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PEA15
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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:1010.2 nTPM
HPA:1010.2 nTPM
GTEx:979.9 nTPM
FANTOM5:986.0 Scaled Tags Per Million
Pig:973.7 nTPM
Mouse:537.0 nTPM
Allen mouse:11.9 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 1010.2
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 909.5
2586 Male, age 75, left hemisphere 1015.9
2666 Male, age 74, left hemisphere 1002.5
1870 Female, age 42, unknown 966.3
2828 Female, age 72, unknown 928.4
2411 Female, age 72, unknown 905.2
1830 Male, age 51, unknown 901.2
1833 Male, age 53, unknown 898.1
1827 Male, age 72, unknown 869.4
2219 Male, age 76, both hemispheres 818.4
2019 Male, age 18, unknown 789.8
Dorsal raphe nucleus
nTPM: 925.3
2750 Male, age 76, both hemispheres 992.9
2047 Male, age 72, unknown 978.8
1828 Male, age 53, unknown 896.8
2016 Female, age 72, unknown 890.2
2298 Female, age 72, unknown 867.6
Inferior colliculus
nTPM: 822.9
2849 Male, age 72, unknown 860.1
1890 Male, age 53, unknown 831.9
1848 Female, age 42, unknown 831.8
2097 Female, age 72, unknown 767.7
Median raphe nucleus
nTPM: 1010.2
2220 Male, age 76, midline 1010.2
Pedunculopontine tegmental nucleus
nTPM: 887.5
2334 Male, age 80, both hemispheres 916.6
2338 Male, age 61, both hemispheres 903.4
1921 Female, age 85, both hemispheres 842.6
Periaquaductal grey, anterior
nTPM: 871.9
1947 Male, age 18, unknown 883.7
1795 Male, age 51, unknown 876.1
2502 Female, age 75, unknown 855.8
Periaquaductal grey, dorsal
nTPM: 867.4
2850 Male, age 76, both hemispheres 906.7
1840 Male, age 53, unknown 893.8
2464 Female, age 72, unknown 844.9
1831 Male, age 72, unknown 824.2
Periaquaductal grey, lateral
nTPM: 849.0
2053 Male, age 18, unknown 908.3
2140 Male, age 76, both hemispheres 850.2
2272 Male, age 74, both hemispheres 788.4
Pretectal area
nTPM: 822.6
2825 Male, age 18, unknown 924.3
2407 Male, age 75, both hemispheres 858.3
2667 Female, age 75, unknown 842.3
1815 Male, age 53, unknown 841.2
2224 Female, age 72, unknown 836.5
1817 Female, age 42, unknown 815.5
1816 Male, age 51, unknown 812.5
1944 Female, age 72, unknown 797.4
2316 Male, age 76, right hemisphere 778.1
2273 Male, age 74, both hemispheres 772.2
2007 Male, age 72, unknown 770.6
Red nucleus
nTPM: 925.4
2769 Male, age 72, unknown 971.6
2227 Male, age 72, unknown 957.9
1865 Male, age 51, unknown 956.6
1821 Female, age 72, unknown 956.1
1904 Male, age 53, unknown 953.8
2588 Male, age 74, left hemisphere 948.6
1954 Female, age 42, unknown 947.4
2584 Male, age 75, left hemisphere 937.3
2725 Female, age 75, unknown 911.5
2503 Female, age 72, unknown 894.7
2823 Male, age 76, right hemisphere 881.9
2785 Male, age 18, unknown 787.8
Substantia nigra
nTPM: 914.6
2699 Male, age 18, unknown 1044.2
1916 Female, age 42, unknown 982.0
2583 Male, age 75, right hemisphere 958.4
1851 Male, age 51, unknown 940.6
2665 Male, age 74, both hemispheres 919.9
2241 Male, age 72, unknown 903.4
2590 Female, age 75, unknown 863.9
1889 Female, age 72, unknown 856.8
1941 Male, age 53, unknown 846.7
2409 Female, age 72, unknown 830.5
Superior colliculus
nTPM: 847.2
2664 Male, age 75, both hemispheres 933.0
2587 Male, age 74, left hemisphere 884.7
2668 Female, age 75, unknown 883.4
1913 Female, age 42, unknown 860.0
1796 Male, age 53, unknown 848.9
1839 Male, age 51, unknown 835.4
1995 Male, age 72, unknown 831.8
2261 Male, age 18, unknown 831.2
2087 Female, age 72, unknown 792.4
1895 Male, age 76, right hemisphere 770.7
Ventral tegmental area
nTPM: 960.2
2223 Female, age 72, unknown 1176.5
2021 Male, age 53, unknown 935.7
1915 Female, age 42, unknown 921.9
2410 Female, age 72, unknown 920.9
2218 Male, age 76, both hemispheres 905.1
1942 Male, age 51, unknown 901.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 979.9
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 979.9
Samples: 139

Max nTPM: 1957.9
Min nTPM: 264.8
Std nTPM: 283.6
Median nTPM: 935.0
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 1957.9
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 1754.6
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 1699.0
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 1665.8
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 1648.6
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 1589.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 1570.2
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 1528.7
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 1498.5
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 1467.2
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 1460.6
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 1459.0
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 1423.3
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 1401.7
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 1401.0
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 1381.5
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 1355.4
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 1328.5
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 1305.5
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 1261.2
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 1259.7
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 1237.9
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 1229.5
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 1218.3
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 1213.8
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 1211.9
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 1211.4
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 1179.6
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 1173.9
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 1168.2
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 1166.1
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 1150.2
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 1119.3
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 1118.2
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 1110.3
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 1095.5
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 1086.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 1082.8
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 1079.3
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 1077.1
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 1074.2
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 1072.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 1069.9
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 1068.6
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 1064.1
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 1056.1
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 1048.4
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 1047.7
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 1035.4
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 1033.2
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 1028.5
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 1011.5
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 1002.8
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 999.1
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 988.0
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 986.5
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 982.4
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 982.4
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 980.2
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 966.3
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 961.2
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 956.2
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 954.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 946.2
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 943.8
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 941.5
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 939.7
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 938.4
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 935.5
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 935.0
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 927.9
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 922.4
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 921.8
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 916.4
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 915.5
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 895.1
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 889.8
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 887.5
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 883.1
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 874.7
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 872.8
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 871.4
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 870.9
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 866.0
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 862.0
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 860.5
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 849.2
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 846.8
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 846.7
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 839.6
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 838.0
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 832.7
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 831.3
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 829.0
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 824.3
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 822.1
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 817.5
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 816.7
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 815.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 811.4
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 811.0
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 807.9
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 805.7
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 804.0
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 801.8
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 799.0
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 787.5
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 786.9
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 782.8
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 780.3
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 780.2
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 775.9
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 770.4
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 767.3
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 758.0
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 756.8
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 756.7
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 756.5
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 750.4
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 749.1
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 743.2
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 736.2
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 733.2
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 720.8
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 720.2
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 715.1
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 665.6
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 655.5
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 649.4
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 631.5
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 614.4
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 567.8
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 567.4
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 547.5
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 539.3
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 522.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 442.9
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 429.2
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 264.8
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 986.0
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 986.0
FF:10158-103A5 76 years, female 986.0

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 973.7
Pig sample Sample description nTPM
Midbrain
nTPM: 973.7
Samples: 4

Max nTPM: 2250.6
Min nTPM: 433.7
Sample A Female 2250.6
Sample B Female 761.0
Sample C Male 449.6
Sample D Male 433.7
Periaqueductal gray
nTPM: 498.3
Samples: 3

Max nTPM: 561.1
Min nTPM: 462.7
Sample B Female 561.1
Sample C Male 462.7
Sample D Male 471.0
Substantia nigra
nTPM: 826.4
Samples: 4

Max nTPM: 1007.9
Min nTPM: 541.4
Sample A Female 982.9
Sample B Female 541.4
Sample C Male 773.5
Sample D Male 1007.9
Superior colliculi
nTPM: 586.0
Samples: 4

Max nTPM: 707.3
Min nTPM: 346.8
Sample A Female 707.3
Sample B Female 346.8
Sample C Male 610.4
Sample D Male 679.5

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 537.0
Mouse sample Sample description nTPM
Midbrain
nTPM: 537.0
Samples: 4

Max nTPM: 555.2
Min nTPM: 518.9
Sample A Male 546.6
Sample B Male 518.9
Sample C Female 527.1
Sample D Female 555.2

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 11.9
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 11.9
68193012 Antisense, RP_040928_01_B12, Mouse strain C57BL/6J (56 days, male) 17.1
70928292 Antisense, RP_050725_02_C07, Mouse strain C57BL/6J (56 days, male) 11.0
77414654 Antisense, RP_070205_01_H12, Mouse strain C57BL/6J (56 days, male) 7.7

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The Human Protein Atlas

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.