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NOD2
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  • NOD2
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

NOD2
Synonyms BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, PSORAS1
Gene descriptioni

Full gene name according to HGNC.

Nucleotide binding oligomerization domain containing 2
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Disease related genes
FDA approved drug targets
Human disease related genes
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 16
Cytoband q12.1
Chromosome location (bp) 50693588 - 50734041
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

4
Ensembl ENSG00000167207 (version 103.38)
Entrez gene 64127
HGNC HGNC:5331
UniProt Q9HC29 (UniProt - Evidence at protein level)
neXtProt NX_Q9HC29
Antibodypedia NOD2 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 16      # Population variants: 736

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
NOD2-201
NOD2-207
NOD2-209
NOD2-213


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
NOD2-201
ENSP00000300589
ENST00000300589
Q9HC29 [Direct mapping]
Nucleotide-binding oligomerization domain-containing protein 2
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Immune system diseases
   Allergies and autoimmune diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0000187 [activation of MAPK activity]
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0002227 [innate immune response in mucosa]
GO:0002253 [activation of immune response]
GO:0002367 [cytokine production involved in immune response]
GO:0002376 [immune system process]
GO:0002606 [positive regulation of dendritic cell antigen processing and presentation]
GO:0002710 [negative regulation of T cell mediated immunity]
GO:0002732 [positive regulation of dendritic cell cytokine production]
GO:0002830 [positive regulation of type 2 immune response]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0002925 [positive regulation of humoral immune response mediated by circulating immunoglobulin]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006952 [defense response]
GO:0006963 [positive regulation of antibacterial peptide biosynthetic process]
GO:0006965 [positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria]
GO:0007254 [JNK cascade]
GO:0007584 [response to nutrient]
GO:0008284 [positive regulation of cell population proliferation]
GO:0009595 [detection of biotic stimulus]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016045 [detection of bacterium]
GO:0016323 [basolateral plasma membrane]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030277 [maintenance of gastrointestinal epithelium]
GO:0030544 [Hsp70 protein binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031982 [vesicle]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032494 [response to peptidoglycan]
GO:0032495 [response to muramyl dipeptide]
GO:0032496 [response to lipopolysaccharide]
GO:0032498 [detection of muramyl dipeptide]
GO:0032500 [muramyl dipeptide binding]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032695 [negative regulation of interleukin-12 production]
GO:0032701 [negative regulation of interleukin-18 production]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0032991 [protein-containing complex]
GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0038187 [pattern recognition receptor activity]
GO:0042742 [defense response to bacterium]
GO:0042834 [peptidoglycan binding]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043330 [response to exogenous dsRNA]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044877 [protein-containing complex binding]
GO:0045087 [innate immune response]
GO:0045089 [positive regulation of innate immune response]
GO:0045335 [phagocytic vesicle]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046645 [positive regulation of gamma-delta T cell activation]
GO:0046658 [anchored component of plasma membrane]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050700 [CARD domain binding]
GO:0050727 [regulation of inflammatory response]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050766 [positive regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0050871 [positive regulation of B cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0051770 [positive regulation of nitric-oxide synthase biosynthetic process]
GO:0051879 [Hsp90 protein binding]
GO:0060585 [positive regulation of prostaglandin-endoperoxide synthase activity]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071224 [cellular response to peptidoglycan]
GO:0071225 [cellular response to muramyl dipeptide]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0090022 [regulation of neutrophil chemotaxis]
GO:1900017 [positive regulation of cytokine production involved in inflammatory response]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1902523 [positive regulation of protein K63-linked ubiquitination]
GO:1904417 [positive regulation of xenophagy]
GO:2000110 [negative regulation of macrophage apoptotic process]
GO:2000363 [positive regulation of prostaglandin-E synthase activity]
Show all
1040 aa
115.3 kDa
No 0
NOD2-207
ENSP00000431681
ENST00000531674
E9PK30 [Direct mapping]
Nucleotide-binding oligomerization domain-containing protein 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Allergies and autoimmune diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Show all
GO:0042981 [regulation of apoptotic process]
Show all
146 aa
16.8 kDa
No 0
NOD2-209
ENSP00000437246
ENST00000534057
H0YF53 [Direct mapping]
Nucleotide-binding oligomerization domain-containing protein 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Allergies and autoimmune diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Show all
GO:0005515 [protein binding]
Show all
169 aa
17.9 kDa
No 0
NOD2-213
ENSP00000495993
ENST00000647318
Q9HC29 [Direct mapping]
Nucleotide-binding oligomerization domain-containing protein 2
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Immune system diseases
   Allergies and autoimmune diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0000187 [activation of MAPK activity]
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0002367 [cytokine production involved in immune response]
GO:0002376 [immune system process]
GO:0002606 [positive regulation of dendritic cell antigen processing and presentation]
GO:0002830 [positive regulation of type 2 immune response]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006952 [defense response]
GO:0007254 [JNK cascade]
GO:0009595 [detection of biotic stimulus]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016045 [detection of bacterium]
GO:0016323 [basolateral plasma membrane]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030277 [maintenance of gastrointestinal epithelium]
GO:0030544 [Hsp70 protein binding]
GO:0031982 [vesicle]
GO:0032495 [response to muramyl dipeptide]
GO:0032498 [detection of muramyl dipeptide]
GO:0032500 [muramyl dipeptide binding]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0032991 [protein-containing complex]
GO:0035556 [intracellular signal transduction]
GO:0038187 [pattern recognition receptor activity]
GO:0042742 [defense response to bacterium]
GO:0042834 [peptidoglycan binding]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044877 [protein-containing complex binding]
GO:0045087 [innate immune response]
GO:0045335 [phagocytic vesicle]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046645 [positive regulation of gamma-delta T cell activation]
GO:0046658 [anchored component of plasma membrane]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050700 [CARD domain binding]
GO:0050727 [regulation of inflammatory response]
GO:0050871 [positive regulation of B cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0051770 [positive regulation of nitric-oxide synthase biosynthetic process]
GO:0051879 [Hsp90 protein binding]
GO:0060585 [positive regulation of prostaglandin-endoperoxide synthase activity]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071225 [cellular response to muramyl dipeptide]
GO:1900017 [positive regulation of cytokine production involved in inflammatory response]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1902523 [positive regulation of protein K63-linked ubiquitination]
GO:2000110 [negative regulation of macrophage apoptotic process]
GO:2000363 [positive regulation of prostaglandin-E synthase activity]
Show all
1013 aa
112.5 kDa
No 0

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  • PRESS ROOM
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The Human Protein Atlas

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.