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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
q24.3
Chromosome location (bp)
144291591 - 144314720
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
HSF1-201
HSF1-204
HSF1-212
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q00613 [Direct mapping] Heat shock factor protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000165 [MAPK cascade] GO:0000775 [chromosome, centromeric region] GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0000785 [chromatin] GO:0000791 [euchromatin] GO:0000792 [heterochromatin] GO:0000922 [spindle pole] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001162 [RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding] GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006281 [DNA repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006397 [mRNA processing] GO:0006952 [defense response] GO:0006974 [cellular response to DNA damage stimulus] GO:0007584 [response to nutrient] GO:0008284 [positive regulation of cell population proliferation] GO:0009299 [mRNA transcription] GO:0009408 [response to heat] GO:0010243 [response to organonitrogen compound] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010667 [negative regulation of cardiac muscle cell apoptotic process] GO:0014070 [response to organic cyclic compound] GO:0014823 [response to activity] GO:0016032 [viral process] GO:0016605 [PML body] GO:0019901 [protein kinase binding] GO:0031072 [heat shock protein binding] GO:0031333 [negative regulation of protein-containing complex assembly] GO:0031490 [chromatin DNA binding] GO:0032355 [response to estradiol] GO:0033574 [response to testosterone] GO:0034605 [cellular response to heat] GO:0034620 [cellular response to unfolded protein] GO:0034622 [cellular protein-containing complex assembly] GO:0035690 [cellular response to drug] GO:0035865 [cellular response to potassium ion] GO:0042025 [host cell nucleus] GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein] GO:0042802 [identical protein binding] GO:0043200 [response to amino acid] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0043621 [protein self-association] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046982 [protein heterodimerization activity] GO:0048471 [perinuclear region of cytoplasm] GO:0051028 [mRNA transport] GO:0051879 [Hsp90 protein binding] GO:0061408 [positive regulation of transcription from RNA polymerase II promoter in response to heat stress] GO:0061770 [translation elongation factor binding] GO:0070301 [cellular response to hydrogen peroxide] GO:0071222 [cellular response to lipopolysaccharide] GO:0071230 [cellular response to amino acid stimulus] GO:0071276 [cellular response to cadmium ion] GO:0071280 [cellular response to copper ion] GO:0071392 [cellular response to estradiol stimulus] GO:0071407 [cellular response to organic cyclic compound] GO:0071478 [cellular response to radiation] GO:0071480 [cellular response to gamma radiation] GO:0072738 [cellular response to diamide] GO:0090084 [negative regulation of inclusion body assembly] GO:0090261 [positive regulation of inclusion body assembly] GO:0097165 [nuclear stress granule] GO:0097431 [mitotic spindle pole] GO:0097677 [STAT family protein binding] GO:0098847 [sequence-specific single stranded DNA binding] GO:0101031 [chaperone complex] GO:0120162 [positive regulation of cold-induced thermogenesis] GO:1900034 [regulation of cellular response to heat] GO:1900365 [positive regulation of mRNA polyadenylation] GO:1901215 [negative regulation of neuron death] GO:1901652 [response to peptide] GO:1902512 [positive regulation of apoptotic DNA fragmentation] GO:1903936 [cellular response to sodium arsenite] GO:1904385 [cellular response to angiotensin] GO:1904528 [positive regulation of microtubule binding] GO:1904843 [cellular response to nitroglycerin] GO:1904845 [cellular response to L-glutamine] GO:1990837 [sequence-specific double-stranded DNA binding] GO:1990841 [promoter-specific chromatin binding] GO:1990904 [ribonucleoprotein complex] GO:1990910 [response to hypobaric hypoxia] GO:1990911 [response to psychosocial stress] GO:2001033 [negative regulation of double-strand break repair via nonhomologous end joining]