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KIT
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  • KIT
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

KIT
Synonyms C-Kit, CD117, PBT, SCFR
Gene descriptioni

Full gene name according to HGNC.

KIT proto-oncogene, receptor tyrosine kinase
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
CD markers
Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Plasma proteins
RAS pathway related proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 4
Cytoband q12
Chromosome location (bp) 54657918 - 54740715
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

2
Ensembl ENSG00000157404 (version 103.38)
Entrez gene 3815
HGNC HGNC:6342
UniProt P10721 (UniProt - Evidence at protein level)
neXtProt NX_P10721
Antibodypedia KIT antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 53      # Population variants: 448

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
KIT-201
KIT-202


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
KIT-201
ENSP00000288135
ENST00000288135
P10721 [Direct mapping]
Mast/stem cell growth factor receptor Kit
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of haematopoietic and lymphoid tissues
   Congenital disorders of metabolism
   Congenital disorders of amino acid metabolism
   Immune system diseases
   Allergies and autoimmune diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000187 [activation of MAPK activity]
GO:0001541 [ovarian follicle development]
GO:0001650 [fibrillar center]
GO:0001669 [acrosomal vesicle]
GO:0002020 [protease binding]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0002318 [myeloid progenitor cell differentiation]
GO:0002320 [lymphoid progenitor cell differentiation]
GO:0002327 [immature B cell differentiation]
GO:0002371 [dendritic cell cytokine production]
GO:0002551 [mast cell chemotaxis]
GO:0002573 [myeloid leukocyte differentiation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005020 [stem cell factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006468 [protein phosphorylation]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organism development]
GO:0007283 [spermatogenesis]
GO:0007286 [spermatid development]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008354 [germ cell migration]
GO:0008360 [regulation of cell shape]
GO:0008542 [visual learning]
GO:0008584 [male gonad development]
GO:0009314 [response to radiation]
GO:0009897 [external side of plasma membrane]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019827 [stem cell population maintenance]
GO:0019955 [cytokine binding]
GO:0030032 [lamellipodium assembly]
GO:0030097 [hemopoiesis]
GO:0030183 [B cell differentiation]
GO:0030217 [T cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0030318 [melanocyte differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032762 [mast cell cytokine production]
GO:0033674 [positive regulation of kinase activity]
GO:0035019 [somatic stem cell population maintenance]
GO:0035162 [embryonic hemopoiesis]
GO:0035234 [ectopic germ cell programmed cell death]
GO:0035556 [intracellular signal transduction]
GO:0035701 [hematopoietic stem cell migration]
GO:0035855 [megakaryocyte development]
GO:0038093 [Fc receptor signaling pathway]
GO:0038109 [Kit signaling pathway]
GO:0038162 [erythropoietin-mediated signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042169 [SH2 domain binding]
GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein]
GO:0042803 [protein homodimerization activity]
GO:0043069 [negative regulation of programmed cell death]
GO:0043235 [receptor complex]
GO:0043303 [mast cell degranulation]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043473 [pigmentation]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0043586 [tongue development]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0046427 [positive regulation of receptor signaling pathway via JAK-STAT]
GO:0046686 [response to cadmium ion]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048066 [developmental pigmentation]
GO:0048103 [somatic stem cell division]
GO:0048170 [positive regulation of long-term neuronal synaptic plasticity]
GO:0048565 [digestive tract development]
GO:0048863 [stem cell differentiation]
GO:0050673 [epithelial cell proliferation]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060326 [cell chemotaxis]
GO:0060374 [mast cell differentiation]
GO:0070662 [mast cell proliferation]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:0097324 [melanocyte migration]
GO:0097326 [melanocyte adhesion]
GO:0120072 [positive regulation of pyloric antrum smooth muscle contraction]
GO:1904251 [regulation of bile acid metabolic process]
GO:1904343 [positive regulation of colon smooth muscle contraction]
GO:1904349 [positive regulation of small intestine smooth muscle contraction]
GO:1905065 [positive regulation of vascular associated smooth muscle cell differentiation]
Show all
976 aa
109.9 kDa
Yes 2
KIT-202
ENSP00000390987
ENST00000412167
P10721 [Direct mapping]
Mast/stem cell growth factor receptor Kit
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of the breast and female genital organs
   Cancers of haematopoietic and lymphoid tissues
   Congenital disorders of metabolism
   Congenital disorders of amino acid metabolism
   Immune system diseases
   Allergies and autoimmune diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000187 [activation of MAPK activity]
GO:0001541 [ovarian follicle development]
GO:0001650 [fibrillar center]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0002327 [immature B cell differentiation]
GO:0002371 [dendritic cell cytokine production]
GO:0002551 [mast cell chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organism development]
GO:0007283 [spermatogenesis]
GO:0008360 [regulation of cell shape]
GO:0008584 [male gonad development]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019827 [stem cell population maintenance]
GO:0019955 [cytokine binding]
GO:0030032 [lamellipodium assembly]
GO:0030097 [hemopoiesis]
GO:0030183 [B cell differentiation]
GO:0030217 [T cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0030318 [melanocyte differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032762 [mast cell cytokine production]
GO:0033674 [positive regulation of kinase activity]
GO:0035162 [embryonic hemopoiesis]
GO:0035855 [megakaryocyte development]
GO:0038093 [Fc receptor signaling pathway]
GO:0038109 [Kit signaling pathway]
GO:0038162 [erythropoietin-mediated signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043303 [mast cell degranulation]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043473 [pigmentation]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0046427 [positive regulation of receptor signaling pathway via JAK-STAT]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048565 [digestive tract development]
GO:0048863 [stem cell differentiation]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060326 [cell chemotaxis]
GO:0060374 [mast cell differentiation]
GO:0070662 [mast cell proliferation]
GO:0097324 [melanocyte migration]
GO:0097326 [melanocyte adhesion]
GO:1905065 [positive regulation of vascular associated smooth muscle cell differentiation]
Show all
972 aa
109.5 kDa
Yes 2

Contact

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  • PRESS ROOM
  • contact@proteinatlas.org

The Project

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  • ORGANIZATION
  • PUBLICATIONS

The Human Protein Atlas

  • DOWNLOADABLE DATA
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.