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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:1686.1 nTPM
HPA:1686.1 nTPM
GTEx:2148.7 nTPM
FANTOM5:862.8 Scaled Tags Per Million
Pig:601.4 nTPM
Mouse:1336.8 nTPM
Allen mouse:12.9 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 1686.1
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 1594.0
2586 Male, age 75, left hemisphere 1814.6
2828 Female, age 72, unknown 1738.7
2219 Male, age 76, both hemispheres 1600.6
1827 Male, age 72, unknown 1577.9
2666 Male, age 74, left hemisphere 1560.5
2411 Female, age 72, unknown 1559.9
1870 Female, age 42, unknown 1558.2
1833 Male, age 53, unknown 1554.2
1830 Male, age 51, unknown 1521.9
2019 Male, age 18, unknown 1454.0
Dorsal raphe nucleus
nTPM: 1677.3
2016 Female, age 72, unknown 1803.0
1828 Male, age 53, unknown 1717.5
2047 Male, age 72, unknown 1678.7
2298 Female, age 72, unknown 1618.1
2750 Male, age 76, both hemispheres 1569.4
Inferior colliculus
nTPM: 1654.2
1890 Male, age 53, unknown 1697.4
2849 Male, age 72, unknown 1680.9
1848 Female, age 42, unknown 1671.9
2097 Female, age 72, unknown 1566.4
Median raphe nucleus
nTPM: 1525.2
2220 Male, age 76, midline 1525.2
Pedunculopontine tegmental nucleus
nTPM: 1508.8
1921 Female, age 85, both hemispheres 1662.3
2334 Male, age 80, both hemispheres 1555.9
2338 Male, age 61, both hemispheres 1308.2
Periaquaductal grey, anterior
nTPM: 1610.8
1795 Male, age 51, unknown 1625.1
2502 Female, age 75, unknown 1616.3
1947 Male, age 18, unknown 1591.1
Periaquaductal grey, dorsal
nTPM: 1686.1
1840 Male, age 53, unknown 1810.6
2850 Male, age 76, both hemispheres 1737.2
2464 Female, age 72, unknown 1665.1
1831 Male, age 72, unknown 1531.7
Periaquaductal grey, lateral
nTPM: 1599.0
2053 Male, age 18, unknown 1686.9
2140 Male, age 76, both hemispheres 1648.4
2272 Male, age 74, both hemispheres 1461.8
Pretectal area
nTPM: 1622.9
2667 Female, age 75, unknown 1730.0
2316 Male, age 76, right hemisphere 1676.2
1817 Female, age 42, unknown 1674.3
2825 Male, age 18, unknown 1653.7
1815 Male, age 53, unknown 1643.3
1944 Female, age 72, unknown 1630.8
1816 Male, age 51, unknown 1612.6
2224 Female, age 72, unknown 1596.4
2407 Male, age 75, both hemispheres 1561.6
2273 Male, age 74, both hemispheres 1550.3
2007 Male, age 72, unknown 1523.2
Red nucleus
nTPM: 1655.7
2503 Female, age 72, unknown 1784.4
2769 Male, age 72, unknown 1765.2
2227 Male, age 72, unknown 1748.3
1904 Male, age 53, unknown 1695.2
1821 Female, age 72, unknown 1686.7
2588 Male, age 74, left hemisphere 1675.0
1954 Female, age 42, unknown 1674.6
2823 Male, age 76, right hemisphere 1648.9
1865 Male, age 51, unknown 1644.2
2725 Female, age 75, unknown 1531.8
2584 Male, age 75, left hemisphere 1525.2
2785 Male, age 18, unknown 1488.7
Substantia nigra
nTPM: 1671.7
2699 Male, age 18, unknown 2026.0
2665 Male, age 74, both hemispheres 1737.7
1851 Male, age 51, unknown 1711.0
1916 Female, age 42, unknown 1680.6
1889 Female, age 72, unknown 1648.8
2241 Male, age 72, unknown 1630.5
2583 Male, age 75, right hemisphere 1623.8
2409 Female, age 72, unknown 1616.5
2590 Female, age 75, unknown 1580.8
1941 Male, age 53, unknown 1461.2
Superior colliculus
nTPM: 1635.2
2668 Female, age 75, unknown 1738.2
1995 Male, age 72, unknown 1707.1
2664 Male, age 75, both hemispheres 1663.2
2087 Female, age 72, unknown 1630.9
1839 Male, age 51, unknown 1623.2
1796 Male, age 53, unknown 1619.8
1895 Male, age 76, right hemisphere 1605.1
2261 Male, age 18, unknown 1600.5
1913 Female, age 42, unknown 1595.5
2587 Male, age 74, left hemisphere 1568.4
Ventral tegmental area
nTPM: 1591.1
2410 Female, age 72, unknown 1681.0
1915 Female, age 42, unknown 1633.6
1942 Male, age 51, unknown 1614.4
2021 Male, age 53, unknown 1599.9
2218 Male, age 76, both hemispheres 1557.3
2223 Female, age 72, unknown 1460.3

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 2148.7
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 2148.7
Samples: 139

Max nTPM: 4652.2
Min nTPM: 442.8
Std nTPM: 884.6
Median nTPM: 2034.4
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 4652.2
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 4316.9
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 4238.3
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 4216.7
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 4142.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 3993.6
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 3978.7
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 3677.3
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 3661.1
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 3627.2
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 3613.9
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 3595.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 3561.4
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 3471.7
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 3463.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 3383.0
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 3380.0
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 3296.0
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 3262.9
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 3161.5
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 3074.8
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 3031.9
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 2989.0
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 2960.9
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 2948.4
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 2945.3
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 2852.6
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 2806.5
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 2804.2
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 2786.7
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 2755.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 2682.8
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 2680.9
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 2670.7
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 2662.6
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 2662.3
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 2652.4
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 2576.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 2569.5
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 2567.0
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 2554.5
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 2553.0
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 2538.8
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 2501.7
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 2488.6
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 2467.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 2457.5
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 2428.2
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 2388.5
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 2372.7
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 2360.5
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 2359.3
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 2358.7
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 2252.7
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 2245.5
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 2237.4
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 2228.1
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 2208.7
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 2205.8
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 2191.9
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 2185.5
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 2172.3
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 2157.1
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 2131.3
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 2123.2
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 2088.0
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 2084.7
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 2079.4
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 2066.7
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 2034.4
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 2028.7
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 2025.8
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 2022.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 2011.9
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 2005.0
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 2004.4
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 1980.1
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 1911.5
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 1910.4
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 1906.1
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 1841.7
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 1829.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 1827.6
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 1820.7
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 1817.2
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 1811.3
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 1809.4
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 1779.9
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 1779.6
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 1775.4
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 1711.7
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 1709.7
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 1703.8
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 1688.8
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 1630.5
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 1618.9
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 1614.2
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 1593.5
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 1577.9
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 1568.1
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 1556.4
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 1555.4
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 1492.4
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 1475.9
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 1467.4
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 1464.8
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 1461.8
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 1454.0
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 1446.3
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 1440.7
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 1428.4
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 1379.9
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 1367.0
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 1365.2
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 1298.9
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 1291.7
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 1285.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 1274.8
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 1266.6
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 1260.1
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 1224.3
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 1184.5
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 1151.0
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 1117.7
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 1115.7
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 1108.7
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 1087.0
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 1065.6
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 1050.8
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 1015.4
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 1006.4
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 965.0
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 913.6
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 743.7
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 624.8
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 544.0
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 533.8
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 531.1
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 442.8
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 862.8
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 862.8
FF:10158-103A5 76 years, female 862.8

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 601.4
Pig sample Sample description nTPM
Midbrain
nTPM: 589.5
Samples: 4

Max nTPM: 748.0
Min nTPM: 460.1
Sample A Female 594.6
Sample B Female 748.0
Sample C Male 555.4
Sample D Male 460.1
Periaqueductal gray
nTPM: 601.3
Samples: 3

Max nTPM: 691.6
Min nTPM: 501.6
Sample B Female 691.6
Sample C Male 610.8
Sample D Male 501.6
Substantia nigra
nTPM: 594.2
Samples: 4

Max nTPM: 710.8
Min nTPM: 479.2
Sample A Female 710.8
Sample B Female 479.2
Sample C Male 574.4
Sample D Male 612.2
Superior colliculi
nTPM: 568.7
Samples: 4

Max nTPM: 768.5
Min nTPM: 360.3
Sample A Female 768.5
Sample B Female 360.3
Sample C Male 562.7
Sample D Male 583.4

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 1336.8
Mouse sample Sample description nTPM
Midbrain
nTPM: 1336.8
Samples: 4

Max nTPM: 1413.0
Min nTPM: 1242.4
Sample A Male 1413.0
Sample B Male 1242.4
Sample C Female 1291.8
Sample D Female 1400.1

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 12.9
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 12.9
79568051 Antisense, RP_071204_02_C04, Mouse strain C57BL/6J (56 days, male) 15.5
79912570 Antisense, RP_071204_02_C04, Mouse strain C57BL/6J (56 days, male) 11.3
1238 Antisense, RP_Baylor_103165, Mouse strain C57BL/6J (56 days, male) 10.3
1237 Antisense, RP_Baylor_103165, Mouse strain C57BL/6J (56 days, male) 6.8

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The Human Protein Atlas

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.