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CITED2
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  • CITED2
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

CITED2
Synonyms MRG1
Gene descriptioni

Full gene name according to HGNC.

Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Disease related genes
Human disease related genes
Plasma proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 6
Cytoband q24.1
Chromosome location (bp) 139371807 - 139374648
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

4
Ensembl ENSG00000164442 (version 103.38)
Entrez gene 10370
HGNC HGNC:1987
UniProt Q99967 (UniProt - Evidence at protein level)
neXtProt NX_Q99967
Antibodypedia CITED2 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 0

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
CITED2-201
CITED2-202
CITED2-203
CITED2-204


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
CITED2-201
ENSP00000356623
ENST00000367651
Q99967 [Direct mapping]
Cbp/p300-interacting transactivator 2
D9ZGF1 [Target identity:100%; Query identity:100%]
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, isoform CRA_d
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Cardiovascular diseases
   Cardiac diseases
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001889 [liver development]
GO:0003151 [outflow tract morphogenesis]
GO:0003156 [regulation of animal organ formation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organism development]
GO:0007368 [determination of left/right symmetry]
GO:0007507 [heart development]
GO:0007530 [sex determination]
GO:0008283 [cell population proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0019904 [protein domain specific binding]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030154 [cell differentiation]
GO:0030336 [negative regulation of cell migration]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032991 [protein-containing complex]
GO:0034405 [response to fluid shear stress]
GO:0035035 [histone acetyltransferase binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0035802 [adrenal cortex formation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043627 [response to estrogen]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048536 [spleen development]
GO:0050693 [LBD domain binding]
GO:0060412 [ventricular septum morphogenesis]
GO:0060971 [embryonic heart tube left/right pattern formation]
GO:0060972 [left/right pattern formation]
GO:0061428 [negative regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070986 [left/right axis specification]
GO:1900164 [nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry]
GO:2000020 [positive regulation of male gonad development]
Show all
270 aa
28.5 kDa
No 0
CITED2-202
ENSP00000442831
ENST00000536159
Q99967 [Direct mapping]
Cbp/p300-interacting transactivator 2
D9ZGF1 [Target identity:100%; Query identity:100%]
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, isoform CRA_d
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Cardiovascular diseases
   Cardiac diseases
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001889 [liver development]
GO:0003151 [outflow tract morphogenesis]
GO:0003156 [regulation of animal organ formation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organism development]
GO:0007368 [determination of left/right symmetry]
GO:0007507 [heart development]
GO:0007530 [sex determination]
GO:0008283 [cell population proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0019904 [protein domain specific binding]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030154 [cell differentiation]
GO:0030336 [negative regulation of cell migration]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032991 [protein-containing complex]
GO:0034405 [response to fluid shear stress]
GO:0035035 [histone acetyltransferase binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0035802 [adrenal cortex formation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043627 [response to estrogen]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048536 [spleen development]
GO:0050693 [LBD domain binding]
GO:0060412 [ventricular septum morphogenesis]
GO:0060971 [embryonic heart tube left/right pattern formation]
GO:0060972 [left/right pattern formation]
GO:0061428 [negative regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070986 [left/right axis specification]
GO:1900164 [nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry]
GO:2000020 [positive regulation of male gonad development]
Show all
270 aa
28.5 kDa
No 0
CITED2-203
ENSP00000444198
ENST00000537332
A0A0A0MTM3 [Direct mapping]
Cbp/p300-interacting transactivator 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Cardiovascular diseases
   Cardiac diseases
   Congenital malformations
   Congenital malformations of the circulatory system
Show all
GO:0000785 [chromatin]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001568 [blood vessel development]
GO:0001570 [vasculogenesis]
GO:0001701 [in utero embryonic development]
GO:0001829 [trophectodermal cell differentiation]
GO:0001841 [neural tube formation]
GO:0001843 [neural tube closure]
GO:0001889 [liver development]
GO:0001892 [embryonic placenta development]
GO:0001944 [vasculature development]
GO:0001947 [heart looping]
GO:0002089 [lens morphogenesis in camera-type eye]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0002521 [leukocyte differentiation]
GO:0003151 [outflow tract morphogenesis]
GO:0003156 [regulation of animal organ formation]
GO:0003197 [endocardial cushion development]
GO:0003281 [ventricular septum development]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007368 [determination of left/right symmetry]
GO:0007417 [central nervous system development]
GO:0007422 [peripheral nervous system development]
GO:0007507 [heart development]
GO:0007530 [sex determination]
GO:0007569 [cell aging]
GO:0008584 [male gonad development]
GO:0009612 [response to mechanical stimulus]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0021602 [cranial nerve morphogenesis]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030325 [adrenal gland development]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030851 [granulocyte differentiation]
GO:0035802 [adrenal cortex formation]
GO:0035914 [skeletal muscle cell differentiation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045787 [positive regulation of cell cycle]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0046697 [decidualization]
GO:0048536 [spleen development]
GO:0048538 [thymus development]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0048821 [erythrocyte development]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0060136 [embryonic process involved in female pregnancy]
GO:0060349 [bone morphogenesis]
GO:0060411 [cardiac septum morphogenesis]
GO:0060412 [ventricular septum morphogenesis]
GO:0060971 [embryonic heart tube left/right pattern formation]
GO:0061156 [pulmonary artery morphogenesis]
GO:0061308 [cardiac neural crest cell development involved in heart development]
GO:0061371 [determination of heart left/right asymmetry]
GO:0070986 [left/right axis specification]
GO:0071363 [cellular response to growth factor stimulus]
GO:1900164 [nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry]
GO:2000020 [positive regulation of male gonad development]
Show all
275 aa
29 kDa
No 0
CITED2-204
ENSP00000479918
ENST00000618718
Q99967 [Direct mapping]
Cbp/p300-interacting transactivator 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Cardiovascular diseases
   Cardiac diseases
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001889 [liver development]
GO:0003151 [outflow tract morphogenesis]
GO:0003156 [regulation of animal organ formation]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organism development]
GO:0007368 [determination of left/right symmetry]
GO:0007507 [heart development]
GO:0007530 [sex determination]
GO:0008283 [cell population proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0019904 [protein domain specific binding]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030154 [cell differentiation]
GO:0030336 [negative regulation of cell migration]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032991 [protein-containing complex]
GO:0034405 [response to fluid shear stress]
GO:0035035 [histone acetyltransferase binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0035802 [adrenal cortex formation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043627 [response to estrogen]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048536 [spleen development]
GO:0050693 [LBD domain binding]
GO:0060412 [ventricular septum morphogenesis]
GO:0060971 [embryonic heart tube left/right pattern formation]
GO:0060972 [left/right pattern formation]
GO:0061428 [negative regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070986 [left/right axis specification]
GO:1900164 [nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry]
GO:2000020 [positive regulation of male gonad development]
Show all
213 aa
23.7 kDa
No 0

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