GENERAL INFORMATIONi
Gene namei GRB2
Synonyms NCKAP2
Gene descriptioni Growth factor receptor bound protein 2
Protein classi Cancer-related genes
Plasma proteins
RAS pathway related proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 17
Cytoband q25.1
Chromosome location (bp) 75318076 - 75405709
Number of transcriptsi 8
Ensembl ENSG00000177885 (version 103.38)
Entrez gene 2885
HGNC HGNC:4566
UniProt P62993 (UniProt - Evidence at protein level)
neXtProt NX_P62993
Antibodypedia GRB2 antibodies


PROTEIN STRUCTUREi

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 57

Experimental


Description: GRB2 (X-ray)

# Chains: 1      # Clinical variants: 0      # Population variants: 57

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

Off
On


PROTEIN BROWSERi
GRB2-201
GRB2-202
GRB2-203
GRB2-204
GRB2-205
GRB2-208
GRB2-209
GRB2-210


PROTEIN INFORMATIONi
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
GRB2-201
ENSP00000317360
ENST00000316615
P62993 [Direct mapping]
Growth factor receptor-bound protein 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001784 [phosphotyrosine residue binding]
GO:0003723 [RNA binding]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0017124 [SH3 domain binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0031295 [T cell costimulation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031623 [receptor internalization]
GO:0035635 [entry of bacterium into host cell]
GO:0035723 [interleukin-15-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0043560 [insulin receptor substrate binding]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046875 [ephrin receptor binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070436 [Grb2-EGFR complex]
GO:0071479 [cellular response to ionizing radiation]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 176 aa
20.6 kDa 		No 0
GRB2-202
ENSP00000339007
ENST00000316804
P62993 [Direct mapping]
Growth factor receptor-bound protein 2
B0LPF3 [Target identity:100%; Query identity:100%]
Adapter protein GRB2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001784 [phosphotyrosine residue binding]
GO:0003723 [RNA binding]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0017124 [SH3 domain binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0031295 [T cell costimulation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031623 [receptor internalization]
GO:0035635 [entry of bacterium into host cell]
GO:0035723 [interleukin-15-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0043560 [insulin receptor substrate binding]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046875 [ephrin receptor binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070436 [Grb2-EGFR complex]
GO:0071479 [cellular response to ionizing radiation]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 217 aa
25.2 kDa 		No 0
GRB2-203
ENSP00000376345
ENST00000392562
P62993 [Direct mapping]
Growth factor receptor-bound protein 2
B0LPF3 [Target identity:100%; Query identity:100%]
Adapter protein GRB2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001784 [phosphotyrosine residue binding]
GO:0003723 [RNA binding]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007568 [aging]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0012506 [vesicle membrane]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0017124 [SH3 domain binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0019904 [protein domain specific binding]
GO:0030154 [cell differentiation]
GO:0030674 [protein-macromolecule adaptor activity]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031295 [T cell costimulation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031623 [receptor internalization]
GO:0032991 [protein-containing complex]
GO:0035635 [entry of bacterium into host cell]
GO:0035723 [interleukin-15-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0043408 [regulation of MAPK cascade]
GO:0043560 [insulin receptor substrate binding]
GO:0044877 [protein-containing complex binding]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046875 [ephrin receptor binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0050900 [leukocyte migration]
GO:0051219 [phosphoprotein binding]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070436 [Grb2-EGFR complex]
GO:0071479 [cellular response to ionizing radiation]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 217 aa
25.2 kDa 		No 0
GRB2-204
ENSP00000376346
ENST00000392563
P62993 [Direct mapping]
Growth factor receptor-bound protein 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001784 [phosphotyrosine residue binding]
GO:0003723 [RNA binding]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0017124 [SH3 domain binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0031295 [T cell costimulation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031623 [receptor internalization]
GO:0035635 [entry of bacterium into host cell]
GO:0035723 [interleukin-15-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0043560 [insulin receptor substrate binding]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046875 [ephrin receptor binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070436 [Grb2-EGFR complex]
GO:0071479 [cellular response to ionizing radiation]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 176 aa
20.6 kDa 		No 0
GRB2-205
ENSP00000376347
ENST00000392564
P62993 [Direct mapping]
Growth factor receptor-bound protein 2
B0LPF3 [Target identity:100%; Query identity:100%]
Adapter protein GRB2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001784 [phosphotyrosine residue binding]
GO:0003723 [RNA binding]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0017124 [SH3 domain binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0031295 [T cell costimulation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031623 [receptor internalization]
GO:0035635 [entry of bacterium into host cell]
GO:0035723 [interleukin-15-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0043560 [insulin receptor substrate binding]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046875 [ephrin receptor binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070436 [Grb2-EGFR complex]
GO:0071479 [cellular response to ionizing radiation]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 217 aa
25.2 kDa 		No 0
GRB2-208
ENSP00000464279
ENST00000578961
J3QRL5 [Direct mapping]
Growth factor receptor-bound protein 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
Show all
 156 aa
17.6 kDa 		No 0
GRB2-209
ENSP00000463525
ENST00000581959
J3QLF6 [Direct mapping]
Growth factor receptor-bound protein 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 42 aa
4.7 kDa 		No 0
GRB2-210
ENSP00000462785
ENST00000582582
J3KT38 [Direct mapping]
Growth factor receptor-bound protein 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
Show all
 110 aa
12.7 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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