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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
p21.2
Chromosome location (bp)
23678697 - 23682938
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
NKX3-1-201
NKX3-1-202
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Human disease related genes Cancers Cancers of male genital organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001655 [urogenital system development] GO:0001656 [metanephros development] GO:0001756 [somitogenesis] GO:0001934 [positive regulation of protein phosphorylation] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007275 [multicellular organism development] GO:0007431 [salivary gland development] GO:0007507 [heart development] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008285 [negative regulation of cell population proliferation] GO:0008584 [male gonad development] GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010942 [positive regulation of cell death] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0030154 [cell differentiation] GO:0030284 [estrogen receptor activity] GO:0030331 [estrogen receptor binding] GO:0030521 [androgen receptor signaling pathway] GO:0030850 [prostate gland development] GO:0032880 [regulation of protein localization] GO:0033574 [response to testosterone] GO:0035690 [cellular response to drug] GO:0035907 [dorsal aorta development] GO:0042826 [histone deacetylase binding] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043491 [protein kinase B signaling] GO:0043565 [sequence-specific DNA binding] GO:0043569 [negative regulation of insulin-like growth factor receptor signaling pathway] GO:0043621 [protein self-association] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051781 [positive regulation of cell division] GO:0060037 [pharyngeal system development] GO:0060442 [branching involved in prostate gland morphogenesis] GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis] GO:0060770 [negative regulation of epithelial cell proliferation involved in prostate gland development] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071383 [cellular response to steroid hormone stimulus] GO:0071456 [cellular response to hypoxia] GO:0071850 [mitotic cell cycle arrest] GO:0071899 [negative regulation of estrogen receptor binding] GO:0090734 [site of DNA damage] GO:0097162 [MADS box domain binding] GO:1990837 [sequence-specific double-stranded DNA binding] GO:2000836 [positive regulation of androgen secretion] GO:2001022 [positive regulation of response to DNA damage stimulus] GO:2001235 [positive regulation of apoptotic signaling pathway] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Human disease related genes Cancers Cancers of male genital organs Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001934 [positive regulation of protein phosphorylation] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007275 [multicellular organism development] GO:0007431 [salivary gland development] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008285 [negative regulation of cell population proliferation] GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010942 [positive regulation of cell death] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0030154 [cell differentiation] GO:0030284 [estrogen receptor activity] GO:0030331 [estrogen receptor binding] GO:0030521 [androgen receptor signaling pathway] GO:0032880 [regulation of protein localization] GO:0033574 [response to testosterone] GO:0035690 [cellular response to drug] GO:0042826 [histone deacetylase binding] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043491 [protein kinase B signaling] GO:0043565 [sequence-specific DNA binding] GO:0043569 [negative regulation of insulin-like growth factor receptor signaling pathway] GO:0043621 [protein self-association] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051781 [positive regulation of cell division] GO:0060442 [branching involved in prostate gland morphogenesis] GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis] GO:0060770 [negative regulation of epithelial cell proliferation involved in prostate gland development] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071383 [cellular response to steroid hormone stimulus] GO:0071456 [cellular response to hypoxia] GO:0071850 [mitotic cell cycle arrest] GO:0071899 [negative regulation of estrogen receptor binding] GO:0090734 [site of DNA damage] GO:1990837 [sequence-specific double-stranded DNA binding] GO:2000836 [positive regulation of androgen secretion] GO:2001022 [positive regulation of response to DNA damage stimulus] GO:2001235 [positive regulation of apoptotic signaling pathway] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
