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SMAD3
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  • SMAD3
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

SMAD3
Synonyms HsT17436, JV15-2, MADH3
Gene descriptioni

Full gene name according to HGNC.

SMAD family member 3
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Disease related genes
Human disease related genes
Transcription factors
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 15
Cytoband q22.33
Chromosome location (bp) 67063763 - 67195173
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

14
Ensembl ENSG00000166949 (version 103.38)
Entrez gene 4088
HGNC HGNC:6769
UniProt P84022 (UniProt - Evidence at protein level)
neXtProt NX_P84022
Antibodypedia SMAD3 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 14      # Population variants: 141

Experimental


Description: MH2 domain of transcriptional factor SMAD3 (X-ray)

# Chains: 1      # Clinical variants: 0      # Population variants: 0

Antigens:

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On

Variants:

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Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
«
SMAD3-201
SMAD3-202
SMAD3-203
SMAD3-204
SMAD3-205
SMAD3-206
SMAD3-208
SMAD3-209
SMAD3-210
SMAD3-211
SMAD3-213
SMAD3-215
SMAD3-216
SMAD3-218
»


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
SMAD3-201
ENSP00000332973
ENST00000327367
P84022 [Direct mapping]
Mothers against decapentaplegic homolog 3
A0A024R5Z3 [Target identity:100%; Query identity:100%]
Mothers against decapentaplegic homolog
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001223 [transcription coactivator binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0001657 [ureteric bud development]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001707 [mesoderm formation]
GO:0001756 [somitogenesis]
GO:0001889 [liver development]
GO:0001947 [heart looping]
GO:0002076 [osteoblast development]
GO:0002520 [immune system development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005634 [nucleus]
GO:0005637 [nuclear inner membrane]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006955 [immune response]
GO:0007050 [cell cycle arrest]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007183 [SMAD protein complex assembly]
GO:0007369 [gastrulation]
GO:0007492 [endoderm development]
GO:0008013 [beta-catenin binding]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0009880 [embryonic pattern specification]
GO:0010628 [positive regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016032 [viral process]
GO:0016202 [regulation of striated muscle tissue development]
GO:0016579 [protein deubiquitination]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0017151 [DEAD/H-box RNA helicase binding]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030325 [adrenal gland development]
GO:0030335 [positive regulation of cell migration]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030878 [thyroid gland development]
GO:0031053 [primary miRNA processing]
GO:0031490 [chromatin DNA binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031962 [mineralocorticoid receptor binding]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032909 [regulation of transforming growth factor beta2 production]
GO:0032916 [positive regulation of transforming growth factor beta3 production]
GO:0032924 [activin receptor signaling pathway]
GO:0032991 [protein-containing complex]
GO:0033689 [negative regulation of osteoblast proliferation]
GO:0035259 [glucocorticoid receptor binding]
GO:0038092 [nodal signaling pathway]
GO:0042060 [wound healing]
GO:0042110 [T cell activation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043130 [ubiquitin binding]
GO:0043235 [receptor complex]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045216 [cell-cell junction organization]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048340 [paraxial mesoderm morphogenesis]
GO:0048589 [developmental growth]
GO:0048617 [embryonic foregut morphogenesis]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0050678 [regulation of epithelial cell proliferation]
GO:0050728 [negative regulation of inflammatory response]
GO:0050776 [regulation of immune response]
GO:0050821 [protein stabilization]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051098 [regulation of binding]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0060039 [pericardium development]
GO:0060290 [transdifferentiation]
GO:0060395 [SMAD protein signal transduction]
GO:0061045 [negative regulation of wound healing]
GO:0061767 [negative regulation of lung blood pressure]
GO:0070306 [lens fiber cell differentiation]
GO:0070410 [co-SMAD binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0071141 [SMAD protein complex]
GO:0071144 [heteromeric SMAD protein complex]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:1901203 [positive regulation of extracellular matrix assembly]
GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II]
GO:1903243 [negative regulation of cardiac muscle hypertrophy in response to stress]
Show all
425 aa
48.1 kDa
No 0
SMAD3-202
ENSP00000401133
ENST00000439724
P84022 [Direct mapping]
Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001223 [transcription coactivator binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001666 [response to hypoxia]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005637 [nuclear inner membrane]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006955 [immune response]
GO:0007050 [cell cycle arrest]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007183 [SMAD protein complex assembly]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009653 [anatomical structure morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016032 [viral process]
GO:0016579 [protein deubiquitination]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0017151 [DEAD/H-box RNA helicase binding]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030509 [BMP signaling pathway]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031053 [primary miRNA processing]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031962 [mineralocorticoid receptor binding]
GO:0032909 [regulation of transforming growth factor beta2 production]
GO:0032924 [activin receptor signaling pathway]
GO:0035259 [glucocorticoid receptor binding]
GO:0038092 [nodal signaling pathway]
GO:0042060 [wound healing]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043130 [ubiquitin binding]
GO:0043235 [receptor complex]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045216 [cell-cell junction organization]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0060395 [SMAD protein signal transduction]
GO:0070410 [co-SMAD binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0071141 [SMAD protein complex]
GO:0071144 [heteromeric SMAD protein complex]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1901203 [positive regulation of extracellular matrix assembly]
GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II]
Show all
381 aa
43.2 kDa
No 0
SMAD3-203
ENSP00000445348
ENST00000537194
P84022 [Direct mapping]
Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001223 [transcription coactivator binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001666 [response to hypoxia]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005637 [nuclear inner membrane]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006955 [immune response]
GO:0007050 [cell cycle arrest]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007183 [SMAD protein complex assembly]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009653 [anatomical structure morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016032 [viral process]
GO:0016579 [protein deubiquitination]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0017151 [DEAD/H-box RNA helicase binding]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030509 [BMP signaling pathway]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031053 [primary miRNA processing]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031962 [mineralocorticoid receptor binding]
GO:0032909 [regulation of transforming growth factor beta2 production]
GO:0032924 [activin receptor signaling pathway]
GO:0035259 [glucocorticoid receptor binding]
GO:0038092 [nodal signaling pathway]
GO:0042060 [wound healing]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043130 [ubiquitin binding]
GO:0043235 [receptor complex]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045216 [cell-cell junction organization]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0060395 [SMAD protein signal transduction]
GO:0070410 [co-SMAD binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0071141 [SMAD protein complex]
GO:0071144 [heteromeric SMAD protein complex]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1901203 [positive regulation of extracellular matrix assembly]
GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II]
Show all
230 aa
25.7 kDa
No 0
SMAD3-204
ENSP00000437757
ENST00000540846
P84022 [Direct mapping]
Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001223 [transcription coactivator binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001666 [response to hypoxia]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005637 [nuclear inner membrane]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006955 [immune response]
GO:0007050 [cell cycle arrest]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007183 [SMAD protein complex assembly]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009653 [anatomical structure morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016032 [viral process]
GO:0016579 [protein deubiquitination]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0017151 [DEAD/H-box RNA helicase binding]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030509 [BMP signaling pathway]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031053 [primary miRNA processing]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031962 [mineralocorticoid receptor binding]
GO:0032909 [regulation of transforming growth factor beta2 production]
GO:0032924 [activin receptor signaling pathway]
GO:0035259 [glucocorticoid receptor binding]
GO:0038092 [nodal signaling pathway]
GO:0042060 [wound healing]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043130 [ubiquitin binding]
GO:0043235 [receptor complex]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045216 [cell-cell junction organization]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0060395 [SMAD protein signal transduction]
GO:0070410 [co-SMAD binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0071141 [SMAD protein complex]
GO:0071144 [heteromeric SMAD protein complex]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1901203 [positive regulation of extracellular matrix assembly]
GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II]
Show all
320 aa
35.9 kDa
No 0
SMAD3-205
ENSP00000454165
ENST00000558428
H0YNV1 [Direct mapping]
Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
84 aa
9.3 kDa
No 0
SMAD3-206
ENSP00000453684
ENST00000558739
H0YMP2 [Direct mapping]
Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
63 aa
7.3 kDa
No 0
SMAD3-208
ENSP00000452767
ENST00000558827
H0YKE2 [Direct mapping]
Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
112 aa
12.5 kDa
No 0
SMAD3-209
ENSP00000458060
ENST00000558894
H3BVD1 [Direct mapping]
Mothers against decapentaplegic homolog
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0046872 [metal ion binding]
Show all
213 aa
23.8 kDa
No 0
SMAD3-210
ENSP00000453788
ENST00000559092
H0YMY0 [Direct mapping]
Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
96 aa
10.4 kDa
No 0
SMAD3-211
ENSP00000453082
ENST00000559460
H0YL71 [Direct mapping]
Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
92 aa
10.4 kDa
No 0
SMAD3-213
ENSP00000455095
ENST00000560175
H3BP09 [Direct mapping]
Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
114 aa
12.7 kDa
No 0
SMAD3-215
ENSP00000455540
ENST00000560424
H3BQ00 [Direct mapping]
Mothers against decapentaplegic homolog 3
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
156 aa
17.2 kDa
No 0
SMAD3-216
ENSP00000505445
ENST00000679624
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005667 [transcription regulator complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
320 aa
35.9 kDa
No 0
SMAD3-218
ENSP00000505641
ENST00000681239
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005667 [transcription regulator complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
320 aa
35.9 kDa
No 0

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