We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes FDA approved drug targets Human disease related genes Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
18
Cytoband
q21.33
Chromosome location (bp)
63123346 - 63320128
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
BCL2-201
BCL2-202
BCL2-203
BCL2-204
BCL2-208
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination] GO:0001836 [release of cytochrome c from mitochondria] GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006915 [apoptotic process] GO:0006959 [humoral immune response] GO:0006974 [cellular response to DNA damage stimulus] GO:0007565 [female pregnancy] GO:0008284 [positive regulation of cell population proliferation] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0009314 [response to radiation] GO:0009636 [response to toxic substance] GO:0010039 [response to iron ion] GO:0010507 [negative regulation of autophagy] GO:0015267 [channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016248 [channel inhibitor activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0022898 [regulation of transmembrane transporter activity] GO:0030307 [positive regulation of cell growth] GO:0030890 [positive regulation of B cell proliferation] GO:0031625 [ubiquitin protein ligase binding] GO:0031965 [nuclear membrane] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032848 [negative regulation of cellular pH reduction] GO:0032991 [protein-containing complex] GO:0034097 [response to cytokine] GO:0035094 [response to nicotine] GO:0042100 [B cell proliferation] GO:0042493 [response to drug] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0046902 [regulation of mitochondrial membrane permeability] GO:0046930 [pore complex] GO:0046982 [protein heterodimerization activity] GO:0050853 [B cell receptor signaling pathway] GO:0051402 [neuron apoptotic process] GO:0051434 [BH3 domain binding] GO:0051607 [defense response to virus] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0051924 [regulation of calcium ion transport] GO:0055085 [transmembrane transport] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070491 [repressing transcription factor binding] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:2000811 [negative regulation of anoikis] GO:2001234 [negative regulation of apoptotic signaling pathway] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination] GO:0000902 [cell morphogenesis] GO:0001503 [ossification] GO:0001541 [ovarian follicle development] GO:0001656 [metanephros development] GO:0001657 [ureteric bud development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001662 [behavioral fear response] GO:0001776 [leukocyte homeostasis] GO:0001782 [B cell homeostasis] GO:0001822 [kidney development] GO:0001836 [release of cytochrome c from mitochondria] GO:0001952 [regulation of cell-matrix adhesion] GO:0002020 [protease binding] GO:0002260 [lymphocyte homeostasis] GO:0002320 [lymphoid progenitor cell differentiation] GO:0002326 [B cell lineage commitment] GO:0002360 [T cell lineage commitment] GO:0002520 [immune system development] GO:0002931 [response to ischemia] GO:0003014 [renal system process] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006470 [protein dephosphorylation] GO:0006582 [melanin metabolic process] GO:0006808 [regulation of nitrogen utilization] GO:0006874 [cellular calcium ion homeostasis] GO:0006915 [apoptotic process] GO:0006959 [humoral immune response] GO:0006974 [cellular response to DNA damage stimulus] GO:0006979 [response to oxidative stress] GO:0007015 [actin filament organization] GO:0007409 [axonogenesis] GO:0007565 [female pregnancy] GO:0007569 [cell aging] GO:0008134 [transcription factor binding] GO:0008283 [cell population proliferation] GO:0008284 [positive regulation of cell population proliferation] GO:0008285 [negative regulation of cell population proliferation] GO:0008584 [male gonad development] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0008637 [apoptotic mitochondrial changes] GO:0009314 [response to radiation] GO:0009636 [response to toxic substance] GO:0009791 [post-embryonic development] GO:0009887 [animal organ morphogenesis] GO:0010039 [response to iron ion] GO:0010224 [response to UV-B] GO:0010332 [response to gamma radiation] GO:0010468 [regulation of gene expression] GO:0010506 [regulation of autophagy] GO:0010507 [negative regulation of autophagy] GO:0010523 [negative regulation of calcium ion transport into cytosol] GO:0010559 [regulation of glycoprotein biosynthetic process] GO:0014031 [mesenchymal cell development] GO:0014042 [positive regulation of neuron maturation] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0015267 [channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016248 [channel inhibitor activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019903 [protein phosphatase binding] GO:0021747 [cochlear nucleus development] GO:0022612 [gland morphogenesis] GO:0022898 [regulation of transmembrane transporter activity] GO:0030097 [hemopoiesis] GO:0030183 [B cell differentiation] GO:0030217 [T cell differentiation] GO:0030279 [negative regulation of ossification] GO:0030307 [positive regulation of cell growth] GO:0030308 [negative regulation of cell growth] GO:0030318 [melanocyte differentiation] GO:0030336 [negative regulation of cell migration] GO:0030890 [positive regulation of B cell proliferation] GO:0031069 [hair follicle morphogenesis] GO:0031103 [axon regeneration] GO:0031625 [ubiquitin protein ligase binding] GO:0031647 [regulation of protein stability] GO:0031965 [nuclear membrane] GO:0031966 [mitochondrial membrane] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032835 [glomerulus development] GO:0032848 [negative regulation of cellular pH reduction] GO:0032880 [regulation of protein localization] GO:0032991 [protein-containing complex] GO:0033033 [negative regulation of myeloid cell apoptotic process] GO:0033077 [T cell differentiation in thymus] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033689 [negative regulation of osteoblast proliferation] GO:0034097 [response to cytokine] GO:0035094 [response to nicotine] GO:0035265 [organ growth] GO:0040008 [regulation of growth] GO:0040018 [positive regulation of multicellular organism growth] GO:0042100 [B cell proliferation] GO:0042149 [cellular response to glucose starvation] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043029 [T cell homeostasis] GO:0043066 [negative regulation of apoptotic process] GO:0043067 [regulation of programmed cell death] GO:0043085 [positive regulation of catalytic activity] GO:0043209 [myelin sheath] GO:0043375 [CD8-positive, alpha-beta T cell lineage commitment] GO:0043473 [pigmentation] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0043583 [ear development] GO:0045069 [regulation of viral genome replication] GO:0045636 [positive regulation of melanocyte differentiation] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046671 [negative regulation of retinal cell programmed cell death] GO:0046902 [regulation of mitochondrial membrane permeability] GO:0046930 [pore complex] GO:0046982 [protein heterodimerization activity] GO:0048041 [focal adhesion assembly] GO:0048066 [developmental pigmentation] GO:0048070 [regulation of developmental pigmentation] GO:0048087 [positive regulation of developmental pigmentation] GO:0048536 [spleen development] GO:0048538 [thymus development] GO:0048545 [response to steroid hormone] GO:0048546 [digestive tract morphogenesis] GO:0048589 [developmental growth] GO:0048599 [oocyte development] GO:0048743 [positive regulation of skeletal muscle fiber development] GO:0048753 [pigment granule organization] GO:0048873 [homeostasis of number of cells within a tissue] GO:0050790 [regulation of catalytic activity] GO:0050853 [B cell receptor signaling pathway] GO:0051384 [response to glucocorticoid] GO:0051402 [neuron apoptotic process] GO:0051434 [BH3 domain binding] GO:0051607 [defense response to virus] GO:0051721 [protein phosphatase 2A binding] GO:0051726 [regulation of cell cycle] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0051924 [regulation of calcium ion transport] GO:0055085 [transmembrane transport] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070491 [repressing transcription factor binding] GO:0071310 [cellular response to organic substance] GO:0071456 [cellular response to hypoxia] GO:0072593 [reactive oxygen species metabolic process] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:0098609 [cell-cell adhesion] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] GO:2000378 [negative regulation of reactive oxygen species metabolic process] GO:2000811 [negative regulation of anoikis] GO:2001234 [negative regulation of apoptotic signaling pathway] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Head and neck cancers Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination] GO:0001836 [release of cytochrome c from mitochondria] GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006915 [apoptotic process] GO:0006959 [humoral immune response] GO:0006974 [cellular response to DNA damage stimulus] GO:0007565 [female pregnancy] GO:0008284 [positive regulation of cell population proliferation] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0009314 [response to radiation] GO:0009636 [response to toxic substance] GO:0010039 [response to iron ion] GO:0010507 [negative regulation of autophagy] GO:0015267 [channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016248 [channel inhibitor activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0022898 [regulation of transmembrane transporter activity] GO:0030307 [positive regulation of cell growth] GO:0030890 [positive regulation of B cell proliferation] GO:0031625 [ubiquitin protein ligase binding] GO:0031965 [nuclear membrane] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032848 [negative regulation of cellular pH reduction] GO:0032991 [protein-containing complex] GO:0034097 [response to cytokine] GO:0035094 [response to nicotine] GO:0042100 [B cell proliferation] GO:0042493 [response to drug] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0046902 [regulation of mitochondrial membrane permeability] GO:0046930 [pore complex] GO:0046982 [protein heterodimerization activity] GO:0050853 [B cell receptor signaling pathway] GO:0051402 [neuron apoptotic process] GO:0051434 [BH3 domain binding] GO:0051607 [defense response to virus] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0051924 [regulation of calcium ion transport] GO:0055085 [transmembrane transport] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070491 [repressing transcription factor binding] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:2000811 [negative regulation of anoikis] GO:2001234 [negative regulation of apoptotic signaling pathway] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)