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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:54.9 nTPM
HPA:54.9 nTPM
GTEx:42.1 nTPM
FANTOM5:301.1 Scaled Tags Per Million
Pig:54.2 nTPM
Mouse:71.1 nTPM
Allen mouse:7.0 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 54.9
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 37.5
1870 Female, age 42, unknown 49.3
2411 Female, age 72, unknown 48.4
1833 Male, age 53, unknown 47.8
1830 Male, age 51, unknown 46.0
2219 Male, age 76, both hemispheres 39.3
2828 Female, age 72, unknown 32.6
1827 Male, age 72, unknown 32.4
2019 Male, age 18, unknown 27.3
2666 Male, age 74, left hemisphere 26.7
2586 Male, age 75, left hemisphere 25.1
Dorsal raphe nucleus
nTPM: 46.1
2750 Male, age 76, both hemispheres 66.0
2047 Male, age 72, unknown 45.3
2298 Female, age 72, unknown 42.0
2016 Female, age 72, unknown 39.6
1828 Male, age 53, unknown 37.4
Inferior colliculus
nTPM: 36.1
2849 Male, age 72, unknown 43.9
1848 Female, age 42, unknown 40.0
2097 Female, age 72, unknown 32.2
1890 Male, age 53, unknown 28.3
Median raphe nucleus
nTPM: 54.9
2220 Male, age 76, midline 54.9
Pedunculopontine tegmental nucleus
nTPM: 41.2
2334 Male, age 80, both hemispheres 45.5
1921 Female, age 85, both hemispheres 40.0
2338 Male, age 61, both hemispheres 38.0
Periaquaductal grey, anterior
nTPM: 31.5
1947 Male, age 18, unknown 40.9
2502 Female, age 75, unknown 28.0
1795 Male, age 51, unknown 25.7
Periaquaductal grey, dorsal
nTPM: 33.4
2464 Female, age 72, unknown 36.1
1840 Male, age 53, unknown 34.4
2850 Male, age 76, both hemispheres 33.0
1831 Male, age 72, unknown 30.1
Periaquaductal grey, lateral
nTPM: 30.2
2053 Male, age 18, unknown 32.4
2272 Male, age 74, both hemispheres 29.2
2140 Male, age 76, both hemispheres 28.8
Pretectal area
nTPM: 28.9
2825 Male, age 18, unknown 38.7
2224 Female, age 72, unknown 38.3
2316 Male, age 76, right hemisphere 37.5
2667 Female, age 75, unknown 33.8
2273 Male, age 74, both hemispheres 30.5
2407 Male, age 75, both hemispheres 28.5
1815 Male, age 53, unknown 27.7
1817 Female, age 42, unknown 24.8
1944 Female, age 72, unknown 19.9
2007 Male, age 72, unknown 19.6
1816 Male, age 51, unknown 17.9
Red nucleus
nTPM: 43.6
1821 Female, age 72, unknown 64.6
1865 Male, age 51, unknown 51.0
1904 Male, age 53, unknown 49.5
1954 Female, age 42, unknown 49.4
2769 Male, age 72, unknown 47.5
2227 Male, age 72, unknown 46.8
2823 Male, age 76, right hemisphere 44.6
2503 Female, age 72, unknown 40.2
2725 Female, age 75, unknown 39.0
2588 Male, age 74, left hemisphere 32.9
2785 Male, age 18, unknown 29.2
2584 Male, age 75, left hemisphere 29.0
Substantia nigra
nTPM: 36.2
2699 Male, age 18, unknown 47.3
1851 Male, age 51, unknown 40.0
2241 Male, age 72, unknown 39.7
1941 Male, age 53, unknown 39.6
2409 Female, age 72, unknown 37.3
1916 Female, age 42, unknown 35.3
1889 Female, age 72, unknown 34.4
2590 Female, age 75, unknown 31.8
2583 Male, age 75, right hemisphere 31.6
2665 Male, age 74, both hemispheres 25.2
Superior colliculus
nTPM: 33.2
1895 Male, age 76, right hemisphere 50.6
1839 Male, age 51, unknown 41.5
1913 Female, age 42, unknown 39.2
2587 Male, age 74, left hemisphere 37.3
2668 Female, age 75, unknown 34.7
1995 Male, age 72, unknown 33.5
1796 Male, age 53, unknown 28.7
2261 Male, age 18, unknown 23.4
2087 Female, age 72, unknown 21.9
2664 Male, age 75, both hemispheres 21.2
Ventral tegmental area
nTPM: 44.0
2218 Male, age 76, both hemispheres 50.8
2410 Female, age 72, unknown 46.3
2223 Female, age 72, unknown 44.5
1915 Female, age 42, unknown 42.2
2021 Male, age 53, unknown 41.8
1942 Male, age 51, unknown 38.5

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 42.1
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 42.1
Samples: 139

Max nTPM: 127.5
Min nTPM: 15.8
Std nTPM: 18.5
Median nTPM: 37.2
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 127.5
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 106.0
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 97.7
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 96.4
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 96.3
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 96.2
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 87.2
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 73.6
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 72.4
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 68.4
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 68.2
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 67.8
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 65.1
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 64.0
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 62.7
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 60.8
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 59.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 58.9
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 58.2
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 58.0
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 57.6
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 57.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 56.7
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 55.4
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 55.2
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 54.1
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 52.4
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 52.4
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 51.8
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 51.4
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 50.9
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 50.7
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 50.3
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 49.7
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 49.6
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 49.0
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 48.5
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 48.3
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 48.2
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 46.5
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 46.4
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 46.4
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 46.1
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 46.0
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 45.9
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 45.0
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 44.5
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 43.4
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 43.3
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 43.1
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 43.1
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 42.5
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 42.2
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 42.0
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 41.8
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 41.4
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 41.3
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 40.8
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 40.3
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 40.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 39.5
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 39.3
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 38.9
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 38.6
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 38.5
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 38.4
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 38.2
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 37.9
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 37.4
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 37.2
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 37.1
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 37.1
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 37.1
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 36.7
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 36.5
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 36.2
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 36.2
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 36.1
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 36.0
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 35.3
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 35.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 35.0
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 34.9
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 33.8
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 33.8
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 33.6
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 33.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 33.1
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 33.1
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 33.1
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 32.9
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 32.9
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 32.3
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 31.9
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 31.8
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 31.5
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 31.2
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 31.2
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 31.1
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 30.8
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 30.4
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 30.2
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 30.1
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 30.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 29.7
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 29.5
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 29.0
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 29.0
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 28.7
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 28.4
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 28.4
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 28.3
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 28.2
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 27.5
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 27.2
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 27.2
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 27.1
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 26.9
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 26.5
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 26.3
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 25.8
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 25.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 25.8
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 25.8
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 25.1
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 25.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 24.5
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 24.4
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 24.2
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 24.2
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 24.1
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 21.2
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 21.1
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 21.1
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 20.7
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 19.7
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 17.6
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 16.6
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 15.8
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 301.1
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 301.1
FF:10158-103A5 76 years, female 301.1

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 54.2
Pig sample Sample description nTPM
Midbrain
nTPM: 35.6
Samples: 4

Max nTPM: 46.1
Min nTPM: 21.2
Sample A Female 29.4
Sample B Female 46.1
Sample C Male 21.2
Sample D Male 45.6
Periaqueductal gray
nTPM: 40.6
Samples: 3

Max nTPM: 43.9
Min nTPM: 38.2
Sample B Female 39.7
Sample C Male 43.9
Sample D Male 38.2
Substantia nigra
nTPM: 41.3
Samples: 4

Max nTPM: 51.5
Min nTPM: 33.6
Sample A Female 45.9
Sample B Female 51.5
Sample C Male 34.2
Sample D Male 33.6
Superior colliculi
nTPM: 54.2
Samples: 4

Max nTPM: 91.3
Min nTPM: 21.2
Sample A Female 62.9
Sample B Female 91.3
Sample C Male 21.2
Sample D Male 41.5

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 71.1
Mouse sample Sample description nTPM
Midbrain
nTPM: 71.1
Samples: 4

Max nTPM: 76.4
Min nTPM: 63.7
Sample A Male 63.7
Sample B Male 74.5
Sample C Female 76.4
Sample D Female 69.9

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 7.0
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 7.0
130155 Antisense, RP_040407_01_F11, Mouse strain C57BL/6J (56 days, male) 7.7
70928271 Antisense, RP_050725_02_C06, Mouse strain C57BL/6J (56 days, male) 6.4

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