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  • TERT
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

TERT
Synonyms EST2, hEST2, TCS1, TP2, TRT
Gene descriptioni

Full gene name according to HGNC.

Telomerase reverse transcriptase
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Disease related genes
Enzymes
Human disease related genes
Potential drug targets
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 5
Cytoband p15.33
Chromosome location (bp) 1253147 - 1295068
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

2
Ensembl ENSG00000164362 (version 103.38)
Entrez gene 7015
HGNC HGNC:11730
UniProt O14746 (UniProt - Evidence at protein level)
neXtProt NX_O14746
Antibodypedia TERT antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 42      # Population variants: 529

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

Off
On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
TERT-201
TERT-202


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
TERT-201
ENSP00000309572
ENST00000310581
O14746 [Direct mapping]
Telomerase reverse transcriptase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Potential drug targets
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of eye, brain, and central nervous system
   Cardiovascular diseases
   Hematologic diseases
   Other congenital disorders
   Chromosomal abnormalities
   Ribosomopathies
   Respiratory diseases
   Lung diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000333 [telomerase catalytic core complex]
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0000783 [nuclear telomere cap complex]
GO:0001172 [transcription, RNA-templated]
GO:0001223 [transcription coactivator binding]
GO:0003677 [DNA binding]
GO:0003720 [telomerase activity]
GO:0003721 [telomerase RNA reverse transcriptase activity]
GO:0003723 [RNA binding]
GO:0003964 [RNA-directed DNA polymerase activity]
GO:0003968 [RNA-directed 5'-3' RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005697 [telomerase holoenzyme complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006278 [RNA-dependent DNA biosynthetic process]
GO:0007004 [telomere maintenance via telomerase]
GO:0007005 [mitochondrion organization]
GO:0008022 [protein C-terminus binding]
GO:0010629 [negative regulation of gene expression]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0022616 [DNA strand elongation]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031379 [RNA-directed RNA polymerase complex]
GO:0031647 [regulation of protein stability]
GO:0032092 [positive regulation of protein binding]
GO:0042162 [telomeric DNA binding]
GO:0042635 [positive regulation of hair cycle]
GO:0042645 [mitochondrial nucleoid]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0046326 [positive regulation of glucose import]
GO:0046686 [response to cadmium ion]
GO:0046872 [metal ion binding]
GO:0047485 [protein N-terminus binding]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051087 [chaperone binding]
GO:0062103 [double-stranded RNA biosynthetic process]
GO:0070034 [telomerase RNA binding]
GO:0070200 [establishment of protein localization to telomere]
GO:0071456 [cellular response to hypoxia]
GO:0071897 [DNA biosynthetic process]
GO:0090399 [replicative senescence]
GO:0098680 [template-free RNA nucleotidyltransferase]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II]
GO:1903620 [positive regulation of transdifferentiation]
GO:1903704 [negative regulation of production of siRNA involved in RNA interference]
GO:1903799 [negative regulation of production of miRNAs involved in gene silencing by miRNA]
GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation]
GO:1904751 [positive regulation of protein localization to nucleolus]
GO:1904754 [positive regulation of vascular associated smooth muscle cell migration]
GO:1904837 [beta-catenin-TCF complex assembly]
GO:1990572 [TERT-RMRP complex]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
GO:2000648 [positive regulation of stem cell proliferation]
GO:2000773 [negative regulation of cellular senescence]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
1132 aa
127 kDa
No 2
TERT-202
ENSP00000334346
ENST00000334602
O14746 [Direct mapping]
Telomerase reverse transcriptase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Potential drug targets
Human disease related genes
   Cancers
   Cancers of the digestive system
   Cancers of eye, brain, and central nervous system
   Cardiovascular diseases
   Hematologic diseases
   Other congenital disorders
   Chromosomal abnormalities
   Ribosomopathies
   Respiratory diseases
   Lung diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000333 [telomerase catalytic core complex]
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0000783 [nuclear telomere cap complex]
GO:0001172 [transcription, RNA-templated]
GO:0001223 [transcription coactivator binding]
GO:0003677 [DNA binding]
GO:0003720 [telomerase activity]
GO:0003721 [telomerase RNA reverse transcriptase activity]
GO:0003723 [RNA binding]
GO:0003964 [RNA-directed DNA polymerase activity]
GO:0003968 [RNA-directed 5'-3' RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005697 [telomerase holoenzyme complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006278 [RNA-dependent DNA biosynthetic process]
GO:0007004 [telomere maintenance via telomerase]
GO:0007005 [mitochondrion organization]
GO:0008022 [protein C-terminus binding]
GO:0010629 [negative regulation of gene expression]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0022616 [DNA strand elongation]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031379 [RNA-directed RNA polymerase complex]
GO:0031647 [regulation of protein stability]
GO:0032092 [positive regulation of protein binding]
GO:0042162 [telomeric DNA binding]
GO:0042635 [positive regulation of hair cycle]
GO:0042645 [mitochondrial nucleoid]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0046872 [metal ion binding]
GO:0047485 [protein N-terminus binding]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051087 [chaperone binding]
GO:0062103 [double-stranded RNA biosynthetic process]
GO:0070034 [telomerase RNA binding]
GO:0070200 [establishment of protein localization to telomere]
GO:0071456 [cellular response to hypoxia]
GO:0071897 [DNA biosynthetic process]
GO:0090399 [replicative senescence]
GO:0098680 [template-free RNA nucleotidyltransferase]
GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II]
GO:1903704 [negative regulation of production of siRNA involved in RNA interference]
GO:1903799 [negative regulation of production of miRNAs involved in gene silencing by miRNA]
GO:1904751 [positive regulation of protein localization to nucleolus]
GO:1904837 [beta-catenin-TCF complex assembly]
GO:1990572 [TERT-RMRP complex]
GO:2000648 [positive regulation of stem cell proliferation]
GO:2000773 [negative regulation of cellular senescence]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
1069 aa
120 kDa
No 2

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.