation] GO:1904349 [positive regulation of small intestine smooth muscle contraction] GO:1905333 [regulation of gastric motility] GO:1905564 [positive regulation of vascular endothelial cell proliferation] GO:2000253 [positive regulation of feeding behavior]
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Human disease related genes Endocrine and metabolic diseases Other endocrine and metabolic diseases Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001664 [G protein-coupled receptor binding] GO:0001696 [gastric acid secretion] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006006 [glucose metabolic process] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008154 [actin polymerization or depolymerization] GO:0008343 [adult feeding behavior] GO:0009725 [response to hormone] GO:0009755 [hormone-mediated signaling pathway] GO:0016358 [dendrite development] GO:0016525 [negative regulation of angiogenesis] GO:0016608 [growth hormone-releasing hormone activity] GO:0030252 [growth hormone secretion] GO:0030296 [protein tyrosine kinase activator activity] GO:0030424 [axon] GO:0031768 [ghrelin receptor binding] GO:0032024 [positive regulation of insulin secretion] GO:0032095 [regulation of response to food] GO:0032100 [positive regulation of appetite] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034774 [secretory granule lumen] GO:0040018 [positive regulation of multicellular organism growth] GO:0042127 [regulation of cell population proliferation] GO:0042322 [negative regulation of circadian sleep/wake cycle, REM sleep] GO:0043066 [negative regulation of apoptotic process] GO:0043400 [cortisol secretion] GO:0043627 [response to estrogen] GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep] GO:0046697 [decidualization] GO:0050728 [negative regulation of inflammatory response] GO:0051216 [cartilage development] GO:0051461 [positive regulation of corticotropin secretion] GO:0051464 [positive regulation of cortisol secretion] GO:0051965 [positive regulation of synapse assembly] GO:0060124 [positive regulation of growth hormone secretion] GO:0060399 [positive regulation of growth hormone receptor signaling pathway] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0098794 [postsynapse] GO:0120162 [positive regulation of cold-induced thermogenesis]
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Human disease related genes Endocrine and metabolic diseases Other endocrine and metabolic diseases Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001664 [G protein-coupled receptor binding] GO:0001696 [gastric acid secretion] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006006 [glucose metabolic process] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008154 [actin polymerization or depolymerization] GO:0008343 [adult feeding behavior] GO:0009725 [response to hormone] GO:0009755 [hormone-mediated signaling pathway] GO:0016358 [dendrite development] GO:0016525 [negative regulation of angiogenesis] GO:0016608 [growth hormone-releasing hormone activity] GO:0030252 [growth hormone secretion] GO:0030296 [protein tyrosine kinase activator activity] GO:0030424 [axon] GO:0031768 [ghrelin receptor binding] GO:0032024 [positive regulation of insulin secretion] GO:0032095 [regulation of response to food] GO:0032100 [positive regulation of appetite] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034774 [secretory granule lumen] GO:0040018 [positive regulation of multicellular organism growth] GO:0042127 [regulation of cell population proliferation] GO:0042322 [negative regulation of circadian sleep/wake cycle, REM sleep] GO:0043066 [negative regulation of apoptotic process] GO:0043400 [cortisol secretion] GO:0043627 [response to estrogen] GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep] GO:0046697 [decidualization] GO:0050728 [negative regulation of inflammatory response] GO:0051216 [cartilage development] GO:0051461 [positive regulation of corticotropin secretion] GO:0051464 [positive regulation of cortisol secretion] GO:0051965 [positive regulation of synapse assembly] GO:0060124 [positive regulation of growth hormone secretion] GO:0060399 [positive regulation of growth hormone receptor signaling pathway] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0098794 [postsynapse] GO:0120162 [positive regulation of cold-induced thermogenesis]
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Human disease related genes Endocrine and metabolic diseases Other endocrine and metabolic diseases Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001664 [G protein-coupled receptor binding] GO:0001696 [gastric acid secretion] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006006 [glucose metabolic process] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008154 [actin polymerization or depolymerization] GO:0008343 [adult feeding behavior] GO:0009725 [response to hormone] GO:0009755 [hormone-mediated signaling pathway] GO:0016358 [dendrite development] GO:0016525 [negative regulation of angiogenesis] GO:0016608 [growth hormone-releasing hormone activity] GO:0030252 [growth hormone secretion] GO:0030296 [protein tyrosine kinase activator activity] GO:0030424 [axon] GO:0031768 [ghrelin receptor binding] GO:0032024 [positive regulation of insulin secretion] GO:0032095 [regulation of response to food] GO:0032100 [positive regulation of appetite] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034774 [secretory granule lumen] GO:0040018 [positive regulation of multicellular organism growth] GO:0042127 [regulation of cell population proliferation] GO:0042322 [negative regulation of circadian sleep/wake cycle, REM sleep] GO:0043066 [negative regulation of apoptotic process] GO:0043400 [cortisol secretion] GO:0043627 [response to estrogen] GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep] GO:0046697 [decidualization] GO:0050728 [negative regulation of inflammatory response] GO:0051216 [cartilage development] GO:0051461 [positive regulation of corticotropin secretion] GO:0051464 [positive regulation of cortisol secretion] GO:0051965 [positive regulation of synapse assembly] GO:0060124 [positive regulation of growth hormone secretion] GO:0060399 [positive regulation of growth hormone receptor signaling pathway] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0098794 [postsynapse] GO:0120162 [positive regulation of cold-induced thermogenesis]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Human disease related genes Endocrine and metabolic diseases Other endocrine and metabolic diseases Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001664 [G protein-coupled receptor binding] GO:0001696 [gastric acid secretion] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006006 [glucose metabolic process] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008154 [actin polymerization or depolymerization] GO:0008343 [adult feeding behavior] GO:0009725 [response to hormone] GO:0009755 [hormone-mediated signaling pathway] GO:0016358 [dendrite development] GO:0016525 [negative regulation of angiogenesis] GO:0016608 [growth hormone-releasing hormone activity] GO:0030252 [growth hormone secretion] GO:0030296 [protein tyrosine kinase activator activity] GO:0030424 [axon] GO:0031768 [ghrelin receptor binding] GO:0032024 [positive regulation of insulin secretion] GO:0032095 [regulation of response to food] GO:0032100 [positive regulation of appetite] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034774 [secretory granule lumen] GO:0040018 [positive regulation of multicellular organism growth] GO:0042127 [regulation of cell population proliferation] GO:0042322 [negative regulation of circadian sleep/wake cycle, REM sleep] GO:0043066 [negative regulation of apoptotic process] GO:0043400 [cortisol secretion] GO:0043627 [response to estrogen] GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep] GO:0046697 [decidualization] GO:0050728 [negative regulation of inflammatory response] GO:0051216 [cartilage development] GO:0051461 [positive regulation of corticotropin secretion] GO:0051464 [positive regulation of cortisol secretion] GO:0051965 [positive regulation of synapse assembly] GO:0060124 [positive regulation of growth hormone secretion] GO:0060399 [positive regulation of growth hormone receptor signaling pathway] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0098794 [postsynapse] GO:0120162 [positive regulation of cold-induced thermogenesis]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Human disease related genes Endocrine and metabolic diseases Other endocrine and metabolic diseases Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001664 [G protein-coupled receptor binding] GO:0001696 [gastric acid secretion] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006006 [glucose metabolic process] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008154 [actin polymerization or depolymerization] GO:0008343 [adult feeding behavior] GO:0009725 [response to hormone] GO:0009755 [hormone-mediated signaling pathway] GO:0016358 [dendrite development] GO:0016525 [negative regulation of angiogenesis] GO:0016608 [growth hormone-releasing hormone activity] GO:0030252 [growth hormone secretion] GO:0030296 [protein tyrosine kinase activator activity] GO:0030424 [axon] GO:0031768 [ghrelin receptor binding] GO:0032024 [positive regulation of insulin secretion] GO:0032095 [regulation of response to food] GO:0032100 [positive regulation of appetite] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034774 [secretory granule lumen] GO:0040018 [positive regulation of multicellular organism growth] GO:0042127 [regulation of cell population proliferation] GO:0042322 [negative regulation of circadian sleep/wake cycle, REM sleep] GO:0043066 [negative regulation of apoptotic process] GO:0043400 [cortisol secretion] GO:0043627 [response to estrogen] GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep] GO:0046697 [decidualization] GO:0050728 [negative regulation of inflammatory response] GO:0051216 [cartilage development] GO:0051461 [positive regulation of corticotropin secretion] GO:0051464 [positive regulation of cortisol secretion] GO:0051965 [positive regulation of synapse assembly] GO:0060124 [positive regulation of growth hormone secretion] GO:0060399 [positive regulation of growth hormone receptor signaling pathway] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0098794 [postsynapse] GO:0120162 [positive regulation of cold-induced thermogenesis]
Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Human disease related genes Endocrine and metabolic diseases Other endocrine and metabolic diseases Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Human disease related genes Endocrine and metabolic diseases Other endocrine and metabolic diseases Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001664 [G protein-coupled receptor binding] GO:0001696 [gastric acid secretion] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006006 [glucose metabolic process] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008154 [actin polymerization or depolymerization] GO:0008343 [adult feeding behavior] GO:0009725 [response to hormone] GO:0009755 [hormone-mediated signaling pathway] GO:0016358 [dendrite development] GO:0016525 [negative regulation of angiogenesis] GO:0016608 [growth hormone-releasing hormone activity] GO:0030252 [growth hormone secretion] GO:0030296 [protein tyrosine kinase activator activity] GO:0030424 [axon] GO:0031768 [ghrelin receptor binding] GO:0032024 [positive regulation of insulin secretion] GO:0032095 [regulation of response to food] GO:0032100 [positive regulation of appetite] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034774 [secretory granule lumen] GO:0040018 [positive regulation of multicellular organism growth] GO:0042127 [regulation of cell population proliferation] GO:0042322 [negative regulation of circadian sleep/wake cycle, REM sleep] GO:0043066 [negative regulation of apoptotic process] GO:0043400 [cortisol secretion] GO:0043627 [response to estrogen] GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep] GO:0046697 [decidualization] GO:0050728 [negative regulation of inflammatory response] GO:0051216 [cartilage development] GO:0051461 [positive regulation of corticotropin secretion] GO:0051464 [positive regulation of cortisol secretion] GO:0051965 [positive regulation of synapse assembly] GO:0060124 [positive regulation of growth hormone secretion] GO:0060399 [positive regulation of growth hormone receptor signaling pathway] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0098794 [postsynapse] GO:0120162 [positive regulation of cold-induced thermogenesis]
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Human disease related genes Endocrine and metabolic diseases Other endocrine and metabolic diseases Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001664 [G protein-coupled receptor binding] GO:0001696 [gastric acid secretion] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006006 [glucose metabolic process] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008154 [actin polymerization or depolymerization] GO:0008343 [adult feeding behavior] GO:0009725 [response to hormone] GO:0009755 [hormone-mediated signaling pathway] GO:0016358 [dendrite development] GO:0016525 [negative regulation of angiogenesis] GO:0016608 [growth hormone-releasing hormone activity] GO:0030252 [growth hormone secretion] GO:0030296 [protein tyrosine kinase activator activity] GO:0030424 [axon] GO:0031768 [ghrelin receptor binding] GO:0032024 [positive regulation of insulin secretion] GO:0032095 [regulation of response to food] GO:0032100 [positive regulation of appetite] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034774 [secretory granule lumen] GO:0040018 [positive regulation of multicellular organism growth] GO:0042127 [regulation of cell population proliferation] GO:0042322 [negative regulation of circadian sleep/wake cycle, REM sleep] GO:0043066 [negative regulation of apoptotic process] GO:0043400 [cortisol secretion] GO:0043627 [response to estrogen] GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep] GO:0046697 [decidualization] GO:0050728 [negative regulation of inflammatory response] GO:0051216 [cartilage development] GO:0051461 [positive regulation of corticotropin secretion] GO:0051464 [positive regulation of cortisol secretion] GO:0051965 [positive regulation of synapse assembly] GO:0060124 [positive regulation of growth hormone secretion] GO:0060399 [positive regulation of growth hormone receptor signaling pathway] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0098794 [postsynapse] GO:0120162 [positive regulation of cold-induced thermogenesis]
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