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AGTR2
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  • AGTR2
PROTEIN STRUCTURE
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

AGTR2
Synonyms AT2, MRX88
Gene descriptioni

Full gene name according to HGNC.

Angiotensin II receptor type 2
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
G-protein coupled receptors
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome X
Cytoband q23
Chromosome location (bp) 116170744 - 116174974
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

2
Ensembl ENSG00000180772 (version 103.38)
Entrez gene 186
HGNC HGNC:338
UniProt P50052 (UniProt - Evidence at protein level)
neXtProt NX_P50052
Antibodypedia AGTR2 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 163

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

Off
On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
AGTR2-201
AGTR2-203


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
AGTR2-201
ENSP00000360973
ENST00000371906
P50052 [Direct mapping]
Type-2 angiotensin II receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0001822 [kidney development]
GO:0001974 [blood vessel remodeling]
GO:0001991 [regulation of systemic arterial blood pressure by circulatory renin-angiotensin]
GO:0002018 [renin-angiotensin regulation of aldosterone production]
GO:0004930 [G protein-coupled receptor activity]
GO:0004945 [angiotensin type II receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007199 [G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007420 [brain development]
GO:0008134 [transcription factor binding]
GO:0008217 [regulation of blood pressure]
GO:0008284 [positive regulation of cell population proliferation]
GO:0010243 [response to organonitrogen compound]
GO:0010459 [negative regulation of heart rate]
GO:0010700 [negative regulation of norepinephrine secretion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0021695 [cerebellar cortex development]
GO:0030308 [negative regulation of cell growth]
GO:0032304 [negative regulation of icosanoid secretion]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0035556 [intracellular signal transduction]
GO:0035815 [positive regulation of renal sodium excretion]
GO:0035932 [aldosterone secretion]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0042306 [regulation of protein import into nucleus]
GO:0042311 [vasodilation]
GO:0042416 [dopamine biosynthetic process]
GO:0042981 [regulation of apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048019 [receptor antagonist activity]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051387 [negative regulation of neurotrophin TRK receptor signaling pathway]
GO:0060993 [kidney morphogenesis]
GO:0061049 [cell growth involved in cardiac muscle cell development]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0097746 [regulation of blood vessel diameter]
GO:0097755 [positive regulation of blood vessel diameter]
GO:2000272 [negative regulation of signaling receptor activity]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
363 aa
41.2 kDa
No 7
AGTR2-203
ENSP00000505750
ENST00000681852
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G protein-coupled receptor activity]
GO:0004945 [angiotensin type II receptor activity]
GO:0006954 [inflammatory response]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0042981 [regulation of apoptotic process]
GO:0097746 [regulation of blood vessel diameter]
Show all
363 aa
41.2 kDa
No 7

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