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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes FDA approved drug targets Human disease related genes Nuclear receptors Plasma proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
q12
Chromosome location (bp)
67544021 - 67730619
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
AR-201
AR-203
AR-204
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Nuclear receptors Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of male genital organs Congenital malformations Congenital malformations of genital organs Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001091 [RNA polymerase II general transcription initiation factor binding] GO:0001225 [RNA polymerase II transcription coactivator binding] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001701 [in utero embryonic development] GO:0003073 [regulation of systemic arterial blood pressure] GO:0003382 [epithelial cell morphogenesis] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0004879 [nuclear receptor activity] GO:0005102 [signaling receptor binding] GO:0005496 [steroid binding] GO:0005497 [androgen binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0007283 [spermatogenesis] GO:0007338 [single fertilization] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008285 [negative regulation of cell population proliferation] GO:0008289 [lipid binding] GO:0008584 [male gonad development] GO:0009566 [fertilization] GO:0009987 [cellular process] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0016579 [protein deubiquitination] GO:0016607 [nuclear speck] GO:0019102 [male somatic sex determination] GO:0019899 [enzyme binding] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0032991 [protein-containing complex] GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway] GO:0033327 [Leydig cell differentiation] GO:0035264 [multicellular organism growth] GO:0042327 [positive regulation of phosphorylation] GO:0043410 [positive regulation of MAPK cascade] GO:0043565 [sequence-specific DNA binding] GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway] GO:0045597 [positive regulation of cell differentiation] GO:0045720 [negative regulation of integrin biosynthetic process] GO:0045726 [positive regulation of integrin biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0045945 [positive regulation of transcription by RNA polymerase III] GO:0046872 [metal ion binding] GO:0048608 [reproductive structure development] GO:0048638 [regulation of developmental growth] GO:0048645 [animal organ formation] GO:0048808 [male genitalia morphogenesis] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051117 [ATPase binding] GO:0060520 [activation of prostate induction by androgen receptor signaling pathway] GO:0060571 [morphogenesis of an epithelial fold] GO:0060599 [lateral sprouting involved in mammary gland duct morphogenesis] GO:0060685 [regulation of prostatic bud formation] GO:0060736 [prostate gland growth] GO:0060740 [prostate gland epithelium morphogenesis] GO:0060742 [epithelial cell differentiation involved in prostate gland development] GO:0060748 [tertiary branching involved in mammary gland duct morphogenesis] GO:0060749 [mammary gland alveolus development] GO:0060769 [positive regulation of epithelial cell proliferation involved in prostate gland development] GO:0061458 [reproductive system development] GO:0070974 [POU domain binding] GO:0071383 [cellular response to steroid hormone stimulus] GO:0071391 [cellular response to estrogen stimulus] GO:0071394 [cellular response to testosterone stimulus] GO:0072520 [seminiferous tubule development] GO:1903076 [regulation of protein localization to plasma membrane] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Cancers of male genital organs Congenital malformations Congenital malformations of genital organs Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of male genital organs Congenital malformations Congenital malformations of genital organs Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001091 [RNA polymerase II general transcription initiation factor binding] GO:0001225 [RNA polymerase II transcription coactivator binding] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0004879 [nuclear receptor activity] GO:0005102 [signaling receptor binding] GO:0005496 [steroid binding] GO:0005497 [androgen binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008285 [negative regulation of cell population proliferation] GO:0008289 [lipid binding] GO:0008584 [male gonad development] GO:0010628 [positive regulation of gene expression] GO:0016579 [protein deubiquitination] GO:0016607 [nuclear speck] GO:0019899 [enzyme binding] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0032991 [protein-containing complex] GO:0042327 [positive regulation of phosphorylation] GO:0043565 [sequence-specific DNA binding] GO:0045597 [positive regulation of cell differentiation] GO:0045720 [negative regulation of integrin biosynthetic process] GO:0045726 [positive regulation of integrin biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0045945 [positive regulation of transcription by RNA polymerase III] GO:0046872 [metal ion binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051117 [ATPase binding] GO:0071383 [cellular response to steroid hormone stimulus] GO:0071391 [cellular response to estrogen stimulus] GO:0071394 [cellular response to testosterone stimulus] GO:1903076 [regulation of protein localization to plasma membrane] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
