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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q11.21
Chromosome location (bp)
43077064 - 43130351
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
RET-201
RET-202
RET-204
RET-205
RET-206
RET-207
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P07949 [Direct mapping] Proto-oncogene tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment
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Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the lung and pleura Cancers of endocrine organs Congenital malformations Congenital malformations of the digestive system Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007158 [neuron cell-cell adhesion] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007275 [multicellular organism development] GO:0007411 [axon guidance] GO:0007497 [posterior midgut development] GO:0010008 [endosome membrane] GO:0010976 [positive regulation of neuron projection development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030155 [regulation of cell adhesion] GO:0030335 [positive regulation of cell migration] GO:0030424 [axon] GO:0033619 [membrane protein proteolysis] GO:0033630 [positive regulation of cell adhesion mediated by integrin] GO:0033674 [positive regulation of kinase activity] GO:0035860 [glial cell-derived neurotrophic factor receptor signaling pathway] GO:0038023 [signaling receptor activity] GO:0043235 [receptor complex] GO:0043410 [positive regulation of MAPK cascade] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048265 [response to pain] GO:0051897 [positive regulation of protein kinase B signaling] GO:0061146 [Peyer's patch morphogenesis] GO:0071300 [cellular response to retinoic acid] GO:0072300 [positive regulation of metanephric glomerulus development] GO:0097021 [lymphocyte migration into lymphoid organs] GO:0098797 [plasma membrane protein complex] GO:2001241 [positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
P07949 [Direct mapping] Proto-oncogene tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment A0A024R7T2 [Target identity:100%; Query identity:100%] Proto-oncogene tyrosine-protein kinase receptor Ret
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Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the lung and pleura Cancers of endocrine organs Congenital malformations Congenital malformations of the digestive system Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0000187 [activation of MAPK activity] GO:0001657 [ureteric bud development] GO:0001755 [neural crest cell migration] GO:0001838 [embryonic epithelial tube formation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007158 [neuron cell-cell adhesion] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0007497 [posterior midgut development] GO:0010008 [endosome membrane] GO:0010628 [positive regulation of gene expression] GO:0010976 [positive regulation of neuron projection development] GO:0014042 [positive regulation of neuron maturation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030155 [regulation of cell adhesion] GO:0030182 [neuron differentiation] GO:0030335 [positive regulation of cell migration] GO:0030424 [axon] GO:0030425 [dendrite] GO:0033141 [positive regulation of peptidyl-serine phosphorylation of STAT protein] GO:0033619 [membrane protein proteolysis] GO:0033630 [positive regulation of cell adhesion mediated by integrin] GO:0033674 [positive regulation of kinase activity] GO:0035799 [ureter maturation] GO:0035860 [glial cell-derived neurotrophic factor receptor signaling pathway] GO:0038023 [signaling receptor activity] GO:0042493 [response to drug] GO:0042551 [neuron maturation] GO:0043025 [neuronal cell body] GO:0043235 [receptor complex] GO:0043410 [positive regulation of MAPK cascade] GO:0045121 [membrane raft] GO:0045793 [positive regulation of cell size] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048265 [response to pain] GO:0048484 [enteric nervous system development] GO:0050770 [regulation of axonogenesis] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060041 [retina development in camera-type eye] GO:0060384 [innervation] GO:0061146 [Peyer's patch morphogenesis] GO:0071300 [cellular response to retinoic acid] GO:0072300 [positive regulation of metanephric glomerulus development] GO:0097021 [lymphocyte migration into lymphoid organs] GO:0098797 [plasma membrane protein complex] GO:2001241 [positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
A0A1W2PPN7 [Direct mapping] Proto-oncogene tyrosine-protein kinase receptor Ret
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Cancers of the lung and pleura Cancers of endocrine organs Congenital malformations Congenital malformations of the digestive system Nervous system diseases Other nervous and sensory system diseases Protein evidence (Ezkurdia et al 2014)
A0A1W2PSA1 [Direct mapping] Proto-oncogene tyrosine-protein kinase receptor Ret
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SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Cancers of the lung and pleura Cancers of endocrine organs Congenital malformations Congenital malformations of the digestive system Nervous system diseases Other nervous and sensory system diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
