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ADIPOQ
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  • ADIPOQ
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

ADIPOQ
Synonyms ACDC, ACRP30, adiponectin, apM1, GBP28
Gene descriptioni

Full gene name according to HGNC.

Adiponectin, C1Q and collagen domain containing
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Candidate cardiovascular disease genes
Disease related genes
Human disease related genes
Plasma proteins
Potential drug targets
Transporters
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 3
Cytoband q27.3
Chromosome location (bp) 186842704 - 186858463
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

2
Ensembl ENSG00000181092 (version 103.38)
Entrez gene 9370
HGNC HGNC:13633
UniProt Q15848 (UniProt - Evidence at protein level)
neXtProt NX_Q15848
Antibodypedia ADIPOQ antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 2      # Population variants: 162

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
ADIPOQ-201
ADIPOQ-202


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
ADIPOQ-201
ENSP00000320709
ENST00000320741
Q15848 [Direct mapping]
Adiponectin
A8K660 [Target identity:100%; Query identity:100%]
Adiponectin; Adiponectin, C1Q and collagen domain containing; cDNA FLJ78108, highly similar to Homo sapiens adiponectin, C1Q and collagen domain containing (ADIPOQ), mRNA
Show all
Transporters
   Accessory Factors Involved in Transport
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Human disease related genes
   Congenital disorders of metabolism
   Other congenital disorders of metabolism
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005102 [signaling receptor binding]
GO:0005125 [cytokine activity]
GO:0005179 [hormone activity]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006635 [fatty acid beta-oxidation]
GO:0007165 [signal transduction]
GO:0009749 [response to glucose]
GO:0009967 [positive regulation of signal transduction]
GO:0009986 [cell surface]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0010739 [positive regulation of protein kinase A signaling]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010906 [regulation of glucose metabolic process]
GO:0019395 [fatty acid oxidation]
GO:0030336 [negative regulation of cell migration]
GO:0030853 [negative regulation of granulocyte differentiation]
GO:0031953 [negative regulation of protein autophosphorylation]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032869 [cellular response to insulin stimulus]
GO:0033034 [positive regulation of myeloid cell apoptotic process]
GO:0033691 [sialic acid binding]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0034612 [response to tumor necrosis factor]
GO:0035690 [cellular response to drug]
GO:0042304 [regulation of fatty acid biosynthetic process]
GO:0042593 [glucose homeostasis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045650 [negative regulation of macrophage differentiation]
GO:0045721 [negative regulation of gluconeogenesis]
GO:0045776 [negative regulation of blood pressure]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045923 [positive regulation of fatty acid metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0050728 [negative regulation of inflammatory response]
GO:0050765 [negative regulation of phagocytosis]
GO:0050805 [negative regulation of synaptic transmission]
GO:0050873 [brown fat cell differentiation]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070994 [detection of oxidative stress]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0072659 [protein localization to plasma membrane]
GO:0090317 [negative regulation of intracellular protein transport]
GO:0110113 [positive regulation of lipid transporter activity]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:1900121 [negative regulation of receptor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905598 [negative regulation of low-density lipoprotein receptor activity]
GO:2000279 [negative regulation of DNA biosynthetic process]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]
GO:2000478 [positive regulation of metanephric glomerular visceral epithelial cell development]
GO:2000481 [positive regulation of cAMP-dependent protein kinase activity]
GO:2000534 [positive regulation of renal albumin absorption]
GO:2000584 [negative regulation of platelet-derived growth factor receptor-alpha signaling pathway]
GO:2000590 [negative regulation of metanephric mesenchymal cell migration]
Show all
244 aa
26.4 kDa
Yes 0
ADIPOQ-202
ENSP00000389814
ENST00000444204
Q15848 [Direct mapping]
Adiponectin
A8K660 [Target identity:100%; Query identity:100%]
Adiponectin; Adiponectin, C1Q and collagen domain containing; cDNA FLJ78108, highly similar to Homo sapiens adiponectin, C1Q and collagen domain containing (ADIPOQ), mRNA
Show all
Transporters
   Accessory Factors Involved in Transport
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Human disease related genes
   Congenital disorders of metabolism
   Other congenital disorders of metabolism
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005102 [signaling receptor binding]
GO:0005125 [cytokine activity]
GO:0005179 [hormone activity]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006635 [fatty acid beta-oxidation]
GO:0007165 [signal transduction]
GO:0007584 [response to nutrient]
GO:0007623 [circadian rhythm]
GO:0009617 [response to bacterium]
GO:0009744 [response to sucrose]
GO:0009749 [response to glucose]
GO:0009967 [positive regulation of signal transduction]
GO:0009986 [cell surface]
GO:0010467 [gene expression]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0010739 [positive regulation of protein kinase A signaling]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010906 [regulation of glucose metabolic process]
GO:0014823 [response to activity]
GO:0019395 [fatty acid oxidation]
GO:0030336 [negative regulation of cell migration]
GO:0030853 [negative regulation of granulocyte differentiation]
GO:0031667 [response to nutrient levels]
GO:0031953 [negative regulation of protein autophosphorylation]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032869 [cellular response to insulin stimulus]
GO:0032991 [protein-containing complex]
GO:0033034 [positive regulation of myeloid cell apoptotic process]
GO:0033691 [sialic acid binding]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0034612 [response to tumor necrosis factor]
GO:0035690 [cellular response to drug]
GO:0042304 [regulation of fatty acid biosynthetic process]
GO:0042493 [response to drug]
GO:0042593 [glucose homeostasis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0045471 [response to ethanol]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045650 [negative regulation of macrophage differentiation]
GO:0045721 [negative regulation of gluconeogenesis]
GO:0045776 [negative regulation of blood pressure]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045923 [positive regulation of fatty acid metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0046888 [negative regulation of hormone secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050765 [negative regulation of phagocytosis]
GO:0050805 [negative regulation of synaptic transmission]
GO:0050873 [brown fat cell differentiation]
GO:0051384 [response to glucocorticoid]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070543 [response to linoleic acid]
GO:0070994 [detection of oxidative stress]
GO:0071320 [cellular response to cAMP]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0072659 [protein localization to plasma membrane]
GO:0090317 [negative regulation of intracellular protein transport]
GO:0110113 [positive regulation of lipid transporter activity]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:1900121 [negative regulation of receptor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905598 [negative regulation of low-density lipoprotein receptor activity]
GO:2000279 [negative regulation of DNA biosynthetic process]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]
GO:2000478 [positive regulation of metanephric glomerular visceral epithelial cell development]
GO:2000481 [positive regulation of cAMP-dependent protein kinase activity]
GO:2000534 [positive regulation of renal albumin absorption]
GO:2000584 [negative regulation of platelet-derived growth factor receptor-alpha signaling pathway]
GO:2000590 [negative regulation of metanephric mesenchymal cell migration]
Show all
244 aa
26.4 kDa
Yes 0

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