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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q23.31
Chromosome location (bp)
87863625 - 87971930
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
PTEN-201
PTEN-203
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P60484 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN F6KD01 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
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Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis] GO:0001933 [negative regulation of protein phosphorylation] GO:0002902 [regulation of B cell apoptotic process] GO:0004438 [phosphatidylinositol-3-phosphatase activity] GO:0004721 [phosphoprotein phosphatase activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006470 [protein dephosphorylation] GO:0006629 [lipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0006915 [apoptotic process] GO:0007270 [neuron-neuron synaptic transmission] GO:0007399 [nervous system development] GO:0007416 [synapse assembly] GO:0007417 [central nervous system development] GO:0007507 [heart development] GO:0007568 [aging] GO:0007584 [response to nutrient] GO:0007611 [learning or memory] GO:0007613 [memory] GO:0007626 [locomotory behavior] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0008284 [positive regulation of cell population proliferation] GO:0008285 [negative regulation of cell population proliferation] GO:0008289 [lipid binding] GO:0009749 [response to glucose] GO:0009898 [cytoplasmic side of plasma membrane] GO:0010033 [response to organic substance] GO:0010035 [response to inorganic substance] GO:0010043 [response to zinc ion] GO:0010628 [positive regulation of gene expression] GO:0010666 [positive regulation of cardiac muscle cell apoptotic process] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0010975 [regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0010997 [anaphase-promoting complex binding] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling] GO:0014070 [response to organic cyclic compound] GO:0014823 [response to activity] GO:0016311 [dephosphorylation] GO:0016314 [phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016324 [apical plasma membrane] GO:0016477 [cell migration] GO:0016579 [protein deubiquitination] GO:0016605 [PML body] GO:0016787 [hydrolase activity] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0021542 [dentate gyrus development] GO:0021955 [central nervous system neuron axonogenesis] GO:0030165 [PDZ domain binding] GO:0030336 [negative regulation of cell migration] GO:0030534 [adult behavior] GO:0031175 [neuron projection development] GO:0031642 [negative regulation of myelination] GO:0031647 [regulation of protein stability] GO:0032228 [regulation of synaptic transmission, GABAergic] GO:0032286 [central nervous system myelin maintenance] GO:0032355 [response to estradiol] GO:0032535 [regulation of cellular component size] GO:0032869 [cellular response to insulin stimulus] GO:0033032 [regulation of myeloid cell apoptotic process] GO:0033137 [negative regulation of peptidyl-serine phosphorylation] GO:0033198 [response to ATP] GO:0033555 [multicellular organismal response to stress] GO:0035176 [social behavior] GO:0035255 [ionotropic glutamate receptor binding] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0035749 [myelin sheath adaxonal region] GO:0036294 [cellular response to decreased oxygen levels] GO:0042493 [response to drug] GO:0042711 [maternal behavior] GO:0042802 [identical protein binding] GO:0042995 [cell projection] GO:0043005 [neuron projection] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043197 [dendritic spine] GO:0043220 [Schmidt-Lanterman incisure] GO:0043491 [protein kinase B signaling] GO:0043542 [endothelial cell migration] GO:0043647 [inositol phosphate metabolic process] GO:0044320 [cellular response to leptin stimulus] GO:0045211 [postsynaptic membrane] GO:0045471 [response to ethanol] GO:0045475 [locomotor rhythm] GO:0045666 [positive regulation of neuron differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045792 [negative regulation of cell size] GO:0046621 [negative regulation of organ growth] GO:0046685 [response to arsenic-containing substance] GO:0046855 [inositol phosphate dephosphorylation] GO:0046856 [phosphatidylinositol dephosphorylation] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048679 [regulation of axon regeneration] GO:0048681 [negative regulation of axon regeneration] GO:0048738 [cardiac muscle tissue development] GO:0048853 [forebrain morphogenesis] GO:0048854 [brain morphogenesis] GO:0048870 [cell motility] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0050765 [negative regulation of phagocytosis] GO:0050771 [negative regulation of axonogenesis] GO:0050821 [protein stabilization] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051548 [negative regulation of keratinocyte migration] GO:0051717 [inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity] GO:0051726 [regulation of cell cycle] GO:0051800 [phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051896 [regulation of protein kinase B signaling] GO:0051898 [negative regulation of protein kinase B signaling] GO:0060024 [rhythmic synaptic transmission] GO:0060044 [negative regulation of cardiac muscle cell proliferation] GO:0060070 [canonical Wnt signaling pathway] GO:0060074 [synapse maturation] GO:0060134 [prepulse inhibition] GO:0060179 [male mating behavior] GO:0060291 [long-term synaptic potentiation] GO:0060292 [long-term synaptic depression] GO:0060341 [regulation of cellular localization] GO:0060736 [prostate gland growth] GO:0060997 [dendritic spine morphogenesis] GO:0061002 [negative regulation of dendritic spine morphogenesis] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071257 [cellular response to electrical stimulus] GO:0071361 [cellular response to ethanol] GO:0071456 [cellular response to hypoxia] GO:0090071 [negative regulation of ribosome biogenesis] GO:0090344 [negative regulation of cell aging] GO:0090394 [negative regulation of excitatory postsynaptic potential] GO:0097105 [presynaptic membrane assembly] GO:0097107 [postsynaptic density assembly] GO:0099524 [postsynaptic cytosol] GO:0106306 [] GO:0106307 [] GO:1901017 [negative regulation of potassium ion transmembrane transporter activity] GO:1902807 [negative regulation of cell cycle G1/S phase transition] GO:1903690 [negative regulation of wound healing, spreading of epidermal cells] GO:1903984 [positive regulation of TRAIL-activated apoptotic signaling pathway] GO:1904668 [positive regulation of ubiquitin protein ligase activity] GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990314 [cellular response to insulin-like growth factor stimulus] GO:1990381 [ubiquitin-specific protease binding] GO:1990782 [protein tyrosine kinase binding] GO:2000060 [positive regulation of ubiquitin-dependent protein catabolic process] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] GO:2000272 [negative regulation of signaling receptor activity] GO:2000463 [positive regulation of excitatory postsynaptic potential] GO:2000808 [negative regulation of synaptic vesicle clustering] GO:2001235 [positive regulation of apoptotic signaling pathway]
A0A087X033 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)