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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:25.9 nTPM
HPA:25.9 nTPM
GTEx:10.6 nTPM
FANTOM5:82.5 Scaled Tags Per Million
Pig:18.9 nTPM
Mouse:8.4 nTPM
Allen mouse:2.3 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 25.9
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 25.7
2828 Female, age 72, unknown 39.6
2586 Male, age 75, left hemisphere 36.5
2666 Male, age 74, left hemisphere 36.0
1833 Male, age 53, unknown 31.8
2219 Male, age 76, both hemispheres 26.4
1827 Male, age 72, unknown 23.8
1830 Male, age 51, unknown 22.0
2019 Male, age 18, unknown 16.3
1870 Female, age 42, unknown 13.1
2411 Female, age 72, unknown 11.1
Dorsal raphe nucleus
nTPM: 14.4
1828 Male, age 53, unknown 20.4
2047 Male, age 72, unknown 18.1
2016 Female, age 72, unknown 15.2
2750 Male, age 76, both hemispheres 12.7
2298 Female, age 72, unknown 5.6
Inferior colliculus
nTPM: 25.0
2849 Male, age 72, unknown 49.7
1848 Female, age 42, unknown 20.3
1890 Male, age 53, unknown 19.4
2097 Female, age 72, unknown 10.7
Median raphe nucleus
nTPM: 23.7
2220 Male, age 76, midline 23.7
Pedunculopontine tegmental nucleus
nTPM: 14.9
2334 Male, age 80, both hemispheres 20.6
1921 Female, age 85, both hemispheres 13.7
2338 Male, age 61, both hemispheres 10.5
Periaquaductal grey, anterior
nTPM: 18.3
2502 Female, age 75, unknown 21.9
1795 Male, age 51, unknown 21.4
1947 Male, age 18, unknown 11.7
Periaquaductal grey, dorsal
nTPM: 25.1
2850 Male, age 76, both hemispheres 39.7
2464 Female, age 72, unknown 25.5
1840 Male, age 53, unknown 20.0
1831 Male, age 72, unknown 15.2
Periaquaductal grey, lateral
nTPM: 21.7
2140 Male, age 76, both hemispheres 32.2
2272 Male, age 74, both hemispheres 16.9
2053 Male, age 18, unknown 15.8
Pretectal area
nTPM: 24.1
1816 Male, age 51, unknown 34.2
1944 Female, age 72, unknown 32.5
1817 Female, age 42, unknown 29.4
1815 Male, age 53, unknown 29.0
2667 Female, age 75, unknown 28.3
2825 Male, age 18, unknown 27.0
2007 Male, age 72, unknown 25.6
2407 Male, age 75, both hemispheres 21.1
2316 Male, age 76, right hemisphere 15.9
2224 Female, age 72, unknown 13.7
2273 Male, age 74, both hemispheres 9.1
Red nucleus
nTPM: 25.9
2588 Male, age 74, left hemisphere 31.2
2503 Female, age 72, unknown 29.8
1904 Male, age 53, unknown 29.2
2823 Male, age 76, right hemisphere 29.0
1954 Female, age 42, unknown 28.8
2769 Male, age 72, unknown 28.5
2227 Male, age 72, unknown 26.3
1865 Male, age 51, unknown 24.2
2584 Male, age 75, left hemisphere 23.1
2725 Female, age 75, unknown 22.5
2785 Male, age 18, unknown 21.8
1821 Female, age 72, unknown 16.8
Substantia nigra
nTPM: 22.7
2699 Male, age 18, unknown 49.2
2665 Male, age 74, both hemispheres 46.5
2583 Male, age 75, right hemisphere 24.1
1916 Female, age 42, unknown 20.4
1889 Female, age 72, unknown 19.2
2590 Female, age 75, unknown 18.7
1851 Male, age 51, unknown 15.9
2409 Female, age 72, unknown 15.8
1941 Male, age 53, unknown 8.7
2241 Male, age 72, unknown 8.1
Superior colliculus
nTPM: 20.9
2664 Male, age 75, both hemispheres 36.3
2087 Female, age 72, unknown 30.2
1796 Male, age 53, unknown 21.5
2261 Male, age 18, unknown 20.2
2587 Male, age 74, left hemisphere 19.5
2668 Female, age 75, unknown 18.2
1895 Male, age 76, right hemisphere 17.2
1995 Male, age 72, unknown 16.3
1839 Male, age 51, unknown 15.2
1913 Female, age 42, unknown 14.3
Ventral tegmental area
nTPM: 15.9
2218 Male, age 76, both hemispheres 22.7
1942 Male, age 51, unknown 18.3
2021 Male, age 53, unknown 16.2
1915 Female, age 42, unknown 13.6
2410 Female, age 72, unknown 12.8
2223 Female, age 72, unknown 11.6

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 10.6
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 10.6
Samples: 139

Max nTPM: 31.4
Min nTPM: 4.4
Std nTPM: 4.1
Median nTPM: 9.8
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 31.4
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 31.0
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 22.5
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 20.1
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 19.9
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 18.8
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 17.5
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 17.3
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 16.4
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 16.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 16.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 16.0
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 15.4
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 15.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 14.7
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 14.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 14.6
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 14.6
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 14.4
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 14.0
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 13.9
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 13.9
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 13.8
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 13.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 13.7
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 13.6
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 13.6
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 13.5
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 13.5
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 13.5
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 13.3
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 12.7
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 12.6
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 12.4
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 12.4
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 12.3
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 12.3
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 12.2
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 12.1
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 12.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 12.1
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 12.0
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 11.7
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 11.6
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 11.5
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 11.4
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 11.1
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 11.1
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 11.0
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 10.9
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 10.9
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 10.8
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 10.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 10.8
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 10.7
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 10.6
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 10.5
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 10.5
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 10.4
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 10.3
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 10.3
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 10.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 10.2
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 10.0
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 10.0
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 10.0
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 9.9
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 9.9
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 9.9
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 9.8
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 9.8
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 9.8
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 9.8
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 9.7
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 9.7
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 9.5
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 9.5
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 9.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 9.5
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 9.5
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 9.5
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 9.4
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 9.4
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 9.3
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 8.9
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 8.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 8.8
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 8.7
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 8.6
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 8.6
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 8.6
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 8.5
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 8.5
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 8.5
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 8.4
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 8.4
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 8.4
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 8.3
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 8.3
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 8.3
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 8.2
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 8.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 8.1
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 8.1
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 8.0
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 7.8
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 7.7
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 7.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 7.6
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 7.5
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 7.5
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 7.3
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 7.2
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 7.1
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 7.0
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 7.0
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 6.9
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 6.8
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 6.8
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 6.8
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 6.7
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 6.6
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 6.5
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 6.5
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 6.4
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 6.3
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 6.3
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 6.2
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 6.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 6.1
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 6.1
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 6.1
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 5.9
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 5.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 5.5
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 5.0
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 4.9
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 4.9
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 4.4
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 82.5
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 82.5
FF:10158-103A5 76 years, female 82.5

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 18.9
Pig sample Sample description nTPM
Midbrain
nTPM: 18.9
Samples: 4

Max nTPM: 25.9
Min nTPM: 13.6
Sample A Female 13.6
Sample B Female 15.8
Sample C Male 25.9
Sample D Male 20.2
Periaqueductal gray
nTPM: 15.5
Samples: 3

Max nTPM: 17.1
Min nTPM: 14.1
Sample B Female 15.3
Sample C Male 17.1
Sample D Male 14.1
Substantia nigra
nTPM: 17.8
Samples: 4

Max nTPM: 22.0
Min nTPM: 14.6
Sample A Female 14.6
Sample B Female 15.8
Sample C Male 22.0
Sample D Male 18.7
Superior colliculi
nTPM: 18.4
Samples: 4

Max nTPM: 21.8
Min nTPM: 14.0
Sample A Female 16.3
Sample B Female 14.0
Sample C Male 21.4
Sample D Male 21.8

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 8.4
Mouse sample Sample description nTPM
Midbrain
nTPM: 8.5
Samples: 4

Max nTPM: 9.3
Min nTPM: 7.6
Sample A Male 8.0
Sample B Male 7.6
Sample C Female 8.9
Sample D Female 9.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 2.3
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 2.3
79591687 Antisense, RP_071204_04_H02, Mouse strain C57BL/6J (56 days, male) 3.7
79904156 Antisense, RP_071204_04_H02, Mouse strain C57BL/6J (56 days, male) 1.5
73808468 Antisense, RP_051212_03_A09, Mouse strain C57BL/6J (56 days, male) 0.8

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