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BOK
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PROTEIN STRUCTURE
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

BOK
Synonyms BCL2L9, BOKL, MGC4631
Gene descriptioni

Full gene name according to HGNC.

BCL2 family apoptosis regulator BOK
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Plasma proteins
Transporters
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 2
Cytoband q37.3
Chromosome location (bp) 241551424 - 241574131
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

1
Ensembl ENSG00000176720 (version 103.38)
Entrez gene 666
HGNC HGNC:1087
UniProt Q9UMX3 (UniProt - Evidence at protein level)
neXtProt NX_Q9UMX3
Antibodypedia BOK antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 169

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

Off
On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
BOK-201


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
BOK-201
ENSP00000314132
ENST00000318407
Q9UMX3 [Direct mapping]
Bcl-2-related ovarian killer protein
A0A024R4A8 [Target identity:100%; Query identity:100%]
BCL2-related ovarian killer, isoform CRA_a; Bcl-2-related ovarian killer protein isoform 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005640 [nuclear outer membrane]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005743 [mitochondrial inner membrane]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007420 [brain development]
GO:0008584 [male gonad development]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0010506 [regulation of autophagy]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031966 [mitochondrial membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0033106 [cis-Golgi network membrane]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044877 [protein-containing complex binding]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048709 [oligodendrocyte differentiation]
GO:0051259 [protein complex oligomerization]
GO:0051400 [BH domain binding]
GO:0051402 [neuron apoptotic process]
GO:0051480 [regulation of cytosolic calcium ion concentration]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0055038 [recycling endosome membrane]
GO:0060546 [negative regulation of necroptotic process]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1901029 [negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:1901382 [regulation of chorionic trophoblast cell proliferation]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903899 [positive regulation of PERK-mediated unfolded protein response]
GO:1904708 [regulation of granulosa cell apoptotic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
212 aa
23.3 kDa
No 1

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by the Knut & Alice Wallenberg Foundation.