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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:41.8 nTPM
HPA:41.8 nTPM
GTEx:46.4 nTPM
FANTOM5:26.2 Scaled Tags Per Million
Pig:75.0 nTPM
Mouse:104.9 nTPM
Allen mouse:3.2 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 41.8
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 41.8
2586 Male, age 75, left hemisphere 68.6
2019 Male, age 18, unknown 55.8
2828 Female, age 72, unknown 50.2
2666 Male, age 74, left hemisphere 41.0
1870 Female, age 42, unknown 36.0
1827 Male, age 72, unknown 35.3
1833 Male, age 53, unknown 35.1
1830 Male, age 51, unknown 34.7
2411 Female, age 72, unknown 33.2
2219 Male, age 76, both hemispheres 28.1
Dorsal raphe nucleus
nTPM: 34.0
2016 Female, age 72, unknown 39.6
1828 Male, age 53, unknown 38.4
2047 Male, age 72, unknown 34.6
2298 Female, age 72, unknown 31.1
2750 Male, age 76, both hemispheres 26.5
Inferior colliculus
nTPM: 36.0
1890 Male, age 53, unknown 39.3
1848 Female, age 42, unknown 38.5
2097 Female, age 72, unknown 33.8
2849 Male, age 72, unknown 32.4
Median raphe nucleus
nTPM: 20.7
2220 Male, age 76, midline 20.7
Pedunculopontine tegmental nucleus
nTPM: 27.1
1921 Female, age 85, both hemispheres 29.4
2334 Male, age 80, both hemispheres 29.2
2338 Male, age 61, both hemispheres 22.6
Periaquaductal grey, anterior
nTPM: 36.7
2502 Female, age 75, unknown 39.1
1795 Male, age 51, unknown 36.1
1947 Male, age 18, unknown 34.9
Periaquaductal grey, dorsal
nTPM: 31.3
1831 Male, age 72, unknown 33.5
1840 Male, age 53, unknown 33.2
2464 Female, age 72, unknown 32.0
2850 Male, age 76, both hemispheres 26.4
Periaquaductal grey, lateral
nTPM: 29.5
2053 Male, age 18, unknown 31.5
2272 Male, age 74, both hemispheres 30.1
2140 Male, age 76, both hemispheres 26.9
Pretectal area
nTPM: 37.4
2407 Male, age 75, both hemispheres 48.0
1817 Female, age 42, unknown 46.4
2007 Male, age 72, unknown 42.1
1815 Male, age 53, unknown 39.7
1816 Male, age 51, unknown 39.7
1944 Female, age 72, unknown 38.1
2273 Male, age 74, both hemispheres 37.0
2667 Female, age 75, unknown 34.9
2316 Male, age 76, right hemisphere 28.8
2825 Male, age 18, unknown 28.4
2224 Female, age 72, unknown 28.0
Red nucleus
nTPM: 37.9
2785 Male, age 18, unknown 45.9
2584 Male, age 75, left hemisphere 42.7
2588 Male, age 74, left hemisphere 42.6
2769 Male, age 72, unknown 38.5
1954 Female, age 42, unknown 37.7
2227 Male, age 72, unknown 37.7
2503 Female, age 72, unknown 36.8
1865 Male, age 51, unknown 36.7
1821 Female, age 72, unknown 35.4
1904 Male, age 53, unknown 34.7
2823 Male, age 76, right hemisphere 33.8
2725 Female, age 75, unknown 32.7
Substantia nigra
nTPM: 36.9
2583 Male, age 75, right hemisphere 48.8
2590 Female, age 75, unknown 42.1
2665 Male, age 74, both hemispheres 40.4
1851 Male, age 51, unknown 37.8
1916 Female, age 42, unknown 36.7
1889 Female, age 72, unknown 35.3
1941 Male, age 53, unknown 35.3
2699 Male, age 18, unknown 31.3
2409 Female, age 72, unknown 30.9
2241 Male, age 72, unknown 30.4
Superior colliculus
nTPM: 39.7
2664 Male, age 75, both hemispheres 64.4
1995 Male, age 72, unknown 46.4
1913 Female, age 42, unknown 39.0
2668 Female, age 75, unknown 38.8
2087 Female, age 72, unknown 38.2
1839 Male, age 51, unknown 36.7
1796 Male, age 53, unknown 34.2
2587 Male, age 74, left hemisphere 33.9
2261 Male, age 18, unknown 33.8
1895 Male, age 76, right hemisphere 31.9
Ventral tegmental area
nTPM: 34.2
1942 Male, age 51, unknown 39.9
2410 Female, age 72, unknown 36.1
2021 Male, age 53, unknown 35.6
1915 Female, age 42, unknown 33.6
2223 Female, age 72, unknown 32.8
2218 Male, age 76, both hemispheres 27.4

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 46.4
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 46.4
Samples: 139

Max nTPM: 96.1
Min nTPM: 22.9
Std nTPM: 12.7
Median nTPM: 43.0
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 96.1
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 83.3
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 82.1
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 79.9
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 75.3
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 73.5
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 72.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 69.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 68.6
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 68.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 68.2
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 66.7
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 66.4
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 64.7
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 63.4
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 62.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 61.8
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 61.7
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 61.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 61.0
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 60.4
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 60.0
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 59.9
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 59.8
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 58.9
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 58.3
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 57.2
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 56.9
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 56.5
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 55.3
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 55.0
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 54.8
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 54.0
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 53.6
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 52.3
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 51.0
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 50.3
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 50.2
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 50.2
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 50.2
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 50.0
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 49.9
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 49.8
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 49.5
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 49.4
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 48.5
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 48.1
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 48.0
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 47.8
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 47.6
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 47.6
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 47.3
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 47.3
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 47.1
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 46.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 46.1
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 46.1
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 46.0
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 45.0
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 44.7
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 44.3
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 44.2
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 43.8
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 43.8
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 43.8
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 43.5
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 43.4
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 43.4
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 43.1
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 43.0
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 42.9
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 42.9
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 42.6
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 42.5
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 42.4
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 42.2
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 42.0
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 41.9
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 41.2
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 41.1
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 40.9
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 40.7
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 40.6
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 40.5
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 40.3
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 40.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 40.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 40.1
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 39.9
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 39.3
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 39.2
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 39.1
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 39.0
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 38.9
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 38.7
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 38.6
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 38.6
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 38.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 38.4
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 38.4
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 38.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 38.1
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 37.9
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 37.8
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 37.8
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 37.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 37.3
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 37.0
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 36.7
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 36.6
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 36.4
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 36.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 36.1
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 36.0
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 35.8
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 35.6
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 35.4
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 35.2
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 35.2
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 34.9
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 34.8
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 34.5
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 34.3
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 34.2
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 33.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 33.8
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 33.7
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 33.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 33.0
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 33.0
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 32.6
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 31.8
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 30.8
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 30.8
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 30.3
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 29.3
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 28.5
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 26.0
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 22.9
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 26.2
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 26.2
FF:10158-103A5 76 years, female 26.2

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 75.0
Pig sample Sample description nTPM
Midbrain
nTPM: 75.0
Samples: 4

Max nTPM: 88.4
Min nTPM: 58.9
Sample A Female 79.0
Sample B Female 58.9
Sample C Male 88.4
Sample D Male 73.5
Periaqueductal gray
nTPM: 60.7
Samples: 3

Max nTPM: 63.5
Min nTPM: 56.4
Sample B Female 62.2
Sample C Male 63.5
Sample D Male 56.4
Substantia nigra
nTPM: 62.9
Samples: 4

Max nTPM: 74.2
Min nTPM: 51.2
Sample A Female 74.2
Sample B Female 51.2
Sample C Male 61.1
Sample D Male 65.1
Superior colliculi
nTPM: 71.6
Samples: 4

Max nTPM: 83.3
Min nTPM: 47.1
Sample A Female 83.3
Sample B Female 47.1
Sample C Male 76.5
Sample D Male 79.5

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 104.9
Mouse sample Sample description nTPM
Midbrain
nTPM: 104.9
Samples: 4

Max nTPM: 108.0
Min nTPM: 97.8
Sample A Male 108.0
Sample B Male 97.8
Sample C Female 107.5
Sample D Female 106.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 3.2
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 3.2
85 Antisense, RP_Baylor_103163, Mouse strain C57BL/6J (56 days, male) 3.2
86 Antisense, RP_Baylor_103163, Mouse strain C57BL/6J (56 days, male) 0.0

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