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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
CD markers Disease related genes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
p13
Chromosome location (bp)
4686350 - 4701590
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
PRNP-201
PRNP-202
PRNP-203
PRNP-204
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P04156 [Direct mapping] Major prion protein Q53YK7 [Target identity:100%; Query identity:100%] Major prion protein
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CD markers Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001540 [amyloid-beta binding] GO:0001933 [negative regulation of protein phosphorylation] GO:0002020 [protease binding] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006878 [cellular copper ion homeostasis] GO:0006979 [response to oxidative stress] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007611 [learning or memory] GO:0007616 [long-term memory] GO:0008017 [microtubule binding] GO:0009986 [cell surface] GO:0010951 [negative regulation of endopeptidase activity] GO:0010955 [negative regulation of protein processing] GO:0014069 [postsynaptic density] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016234 [inclusion body] GO:0019828 [aspartic-type endopeptidase inhibitor activity] GO:0019898 [extrinsic component of membrane] GO:0030425 [dendrite] GO:0031225 [anchored component of membrane] GO:0031362 [anchored component of external side of plasma membrane] GO:0031648 [protein destabilization] GO:0031802 [type 5 metabotropic glutamate receptor binding] GO:0031965 [nuclear membrane] GO:0032689 [negative regulation of interferon-gamma production] GO:0032700 [negative regulation of interleukin-17 production] GO:0032703 [negative regulation of interleukin-2 production] GO:0035584 [calcium-mediated signaling using intracellular calcium source] GO:0038023 [signaling receptor activity] GO:0042802 [identical protein binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043433 [negative regulation of DNA-binding transcription factor activity] GO:0043525 [positive regulation of neuron apoptotic process] GO:0044877 [protein-containing complex binding] GO:0045121 [membrane raft] GO:0046007 [negative regulation of activated T cell proliferation] GO:0046872 [metal ion binding] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050860 [negative regulation of T cell receptor signaling pathway] GO:0051260 [protein homooligomerization] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070062 [extracellular exosome] GO:0070885 [negative regulation of calcineurin-NFAT signaling cascade] GO:0071280 [cellular response to copper ion] GO:0090314 [positive regulation of protein targeting to membrane] GO:0090647 [modulation of age-related behavioral decline] GO:0097062 [dendritic spine maintenance] GO:0098794 [postsynapse] GO:1900449 [regulation of glutamate receptor signaling pathway] GO:1901216 [positive regulation of neuron death] GO:1902430 [negative regulation of amyloid-beta formation] GO:1902938 [regulation of intracellular calcium activated chloride channel activity] GO:1902951 [negative regulation of dendritic spine maintenance] GO:1902992 [negative regulation of amyloid precursor protein catabolic process] GO:1903136 [cuprous ion binding] GO:1904645 [response to amyloid-beta] GO:1904646 [cellular response to amyloid-beta] GO:1905664 [regulation of calcium ion import across plasma membrane] GO:1990535 [neuron projection maintenance]
The Human Protein Atlas project is funded
