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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:140.7 nTPM
HPA:140.7 nTPM
GTEx:80.4 nTPM
FANTOM5:134.1 Scaled Tags Per Million
Pig:117.0 nTPM
Mouse:25.1 nTPM
Allen mouse:0.6 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 140.7
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 98.8
2586 Male, age 75, left hemisphere 138.0
2666 Male, age 74, left hemisphere 107.2
1870 Female, age 42, unknown 104.0
1833 Male, age 53, unknown 97.0
2219 Male, age 76, both hemispheres 96.7
2828 Female, age 72, unknown 94.7
2411 Female, age 72, unknown 89.4
1830 Male, age 51, unknown 88.4
2019 Male, age 18, unknown 87.2
1827 Male, age 72, unknown 85.7
Dorsal raphe nucleus
nTPM: 114.9
2047 Male, age 72, unknown 147.3
2298 Female, age 72, unknown 115.4
2750 Male, age 76, both hemispheres 109.7
1828 Male, age 53, unknown 103.9
2016 Female, age 72, unknown 98.4
Inferior colliculus
nTPM: 99.4
1848 Female, age 42, unknown 107.5
2849 Male, age 72, unknown 105.2
1890 Male, age 53, unknown 98.1
2097 Female, age 72, unknown 86.7
Median raphe nucleus
nTPM: 140.7
2220 Male, age 76, midline 140.7
Pedunculopontine tegmental nucleus
nTPM: 93.9
1921 Female, age 85, both hemispheres 98.0
2334 Male, age 80, both hemispheres 95.8
2338 Male, age 61, both hemispheres 87.8
Periaquaductal grey, anterior
nTPM: 84.6
1795 Male, age 51, unknown 88.3
2502 Female, age 75, unknown 88.2
1947 Male, age 18, unknown 77.4
Periaquaductal grey, dorsal
nTPM: 97.8
1840 Male, age 53, unknown 112.3
2850 Male, age 76, both hemispheres 102.3
2464 Female, age 72, unknown 90.4
1831 Male, age 72, unknown 86.4
Periaquaductal grey, lateral
nTPM: 91.7
2053 Male, age 18, unknown 100.4
2140 Male, age 76, both hemispheres 95.3
2272 Male, age 74, both hemispheres 79.3
Pretectal area
nTPM: 89.6
1817 Female, age 42, unknown 100.7
2825 Male, age 18, unknown 100.7
2224 Female, age 72, unknown 96.5
2007 Male, age 72, unknown 92.6
2407 Male, age 75, both hemispheres 90.0
1815 Male, age 53, unknown 88.7
2667 Female, age 75, unknown 88.7
1944 Female, age 72, unknown 88.2
1816 Male, age 51, unknown 84.4
2316 Male, age 76, right hemisphere 80.1
2273 Male, age 74, both hemispheres 75.4
Red nucleus
nTPM: 84.9
2584 Male, age 75, left hemisphere 100.0
2588 Male, age 74, left hemisphere 96.2
2227 Male, age 72, unknown 86.7
2769 Male, age 72, unknown 86.4
2785 Male, age 18, unknown 86.4
2503 Female, age 72, unknown 84.8
1954 Female, age 42, unknown 84.0
1821 Female, age 72, unknown 83.2
1904 Male, age 53, unknown 80.2
2725 Female, age 75, unknown 79.8
1865 Male, age 51, unknown 77.4
2823 Male, age 76, right hemisphere 74.0
Substantia nigra
nTPM: 104.1
2665 Male, age 74, both hemispheres 124.8
1916 Female, age 42, unknown 117.1
2583 Male, age 75, right hemisphere 110.1
1941 Male, age 53, unknown 107.1
1851 Male, age 51, unknown 105.2
2241 Male, age 72, unknown 102.4
2699 Male, age 18, unknown 102.2
1889 Female, age 72, unknown 95.4
2590 Female, age 75, unknown 91.6
2409 Female, age 72, unknown 85.4
Superior colliculus
nTPM: 91.6
2664 Male, age 75, both hemispheres 112.9
2668 Female, age 75, unknown 103.1
1839 Male, age 51, unknown 97.2
1796 Male, age 53, unknown 91.8
1895 Male, age 76, right hemisphere 90.7
2587 Male, age 74, left hemisphere 88.2
2087 Female, age 72, unknown 87.6
2261 Male, age 18, unknown 87.6
1995 Male, age 72, unknown 81.6
1913 Female, age 42, unknown 74.9
Ventral tegmental area
nTPM: 107.8
1942 Male, age 51, unknown 122.5
1915 Female, age 42, unknown 118.0
2223 Female, age 72, unknown 106.9
2218 Male, age 76, both hemispheres 104.0
2021 Male, age 53, unknown 101.6
2410 Female, age 72, unknown 94.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 80.4
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 80.4
Samples: 139

Max nTPM: 166.0
Min nTPM: 19.5
Std nTPM: 24.6
Median nTPM: 79.6
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 166.0
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 133.5
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 125.4
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 122.1
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 119.6
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 119.3
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 118.4
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 116.7
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 116.5
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 114.9
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 113.8
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 113.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 112.7
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 110.9
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 110.7
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 110.0
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 109.8
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 108.6
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 107.7
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 106.7
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 105.3
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 105.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 105.1
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 105.0
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 104.8
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 104.5
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 103.7
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 103.5
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 103.5
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 102.5
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 102.4
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 102.3
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 101.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 101.7
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 101.1
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 100.9
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 99.0
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 97.7
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 97.6
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 95.8
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 93.8
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 93.6
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 93.6
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 93.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 93.4
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 92.7
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 92.5
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 90.6
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 88.1
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 86.9
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 85.8
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 85.8
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 85.6
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 85.6
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 85.4
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 84.8
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 84.7
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 84.7
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 84.3
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 83.7
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 83.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 82.2
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 82.2
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 81.7
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 81.7
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 81.6
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 80.8
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 80.4
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 80.2
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 79.6
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 79.4
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 78.8
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 78.6
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 78.4
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 77.2
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 76.7
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 76.5
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 76.4
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 76.4
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 76.0
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 74.8
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 74.3
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 74.3
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 73.3
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 73.1
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 72.7
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 72.5
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 72.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 72.1
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 71.9
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 71.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 71.4
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 71.4
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 71.4
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 70.3
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 69.7
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 69.6
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 68.1
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 67.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 67.9
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 67.2
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 66.5
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 64.9
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 64.6
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 64.1
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 63.6
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 62.9
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 62.2
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 61.7
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 61.5
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 61.1
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 60.5
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 60.2
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 59.8
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 59.1
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 58.6
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 57.4
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 55.7
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 51.8
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 51.4
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 50.6
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 50.6
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 50.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 49.0
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 48.4
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 47.5
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 45.5
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 45.3
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 44.0
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 42.7
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 41.1
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 40.2
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 37.4
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 36.8
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 36.8
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 33.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 29.0
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 19.8
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 19.5
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 134.1
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 134.1
FF:10158-103A5 76 years, female 134.1

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 117.0
Pig sample Sample description nTPM
Midbrain
nTPM: 81.1
Samples: 4

Max nTPM: 127.1
Min nTPM: 54.7
Sample A Female 127.1
Sample B Female 61.9
Sample C Male 80.6
Sample D Male 54.7
Periaqueductal gray
nTPM: 55.1
Samples: 3

Max nTPM: 68.0
Min nTPM: 47.7
Sample B Female 49.5
Sample C Male 68.0
Sample D Male 47.7
Substantia nigra
nTPM: 92.2
Samples: 4

Max nTPM: 135.7
Min nTPM: 67.4
Sample A Female 90.6
Sample B Female 135.7
Sample C Male 67.4
Sample D Male 75.1
Superior colliculi
nTPM: 117.1
Samples: 4

Max nTPM: 228.6
Min nTPM: 50.0
Sample A Female 133.1
Sample B Female 228.6
Sample C Male 50.0
Sample D Male 56.5

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 25.1
Mouse sample Sample description nTPM
Midbrain
nTPM: 25.1
Samples: 4

Max nTPM: 28.2
Min nTPM: 22.4
Sample A Male 28.2
Sample B Male 22.4
Sample C Female 24.2
Sample D Female 25.7

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.6
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.6
69782061 Antisense, RP_050505_02_C04, Mouse strain C57BL/6J (56 days, male) 0.6

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