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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes RAS pathway related proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q13.1
Chromosome location (bp)
65653597 - 65663090
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001225 [RNA polymerase II transcription coactivator binding] GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006954 [inflammatory response] GO:0006968 [cellular defense response] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell population proliferation] GO:0010033 [response to organic substance] GO:0010224 [response to UV-B] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0031490 [chromatin DNA binding] GO:0031625 [ubiquitin protein ligase binding] GO:0032481 [positive regulation of type I interferon production] GO:0032757 [positive regulation of interleukin-8 production] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0033613 [activating transcription factor binding] GO:0034097 [response to cytokine] GO:0035525 [NF-kappaB p50/p65 complex] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038061 [NIK/NF-kappaB signaling] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042025 [host cell nucleus] GO:0042277 [peptide binding] GO:0042301 [phosphate ion binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042805 [actinin binding] GO:0042826 [histone deacetylase binding] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043620 [regulation of DNA-templated transcription in response to stress] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0047485 [protein N-terminus binding] GO:0050727 [regulation of inflammatory response] GO:0050852 [T cell receptor signaling pathway] GO:0050862 [positive regulation of T cell receptor signaling pathway] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051607 [defense response to virus] GO:0070301 [cellular response to hydrogen peroxide] GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0070491 [repressing transcription factor binding] GO:0070498 [interleukin-1-mediated signaling pathway] GO:0070555 [response to interleukin-1] GO:0071159 [NF-kappaB complex] GO:0071222 [cellular response to lipopolysaccharide] GO:0071223 [cellular response to lipoteichoic acid] GO:0071224 [cellular response to peptidoglycan] GO:0071316 [cellular response to nicotine] GO:0071347 [cellular response to interleukin-1] GO:0071354 [cellular response to interleukin-6] GO:0071356 [cellular response to tumor necrosis factor] GO:1901222 [regulation of NIK/NF-kappaB signaling] GO:1901223 [negative regulation of NIK/NF-kappaB signaling] GO:1901224 [positive regulation of NIK/NF-kappaB signaling] GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus] GO:1902004 [positive regulation of amyloid-beta formation] GO:1902894 [negative regulation of pri-miRNA transcription by RNA polymerase II] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1904385 [cellular response to angiotensin] GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell] GO:2000630 [positive regulation of miRNA metabolic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001225 [RNA polymerase II transcription coactivator binding] GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001889 [liver development] GO:0001942 [hair follicle development] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006117 [acetaldehyde metabolic process] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006952 [defense response] GO:0006954 [inflammatory response] GO:0006968 [cellular defense response] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007568 [aging] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell population proliferation] GO:0009612 [response to mechanical stimulus] GO:0009617 [response to bacterium] GO:0009887 [animal organ morphogenesis] GO:0010033 [response to organic substance] GO:0010035 [response to inorganic substance] GO:0010224 [response to UV-B] GO:0014040 [positive regulation of Schwann cell differentiation] GO:0014070 [response to organic cyclic compound] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0031490 [chromatin DNA binding] GO:0031625 [ubiquitin protein ligase binding] GO:0032481 [positive regulation of type I interferon production] GO:0032495 [response to muramyl dipeptide] GO:0032496 [response to lipopolysaccharide] GO:0032570 [response to progesterone] GO:0032735 [positive regulation of interleukin-12 production] GO:0032757 [positive regulation of interleukin-8 production] GO:0032868 [response to insulin] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0033234 [negative regulation of protein sumoylation] GO:0033590 [response to cobalamin] GO:0033613 [activating transcription factor binding] GO:0034097 [response to cytokine] GO:0035525 [NF-kappaB p50/p65 complex] GO:0035729 [cellular response to hepatocyte growth factor stimulus] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0035994 [response to muscle stretch] GO:0038061 [NIK/NF-kappaB signaling] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042025 [host cell nucleus] GO:0042177 [negative regulation of protein catabolic process] GO:0042277 [peptide binding] GO:0042301 [phosphate ion binding] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042805 [actinin binding] GO:0042826 [histone deacetylase binding] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043200 [response to amino acid] GO:0043278 [response to morphine] GO:0043565 [sequence-specific DNA binding] GO:0043620 [regulation of DNA-templated transcription in response to stress] GO:0044877 [protein-containing complex binding] GO:0045087 [innate immune response] GO:0045202 [synapse] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0047485 [protein N-terminus binding] GO:0050727 [regulation of inflammatory response] GO:0050852 [T cell receptor signaling pathway] GO:0050862 [positive regulation of T cell receptor signaling pathway] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051591 [response to cAMP] GO:0051607 [defense response to virus] GO:0070301 [cellular response to hydrogen peroxide] GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0070491 [repressing transcription factor binding] GO:0070498 [interleukin-1-mediated signaling pathway] GO:0070555 [response to interleukin-1] GO:0071159 [NF-kappaB complex] GO:0071222 [cellular response to lipopolysaccharide] GO:0071223 [cellular response to lipoteichoic acid] GO:0071224 [cellular response to peptidoglycan] GO:0071316 [cellular response to nicotine] GO:0071347 [cellular response to interleukin-1] GO:0071354 [cellular response to interleukin-6] GO:0071356 [cellular response to tumor necrosis factor] GO:0071532 [ankyrin repeat binding] GO:0098978 [glutamatergic synapse] GO:0099527 [postsynapse to nucleus signaling pathway] GO:1901222 [regulation of NIK/NF-kappaB signaling] GO:1901223 [negative regulation of NIK/NF-kappaB signaling] GO:1901224 [positive regulation of NIK/NF-kappaB signaling] GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus] GO:1902004 [positive regulation of amyloid-beta formation] GO:1902894 [negative regulation of pri-miRNA transcription by RNA polymerase II] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1904385 [cellular response to angiotensin] GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell] GO:2000630 [positive regulation of miRNA metabolic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
