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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
PRIMARY MOUSE DATA
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

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No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:42.2 nTPM
HPA:42.2 nTPM
GTEx:67.4 nTPM
FANTOM5:1.7 Scaled Tags Per Million
Pig:150.5 nTPM
Mouse:216.1 nTPM
Allen mouse:10.7 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 42.2
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 26.7
1827 Male, age 72, unknown 48.4
1870 Female, age 42, unknown 35.2
2828 Female, age 72, unknown 33.8
2411 Female, age 72, unknown 33.4
2586 Male, age 75, left hemisphere 29.5
2219 Male, age 76, both hemispheres 22.7
2666 Male, age 74, left hemisphere 20.7
1830 Male, age 51, unknown 18.9
1833 Male, age 53, unknown 17.0
2019 Male, age 18, unknown 7.2
Dorsal raphe nucleus
nTPM: 19.7
2298 Female, age 72, unknown 29.5
2750 Male, age 76, both hemispheres 22.7
2016 Female, age 72, unknown 20.6
2047 Male, age 72, unknown 15.3
1828 Male, age 53, unknown 10.6
Inferior colliculus
nTPM: 21.9
2849 Male, age 72, unknown 28.6
1848 Female, age 42, unknown 23.9
2097 Female, age 72, unknown 19.7
1890 Male, age 53, unknown 15.4
Median raphe nucleus
nTPM: 26.4
2220 Male, age 76, midline 26.4
Pedunculopontine tegmental nucleus
nTPM: 42.2
1921 Female, age 85, both hemispheres 56.0
2338 Male, age 61, both hemispheres 38.4
2334 Male, age 80, both hemispheres 32.3
Periaquaductal grey, anterior
nTPM: 33.7
1795 Male, age 51, unknown 52.9
2502 Female, age 75, unknown 32.8
1947 Male, age 18, unknown 15.2
Periaquaductal grey, dorsal
nTPM: 32.1
2850 Male, age 76, both hemispheres 37.7
1831 Male, age 72, unknown 34.9
1840 Male, age 53, unknown 32.6
2464 Female, age 72, unknown 23.3
Periaquaductal grey, lateral
nTPM: 41.7
2053 Male, age 18, unknown 75.0
2140 Male, age 76, both hemispheres 31.3
2272 Male, age 74, both hemispheres 18.9
Pretectal area
nTPM: 30.0
2224 Female, age 72, unknown 91.3
2825 Male, age 18, unknown 71.4
2316 Male, age 76, right hemisphere 28.5
2667 Female, age 75, unknown 27.8
1816 Male, age 51, unknown 19.1
2407 Male, age 75, both hemispheres 18.6
2007 Male, age 72, unknown 17.0
1815 Male, age 53, unknown 15.5
2273 Male, age 74, both hemispheres 15.5
1944 Female, age 72, unknown 15.1
1817 Female, age 42, unknown 10.5
Red nucleus
nTPM: 9.7
2584 Male, age 75, left hemisphere 25.3
2227 Male, age 72, unknown 11.2
2769 Male, age 72, unknown 10.9
1821 Female, age 72, unknown 10.7
2725 Female, age 75, unknown 9.6
2823 Male, age 76, right hemisphere 8.7
1865 Male, age 51, unknown 7.5
1954 Female, age 42, unknown 7.4
2503 Female, age 72, unknown 6.8
2588 Male, age 74, left hemisphere 6.7
1904 Male, age 53, unknown 6.5
2785 Male, age 18, unknown 5.5
Substantia nigra
nTPM: 13.4
1941 Male, age 53, unknown 35.0
1889 Female, age 72, unknown 23.6
2241 Male, age 72, unknown 18.3
2590 Female, age 75, unknown 11.2
2699 Male, age 18, unknown 8.2
2583 Male, age 75, right hemisphere 8.0
1851 Male, age 51, unknown 7.8
2665 Male, age 74, both hemispheres 7.8
1916 Female, age 42, unknown 7.7
2409 Female, age 72, unknown 5.9
Superior colliculus
nTPM: 21.0
2261 Male, age 18, unknown 47.8
1839 Male, age 51, unknown 27.3
1895 Male, age 76, right hemisphere 27.0
1796 Male, age 53, unknown 26.1
2587 Male, age 74, left hemisphere 21.8
2664 Male, age 75, both hemispheres 21.5
1913 Female, age 42, unknown 13.3
2668 Female, age 75, unknown 11.4
2087 Female, age 72, unknown 9.5
1995 Male, age 72, unknown 4.3
Ventral tegmental area
nTPM: 20.8
1915 Female, age 42, unknown 31.6
2021 Male, age 53, unknown 28.1
1942 Male, age 51, unknown 18.7
2218 Male, age 76, both hemispheres 18.4
2223 Female, age 72, unknown 14.4
2410 Female, age 72, unknown 13.4

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 67.4
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 67.4
Samples: 139

Max nTPM: 968.6
Min nTPM: 1.0
Std nTPM: 117.3
Median nTPM: 34.9
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 968.6
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 577.5
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 498.0
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 418.8
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 318.5
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 284.9
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 253.3
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 245.6
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 227.9
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 196.9
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 192.7
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 192.4
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 187.7
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 161.2
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 156.8
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 139.4
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 135.3
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 124.6
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 123.2
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 121.5
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 121.0
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 116.1
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 108.7
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 103.6
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 95.6
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 90.5
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 87.9
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 85.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 78.7
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 77.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 71.5
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 65.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 63.2
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 63.2
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 62.5
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 58.8
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 57.5
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 56.8
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 56.7
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 56.1
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 53.7
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 52.2
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 51.7
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 49.8
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 49.3
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 48.2
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 47.6
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 47.3
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 46.7
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 46.3
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 45.9
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 45.8
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 45.6
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 45.4
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 43.8
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 43.8
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 43.7
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 43.0
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 42.5
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 41.5
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 40.5
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 39.8
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 39.5
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 39.5
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 39.4
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 38.9
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 38.7
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 37.4
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 36.7
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 34.9
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 34.6
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 34.0
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 32.8
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 32.2
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 31.7
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 31.6
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 31.5
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 30.8
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 30.7
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 28.5
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 27.6
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 27.2
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 26.4
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 22.2
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 21.5
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 21.3
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 20.9
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 20.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 19.1
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 18.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 18.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 17.8
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 17.6
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 17.4
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 17.4
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 13.8
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 13.2
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 13.1
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 13.0
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 12.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 11.9
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 11.6
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 11.5
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 11.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 11.0
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 10.7
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 10.4
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 9.9
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 9.8
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 9.7
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 9.6
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 9.5
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 8.9
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 8.8
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 8.5
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 8.2
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 7.4
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 6.1
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 5.9
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 5.8
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 5.7
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 5.6
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 5.4
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 5.2
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 4.9
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 4.8
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 4.6
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 4.3
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 4.2
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 4.2
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 3.3
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 2.8
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 2.6
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 2.1
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 1.9
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 1.7
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 1.3
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 1.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 1.0
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MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 1.7
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 1.7
FF:10158-103A5 76 years, female 1.7

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 150.5
Pig sample Sample description nTPM
Midbrain
nTPM: 150.5
Samples: 4

Max nTPM: 295.9
Min nTPM: 20.8
Sample A Female 20.8
Sample B Female 90.6
Sample C Male 295.9
Sample D Male 194.7
Periaqueductal gray
nTPM: 78.0
Samples: 3

Max nTPM: 111.6
Min nTPM: 53.1
Sample B Female 53.1
Sample C Male 111.6
Sample D Male 69.3
Substantia nigra
nTPM: 88.9
Samples: 4

Max nTPM: 166.0
Min nTPM: 10.2
Sample A Female 166.0
Sample B Female 37.8
Sample C Male 141.6
Sample D Male 10.2
Superior colliculi
nTPM: 122.5
Samples: 4

Max nTPM: 196.2
Min nTPM: 71.2
Sample A Female 137.9
Sample B Female 84.5
Sample C Male 196.2
Sample D Male 71.2

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 216.1
Mouse sample Sample description nTPM
Midbrain
nTPM: 216.1
Samples: 4

Max nTPM: 222.4
Min nTPM: 208.6
Sample A Male 221.2
Sample B Male 208.6
Sample C Female 212.3
Sample D Female 222.4

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 10.7
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 10.7
75496134 Antisense, RP_060523_03_F02, Mouse strain C57BL/6J (56 days, male) 12.2
75496136 Antisense, RP_060523_03_H02, Mouse strain C57BL/6J (56 days, male) 12.0
75492322 Antisense, RP_060523_03_F02, Mouse strain C57BL/6J (56 days, male) 11.8
75496135 Antisense, RP_060523_03_G02, Mouse strain C57BL/6J (56 days, male) 11.5
75496133 Antisense, RP_060523_03_E02, Mouse strain C57BL/6J (56 days, male) 11.5
75457438 Antisense, RP_060523_03_E02, Mouse strain C57BL/6J (56 days, male) 11.5
75492430 Antisense, RP_060523_03_H02, Mouse strain C57BL/6J (56 days, male) 11.2
75457440 Antisense, RP_060523_03_G02, Mouse strain C57BL/6J (56 days, male) 10.8
75492224 Antisense, RP_060523_03_E02, Mouse strain C57BL/6J (56 days, male) 10.5
75492428 Antisense, RP_060523_03_G02, Mouse strain C57BL/6J (56 days, male) 9.9
75457439 Antisense, RP_060523_03_F02, Mouse strain C57BL/6J (56 days, male) 9.8
69117422 Antisense, RP_050330_01_B06, Mouse strain C57BL/6J (56 days, male) 9.8
75496400 Antisense, RP_060523_03_H02, Mouse strain C57BL/6J (56 days, male) 9.5
75496390 Antisense, RP_060523_03_G02, Mouse strain C57BL/6J (56 days, male) 9.5
75496380 Antisense, RP_060523_03_F02, Mouse strain C57BL/6J (56 days, male) 9.5
75496370 Antisense, RP_060523_03_E02, Mouse strain C57BL/6J (56 days, male) 9.1
79556662 Antisense, RP_071204_01_B06, Mouse strain C57BL/6J (56 days, male) 7.4

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