O60260 [Direct mapping]
E3 ubiquitin-protein ligase parkin

GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000266 [mitochondrial fission]
GO:0000422 [autophagy of mitochondrion]
GO:0000423 [mitophagy]
GO:0001664 [G protein-coupled receptor binding]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0003714 [transcription corepressor activity]
GO:0003779 [actin binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006914 [autophagy]
GO:0006979 [response to oxidative stress]
GO:0007005 [mitochondrion organization]
GO:0007417 [central nervous system development]
GO:0008013 [beta-catenin binding]
GO:0008270 [zinc ion binding]
GO:0008344 [adult locomotory behavior]
GO:0010498 [proteasomal protein catabolic process]
GO:0010506 [regulation of autophagy]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010636 [positive regulation of mitochondrial fusion]
GO:0010637 [negative regulation of mitochondrial fusion]
GO:0010821 [regulation of mitochondrion organization]
GO:0010906 [regulation of glucose metabolic process]
GO:0010994 [free ubiquitin chain polymerization]
GO:0014059 [regulation of dopamine secretion]
GO:0015631 [tubulin binding]
GO:0016235 [aggresome]
GO:0016236 [macroautophagy]
GO:0016567 [protein ubiquitination]
GO:0016579 [protein deubiquitination]
GO:0016607 [nuclear speck]
GO:0016740 [transferase activity]
GO:0017124 [SH3 domain binding]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0030165 [PDZ domain binding]
GO:0030544 [Hsp70 protein binding]
GO:0031072 [heat shock protein binding]
GO:0031396 [regulation of protein ubiquitination]
GO:0031624 [ubiquitin conjugating enzyme binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031647 [regulation of protein stability]
GO:0031648 [protein destabilization]
GO:0032092 [positive regulation of protein binding]
GO:0032232 [negative regulation of actin filament bundle assembly]
GO:0032368 [regulation of lipid transport]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0033132 [negative regulation of glucokinase activity]
GO:0034620 [cellular response to unfolded protein]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035519 [protein K29-linked ubiquitination]
GO:0036503 [ERAD pathway]
GO:0042053 [regulation of dopamine metabolic process]
GO:0042417 [dopamine metabolic process]
GO:0042802 [identical protein binding]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0043005 [neuron projection]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043274 [phospholipase binding]
GO:0043388 [positive regulation of DNA binding]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044257 [cellular protein catabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0044314 [protein K27-linked ubiquitination]
GO:0044828 [negative regulation by host of viral genome replication]
GO:0044877 [protein-containing complex binding]
GO:0045202 [synapse]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046329 [negative regulation of JNK cascade]
GO:0046676 [negative regulation of insulin secretion]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050821 [protein stabilization]
GO:0051087 [chaperone binding]
GO:0051582 [positive regulation of neurotransmitter uptake]
GO:0051865 [protein autoubiquitination]
GO:0055069 [zinc ion homeostasis]
GO:0060548 [negative regulation of cell death]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061734 [parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization]
GO:0070050 [neuron cellular homeostasis]
GO:0070534 [protein K63-linked ubiquitination]
GO:0070842 [aggresome assembly]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071287 [cellular response to manganese ion]
GO:0085020 [protein K6-linked ubiquitination]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097237 [cellular response to toxic substance]
GO:0097413 [Lewy body]
GO:0097602 [cullin family protein binding]
GO:0098779 [positive regulation of mitophagy in response to mitochondrial depolarization]
GO:0098793 [presynapse]
GO:0099073 [mitochondrion-derived vesicle]
GO:0099074 [mitochondrion to lysosome transport]
GO:1900407 [regulation of cellular response to oxidative stress]
GO:1901215 [negative regulation of neuron death]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1902254 [negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
GO:1902283 [negative regulation of primary amine oxidase activity]
GO:1902530 [positive regulation of protein linear polyubiquitination]
GO:1902803 [regulation of synaptic vesicle transport]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1903214 [regulation of protein targeting to mitochondrion]
GO:1903265 [positive regulation of tumor necrosis factor-mediated signaling pathway]
GO:1903351 [cellular response to dopamine]
GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
GO:1903542 [negative regulation of exosomal secretion]
GO:1903599 [positive regulation of autophagy of mitochondrion]
GO:1904049 [negative regulation of spontaneous neurotransmitter secretion]
GO:1905281 [positive regulation of retrograde transport, endosome to Golgi]
GO:1905366 [negative regulation of intralumenal vesicle formation]
GO:1905477 [positive regulation of protein localization to membrane]
GO:1990381 [ubiquitin-specific protease binding]
GO:1990444 [F-box domain binding]
GO:1990452 [Parkin-FBXW7-Cul1 ubiquitin ligase complex]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]

O60260 [Direct mapping]
E3 ubiquitin-protein ligase parkin
X5DR79 [Target identity:100%; Query identity:100%]
RBR-type E3 ubiquitin transferase

GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000266 [mitochondrial fission]
GO:0000422 [autophagy of mitochondrion]
GO:0000423 [mitophagy]
GO:0001664 [G protein-coupled receptor binding]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0001964 [startle response]
GO:0003714 [transcription corepressor activity]
GO:0003779 [actin binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006914 [autophagy]
GO:0006979 [response to oxidative stress]
GO:0007005 [mitochondrion organization]
GO:0007417 [central nervous system development]
GO:0007612 [learning]
GO:0007626 [locomotory behavior]
GO:0008013 [beta-catenin binding]
GO:0008270 [zinc ion binding]
GO:0008344 [adult locomotory behavior]
GO:0010498 [proteasomal protein catabolic process]
GO:0010506 [regulation of autophagy]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010636 [positive regulation of mitochondrial fusion]
GO:0010637 [negative regulation of mitochondrial fusion]
GO:0010821 [regulation of mitochondrion organization]
GO:0010906 [regulation of glucose metabolic process]
GO:0010994 [free ubiquitin chain polymerization]
GO:0014059 [regulation of dopamine secretion]
GO:0015631 [tubulin binding]
GO:0016235 [aggresome]
GO:0016236 [macroautophagy]
GO:0016567 [protein ubiquitination]
GO:0016579 [protein deubiquitination]
GO:0016607 [nuclear speck]
GO:0016740 [transferase activity]
GO:0017124 [SH3 domain binding]
GO:0019538 [protein metabolic process]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0030165 [PDZ domain binding]
GO:0030544 [Hsp70 protein binding]
GO:0031072 [heat shock protein binding]
GO:0031396 [regulation of protein ubiquitination]
GO:0031624 [ubiquitin conjugating enzyme binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031647 [regulation of protein stability]
GO:0031648 [protein destabilization]
GO:0032092 [positive regulation of protein binding]
GO:0032232 [negative regulation of actin filament bundle assembly]
GO:0032368 [regulation of lipid transport]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032991 [protein-containing complex]
GO:0033132 [negative regulation of glucokinase activity]
GO:0034620 [cellular response to unfolded protein]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0035519 [protein K29-linked ubiquitination]
GO:0036503 [ERAD pathway]
GO:0042053 [regulation of dopamine metabolic process]
GO:0042415 [norepinephrine metabolic process]
GO:0042417 [dopamine metabolic process]
GO:0042802 [identical protein binding]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0043005 [neuron projection]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043274 [phospholipase binding]
GO:0043388 [positive regulation of DNA binding]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044257 [cellular protein catabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0044314 [protein K27-linked ubiquitination]
GO:0044828 [negative regulation by host of viral genome replication]
GO:0044877 [protein-containing complex binding]
GO:0045202 [synapse]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046329 [negative regulation of JNK cascade]
GO:0046676 [negative regulation of insulin secretion]
GO:0046872 [metal ion binding]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050804 [modulation of chemical synaptic transmission]
GO:0050821 [protein stabilization]
GO:0051087 [chaperone binding]
GO:0051582 [positive regulation of neurotransmitter uptake]
GO:0051583 [dopamine uptake involved in synaptic transmission]
GO:0051865 [protein autoubiquitination]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0055069 [zinc ion homeostasis]
GO:0060548 [negative regulation of cell death]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061734 [parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization]
GO:0070050 [neuron cellular homeostasis]
GO:0070534 [protein K63-linked ubiquitination]
GO:0070585 [protein localization to mitochondrion]
GO:0070842 [aggresome assembly]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071287 [cellular response to manganese ion]
GO:0085020 [protein K6-linked ubiquitination]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097237 [cellular response to toxic substance]
GO:0097413 [Lewy body]
GO:0097602 [cullin family protein binding]
GO:0098779 [positive regulation of mitophagy in response to mitochondrial depolarization]
GO:0098793 [presynapse]
GO:0099073 [mitochondrion-derived vesicle]
GO:0099074 [mitochondrion to lysosome transport]
GO:1900407 [regulation of cellular response to oxidative stress]
GO:1901215 [negative regulation of neuron death]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1902254 [negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
GO:1902283 [negative regulation of primary amine oxidase activity]
GO:1902530 [positive regulation of protein linear polyubiquitination]
GO:1902803 [regulation of synaptic vesicle transport]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1903214 [regulation of protein targeting to mitochondrion]
GO:1903265 [positive regulation of tumor necrosis factor-mediated signaling pathway]
GO:1903351 [cellular response to dopamine]
GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
GO:1903382 [negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway]
GO:1903542 [negative regulation of exosomal secretion]
GO:1903599 [positive regulation of autophagy of mitochondrion]
GO:1903861 [positive regulation of dendrite extension]
GO:1904049 [negative regulation of spontaneous neurotransmitter secretion]
GO:1905281 [positive regulation of retrograde transport, endosome to Golgi]
GO:1905366 [negative regulation of intralumenal vesicle formation]
GO:1905477 [positive regulation of protein localization to membrane]
GO:1990381 [ubiquitin-specific protease binding]
GO:1990444 [F-box domain binding]
GO:1990452 [Parkin-FBXW7-Cul1 ubiquitin ligase complex]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]

A0A087WX46 [Direct mapping]
E3 ubiquitin-protein ligase parkin

GO:0004842 [ubiquitin-protein transferase activity]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0016567 [protein ubiquitination]
GO:0016607 [nuclear speck]
GO:0016740 [transferase activity]
GO:0046872 [metal ion binding]

A0A087X1E2 [Direct mapping]
E3 ubiquitin-protein ligase parkin

A0A6I8PRS9 [Direct mapping]
E3 ubiquitin-protein ligase parkin