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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Enzymes FDA approved drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q22.2
Chromosome location (bp)
90801787 - 90898549
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
SYK-201
SYK-202
SYK-203
SYK-204
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0000187 [activation of MAPK activity] GO:0001525 [angiogenesis] GO:0001784 [phosphotyrosine residue binding] GO:0001819 [positive regulation of cytokine production] GO:0001820 [serotonin secretion] GO:0001945 [lymph vessel development] GO:0002092 [positive regulation of receptor internalization] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002281 [macrophage activation involved in immune response] GO:0002283 [neutrophil activation involved in immune response] GO:0002366 [leukocyte activation involved in immune response] GO:0002376 [immune system process] GO:0002554 [serotonin secretion by platelet] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [signaling receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006606 [protein import into nucleus] GO:0007159 [leukocyte cell-cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007167 [enzyme linked receptor protein signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007257 [activation of JUN kinase activity] GO:0009887 [animal organ morphogenesis] GO:0010543 [regulation of platelet activation] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016170 [interleukin-15 receptor binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019370 [leukotriene biosynthetic process] GO:0019815 [B cell receptor complex] GO:0019901 [protein kinase binding] GO:0019902 [phosphatase binding] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030593 [neutrophil chemotaxis] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031623 [receptor internalization] GO:0032009 [early phagosome] GO:0032481 [positive regulation of type I interferon production] GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0032733 [positive regulation of interleukin-10 production] GO:0032735 [positive regulation of interleukin-12 production] GO:0032752 [positive regulation of interleukin-3 production] GO:0032753 [positive regulation of interleukin-4 production] GO:0032755 [positive regulation of interleukin-6 production] GO:0032757 [positive regulation of interleukin-8 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0032928 [regulation of superoxide anion generation] GO:0032930 [positive regulation of superoxide anion generation] GO:0032991 [protein-containing complex] GO:0033630 [positive regulation of cell adhesion mediated by integrin] GO:0035325 [Toll-like receptor binding] GO:0035556 [intracellular signal transduction] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0038110 [interleukin-2-mediated signaling pathway] GO:0038156 [interleukin-3-mediated signaling pathway] GO:0042101 [T cell receptor complex] GO:0042127 [regulation of cell population proliferation] GO:0042169 [SH2 domain binding] GO:0042742 [defense response to bacterium] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043306 [positive regulation of mast cell degranulation] GO:0043313 [regulation of neutrophil degranulation] GO:0043366 [beta selection] GO:0045087 [innate immune response] GO:0045579 [positive regulation of B cell differentiation] GO:0045588 [positive regulation of gamma-delta T cell differentiation] GO:0045780 [positive regulation of bone resorption] GO:0046638 [positive regulation of alpha-beta T cell differentiation] GO:0046641 [positive regulation of alpha-beta T cell proliferation] GO:0046777 [protein autophosphorylation] GO:0048514 [blood vessel morphogenesis] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050764 [regulation of phagocytosis] GO:0050850 [positive regulation of calcium-mediated signaling] GO:0050853 [B cell receptor signaling pathway] GO:0051090 [regulation of DNA-binding transcription factor activity] GO:0051712 [positive regulation of killing of cells of other organism] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0071226 [cellular response to molecule of fungal origin] GO:0071404 [cellular response to low-density lipoprotein particle stimulus] GO:0071639 [positive regulation of monocyte chemotactic protein-1 production] GO:0090237 [regulation of arachidonic acid secretion] GO:0090330 [regulation of platelet aggregation] GO:0120162 [positive regulation of cold-induced thermogenesis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0001525 [angiogenesis] GO:0001784 [phosphotyrosine residue binding] GO:0001945 [lymph vessel development] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002281 [macrophage activation involved in immune response] GO:0002283 [neutrophil activation involved in immune response] GO:0002366 [leukocyte activation involved in immune response] GO:0002376 [immune system process] GO:0002554 [serotonin secretion by platelet] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [signaling receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006606 [protein import into nucleus] GO:0007159 [leukocyte cell-cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0009887 [animal organ morphogenesis] GO:0010543 [regulation of platelet activation] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016170 [interleukin-15 receptor binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030593 [neutrophil chemotaxis] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031623 [receptor internalization] GO:0032009 [early phagosome] GO:0032733 [positive regulation of interleukin-10 production] GO:0032735 [positive regulation of interleukin-12 production] GO:0032753 [positive regulation of interleukin-4 production] GO:0032755 [positive regulation of interleukin-6 production] GO:0032757 [positive regulation of interleukin-8 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0032928 [regulation of superoxide anion generation] GO:0032930 [positive regulation of superoxide anion generation] GO:0032991 [protein-containing complex] GO:0033630 [positive regulation of cell adhesion mediated by integrin] GO:0035556 [intracellular signal transduction] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0038110 [interleukin-2-mediated signaling pathway] GO:0038156 [interleukin-3-mediated signaling pathway] GO:0042101 [T cell receptor complex] GO:0042127 [regulation of cell population proliferation] GO:0042742 [defense response to bacterium] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043306 [positive regulation of mast cell degranulation] GO:0043313 [regulation of neutrophil degranulation] GO:0045087 [innate immune response] GO:0045579 [positive regulation of B cell differentiation] GO:0045780 [positive regulation of bone resorption] GO:0046641 [positive regulation of alpha-beta T cell proliferation] GO:0048514 [blood vessel morphogenesis] GO:0050764 [regulation of phagocytosis] GO:0050853 [B cell receptor signaling pathway] GO:0051090 [regulation of DNA-binding transcription factor activity] GO:0051712 [positive regulation of killing of cells of other organism] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0071226 [cellular response to molecule of fungal origin] GO:0071404 [cellular response to low-density lipoprotein particle stimulus] GO:0071639 [positive regulation of monocyte chemotactic protein-1 production] GO:0090237 [regulation of arachidonic acid secretion] GO:0090330 [regulation of platelet aggregation] GO:0120162 [positive regulation of cold-induced thermogenesis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0001525 [angiogenesis] GO:0001784 [phosphotyrosine residue binding] GO:0001945 [lymph vessel development] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002281 [macrophage activation involved in immune response] GO:0002283 [neutrophil activation involved in immune response] GO:0002366 [leukocyte activation involved in immune response] GO:0002376 [immune system process] GO:0002554 [serotonin secretion by platelet] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [signaling receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006606 [protein import into nucleus] GO:0007159 [leukocyte cell-cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0009887 [animal organ morphogenesis] GO:0010543 [regulation of platelet activation] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016170 [interleukin-15 receptor binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030593 [neutrophil chemotaxis] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031623 [receptor internalization] GO:0032009 [early phagosome] GO:0032733 [positive regulation of interleukin-10 production] GO:0032735 [positive regulation of interleukin-12 production] GO:0032753 [positive regulation of interleukin-4 production] GO:0032755 [positive regulation of interleukin-6 production] GO:0032757 [positive regulation of interleukin-8 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0032928 [regulation of superoxide anion generation] GO:0032930 [positive regulation of superoxide anion generation] GO:0032991 [protein-containing complex] GO:0033630 [positive regulation of cell adhesion mediated by integrin] GO:0035556 [intracellular signal transduction] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0038110 [interleukin-2-mediated signaling pathway] GO:0038156 [interleukin-3-mediated signaling pathway] GO:0042101 [T cell receptor complex] GO:0042127 [regulation of cell population proliferation] GO:0042742 [defense response to bacterium] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043306 [positive regulation of mast cell degranulation] GO:0043313 [regulation of neutrophil degranulation] GO:0045087 [innate immune response] GO:0045579 [positive regulation of B cell differentiation] GO:0045780 [positive regulation of bone resorption] GO:0046641 [positive regulation of alpha-beta T cell proliferation] GO:0048514 [blood vessel morphogenesis] GO:0050764 [regulation of phagocytosis] GO:0050853 [B cell receptor signaling pathway] GO:0051090 [regulation of DNA-binding transcription factor activity] GO:0051712 [positive regulation of killing of cells of other organism] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0071226 [cellular response to molecule of fungal origin] GO:0071404 [cellular response to low-density lipoprotein particle stimulus] GO:0071639 [positive regulation of monocyte chemotactic protein-1 production] GO:0090237 [regulation of arachidonic acid secretion] GO:0090330 [regulation of platelet aggregation] GO:0120162 [positive regulation of cold-induced thermogenesis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0001525 [angiogenesis] GO:0001784 [phosphotyrosine residue binding] GO:0001945 [lymph vessel development] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002281 [macrophage activation involved in immune response] GO:0002283 [neutrophil activation involved in immune response] GO:0002366 [leukocyte activation involved in immune response] GO:0002376 [immune system process] GO:0002554 [serotonin secretion by platelet] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [signaling receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006606 [protein import into nucleus] GO:0007159 [leukocyte cell-cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0009887 [animal organ morphogenesis] GO:0010543 [regulation of platelet activation] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016170 [interleukin-15 receptor binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030593 [neutrophil chemotaxis] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031623 [receptor internalization] GO:0032009 [early phagosome] GO:0032733 [positive regulation of interleukin-10 production] GO:0032735 [positive regulation of interleukin-12 production] GO:0032753 [positive regulation of interleukin-4 production] GO:0032755 [positive regulation of interleukin-6 production] GO:0032757 [positive regulation of interleukin-8 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0032928 [regulation of superoxide anion generation] GO:0032930 [positive regulation of superoxide anion generation] GO:0032991 [protein-containing complex] GO:0033630 [positive regulation of cell adhesion mediated by integrin] GO:0035556 [intracellular signal transduction] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0038110 [interleukin-2-mediated signaling pathway] GO:0038156 [interleukin-3-mediated signaling pathway] GO:0042101 [T cell receptor complex] GO:0042127 [regulation of cell population proliferation] GO:0042742 [defense response to bacterium] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043306 [positive regulation of mast cell degranulation] GO:0043313 [regulation of neutrophil degranulation] GO:0045087 [innate immune response] GO:0045579 [positive regulation of B cell differentiation] GO:0045780 [positive regulation of bone resorption] GO:0046641 [positive regulation of alpha-beta T cell proliferation] GO:0048514 [blood vessel morphogenesis] GO:0050764 [regulation of phagocytosis] GO:0050853 [B cell receptor signaling pathway] GO:0051090 [regulation of DNA-binding transcription factor activity] GO:0051712 [positive regulation of killing of cells of other organism] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0071226 [cellular response to molecule of fungal origin] GO:0071404 [cellular response to low-density lipoprotein particle stimulus] GO:0071639 [positive regulation of monocyte chemotactic protein-1 production] GO:0090237 [regulation of arachidonic acid secretion] GO:0090330 [regulation of platelet aggregation] GO:0120162 [positive regulation of cold-induced thermogenesis]