We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
ILK
SECTIONS
  • TISSUE
  • BRAIN
  • SINGLE CELL TYPE
  • TISSUE CELL TYPE
  • PATHOLOGY
  • DISEASE
  • IMMUNE CELL
  • BLOOD PROTEIN
  • SUBCELLULAR
  • CELL LINE
  • STRUCTURE
  • METABOLIC
ABOUT
  • INTRODUCTION
  • HISTORY
  • ORGANIZATION
  • PUBLICATIONS
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • ACKNOWLEDGMENTS
  • CONTACT
NEWS
  • NEWS ARTICLES
  • PRESS ROOM
LEARN
  • DICTIONARY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
  • METHODS
  • EDUCATIONAL VIDEOS
DATA
  • DOWNLOADABLE DATA
  • PUBLICATION DATA
  • RELEASE HISTORY
  • SARS-COV-2
HELP
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • HELP & FAQ
  • PRIVACY STATEMENT
  • LICENCE & CITATION
Fields »
Search result

Field
Term
Gene name
Class
Subclass
Class
Keyword
Chromosome
External id
Tissue
Cell type
Expression
Patient ID
Tissue
Category
Cluster
Reliability
Brain region
Category
Brain region
Category
Brain region
Category
Reliability
Cell type
Category
Cluster
Tissue
Cell type
Enrichment
Cancer
Prognosis
Cancer
Category
Cell type
Category
Cell lineage
Category
Cluster
Annotation
Disease
Location
Searches
Location
Cell line
Type
Phase
Reliability
Cancer type
Category
Cluster
Pathway
Category
Score
Score
Score
Validation
Validation
Validation
Validation
Antibodies
Protein structure
In atlas
Column


  • SUMMARY

  • TISSUE

  • BRAIN

  • SINGLE CELL

  • TISSUE CELL

  • PATHOLOGY

  • DISEASE

  • IMMUNE

  • BLOOD

  • SUBCELL

  • CELL LINE

  • STRUCTURE

  • METABOLIC

  • ILK
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

ILK
Synonyms
Gene descriptioni

Full gene name according to HGNC.

Integrin linked kinase
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Enzymes
Plasma proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 11
Cytoband p15.4
Chromosome location (bp) 6603708 - 6610874
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

8
Ensembl ENSG00000166333 (version 103.38)
Entrez gene 3611
HGNC HGNC:6040
UniProt Q13418 (UniProt - Evidence at protein level)
neXtProt NX_Q13418
Antibodypedia ILK antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 258

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

Off
On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
ILK-201
ILK-202
ILK-203
ILK-206
ILK-210
ILK-212
ILK-215
ILK-216


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
ILK-201
ENSP00000299421
ENST00000299421
Q13418 [Direct mapping]
Integrin-linked protein kinase
V9HWF0 [Target identity:100%; Query identity:100%]
Integrin-linked protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000902 [cell morphogenesis]
GO:0001725 [stress fiber]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0019901 [protein kinase binding]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0042327 [positive regulation of phosphorylation]
GO:0042995 [cell projection]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070527 [platelet aggregation]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0106310 []
GO:0106311 []
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
Show all
452 aa
51.4 kDa
No 0
ILK-202
ENSP00000379975
ENST00000396751
Q13418 [Direct mapping]
Integrin-linked protein kinase
V9HWF0 [Target identity:100%; Query identity:100%]
Integrin-linked protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000902 [cell morphogenesis]
GO:0001725 [stress fiber]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0019901 [protein kinase binding]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0042327 [positive regulation of phosphorylation]
GO:0042995 [cell projection]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070527 [platelet aggregation]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0106310 []
GO:0106311 []
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
Show all
452 aa
51.4 kDa
No 0
ILK-203
ENSP00000403487
ENST00000420936
Q13418 [Direct mapping]
Integrin-linked protein kinase
V9HWF0 [Target identity:100%; Query identity:100%]
Integrin-linked protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000902 [cell morphogenesis]
GO:0001725 [stress fiber]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0019901 [protein kinase binding]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0042327 [positive regulation of phosphorylation]
GO:0042995 [cell projection]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070527 [platelet aggregation]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0106310 []
GO:0106311 []
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
Show all
452 aa
51.4 kDa
No 0
ILK-206
ENSP00000480597
ENST00000526318
A0A087WWY6 [Direct mapping]
Integrin-linked protein kinase
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
111 aa
12.5 kDa
No 0
ILK-210
ENSP00000435323
ENST00000528995
Q13418 [Direct mapping]
Integrin-linked protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000902 [cell morphogenesis]
GO:0001725 [stress fiber]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0019901 [protein kinase binding]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0042327 [positive regulation of phosphorylation]
GO:0042995 [cell projection]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070527 [platelet aggregation]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0106310 []
GO:0106311 []
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
Show all
391 aa
44.3 kDa
No 0
ILK-212
ENSP00000434492
ENST00000532063
Q13418 [Direct mapping]
Integrin-linked protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000902 [cell morphogenesis]
GO:0001725 [stress fiber]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0019901 [protein kinase binding]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0042327 [positive regulation of phosphorylation]
GO:0042995 [cell projection]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070527 [platelet aggregation]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0106310 []
GO:0106311 []
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
Show all
318 aa
36.5 kDa
No 0
ILK-215
ENSP00000439606
ENST00000537806
A0A0A0MTH3 [Direct mapping]
Integrin-linked protein kinase
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001725 [stress fiber]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0003151 [outflow tract morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007050 [cell cycle arrest]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007569 [cell aging]
GO:0008284 [positive regulation of cell population proliferation]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0010761 [fibroblast migration]
GO:0014044 [Schwann cell development]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0017124 [SH3 domain binding]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019904 [protein domain specific binding]
GO:0021675 [nerve development]
GO:0022011 [myelination in peripheral nervous system]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0032288 [myelin assembly]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0032991 [protein-containing complex]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0043025 [neuronal cell body]
GO:0043034 [costamere]
GO:0043066 [negative regulation of apoptotic process]
GO:0043195 [terminal bouton]
GO:0043198 [dendritic shaft]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043491 [protein kinase B signaling]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044877 [protein-containing complex binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045773 [positive regulation of axon extension]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0048812 [neuron projection morphogenesis]
GO:0050772 [positive regulation of axonogenesis]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0097435 [supramolecular fiber organization]
GO:2000178 [negative regulation of neural precursor cell proliferation]
Show all
483 aa
54.6 kDa
No 0
ILK-216
ENSP00000487498
ENST00000627400
E9PQ52 [Direct mapping]
Integrin-linked protein kinase
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
36 aa
4.1 kDa
No 0

Contact

  • NEWS ARTICLES
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS

The Human Protein Atlas

  • DOWNLOADABLE DATA
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.