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MUC1
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  • MUC1
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

MUC1
Synonyms ADMCKD, ADMCKD1, CD227, MCD, MCKD, MCKD1, PEM, PUM
Gene descriptioni

Full gene name according to HGNC.

Mucin 1, cell surface associated
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
CD markers
Disease related genes
Human disease related genes
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular,Membrane,Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 1
Cytoband q22
Chromosome location (bp) 155185824 - 155192916
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

23
Ensembl ENSG00000185499 (version 103.38)
Entrez gene 4582
HGNC HGNC:7508
UniProt P15941 (UniProt - Evidence at protein level)
neXtProt NX_P15941
Antibodypedia MUC1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 0

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

Off
On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
«
MUC1-201
MUC1-202
MUC1-203
MUC1-204
MUC1-205
MUC1-206
MUC1-207
MUC1-208
MUC1-209
MUC1-210
MUC1-211
MUC1-212
MUC1-213
MUC1-214
MUC1-218
MUC1-219
MUC1-221
MUC1-223
MUC1-224
MUC1-225
MUC1-226
MUC1-227
MUC1-228
»


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
MUC1-201
ENSP00000338983
ENST00000337604
P15941 [Direct mapping]
Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0002039 [p53 binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003712 [transcription coregulator activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0016324 [apical plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031982 [vesicle]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0070062 [extracellular exosome]
GO:0090240 [positive regulation of histone H4 acetylation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
273 aa
29.6 kDa
Yes 1
MUC1-202
ENSP00000343482
ENST00000338684
A0A0A0MRB3 [Direct mapping]
MUC1-CT
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
Show all
241 aa
25.7 kDa
Yes 1
MUC1-203
ENSP00000342814
ENST00000342482
P15941 [Direct mapping]
Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0002039 [p53 binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003712 [transcription coregulator activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0016324 [apical plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031982 [vesicle]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0070062 [extracellular exosome]
GO:0090240 [positive regulation of histone H4 acetylation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
166 aa
17.3 kDa
Yes 1
MUC1-204
ENSP00000339690
ENST00000343256
P15941 [Direct mapping]
Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0002039 [p53 binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003712 [transcription coregulator activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0016324 [apical plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031982 [vesicle]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0070062 [extracellular exosome]
GO:0090240 [positive regulation of histone H4 acetylation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
203 aa
21.6 kDa
Yes 1
MUC1-205
ENSP00000357374
ENST00000368389
P15941 [Direct mapping]
Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta
Show all
CD markers
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0002039 [p53 binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003712 [transcription coregulator activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0016324 [apical plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031982 [vesicle]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0070062 [extracellular exosome]
GO:0090240 [positive regulation of histone H4 acetylation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
168 aa
18.3 kDa
Yes 0
MUC1-206
ENSP00000357375
ENST00000368390
P15941 [Direct mapping]
Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0002039 [p53 binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003712 [transcription coregulator activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0016324 [apical plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031982 [vesicle]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0070062 [extracellular exosome]
GO:0090240 [positive regulation of histone H4 acetylation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
255 aa
27.6 kDa
Yes 1
MUC1-207
ENSP00000357377
ENST00000368392
P15941 [Direct mapping]
Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0002039 [p53 binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003712 [transcription coregulator activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0016324 [apical plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031982 [vesicle]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0070062 [extracellular exosome]
GO:0090240 [positive regulation of histone H4 acetylation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
264 aa
28.4 kDa
Yes 1
MUC1-208
ENSP00000357378
ENST00000368393
P15941 [Direct mapping]
Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta
Show all
CD markers
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0002039 [p53 binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003712 [transcription coregulator activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0016324 [apical plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031982 [vesicle]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0070062 [extracellular exosome]
GO:0090240 [positive regulation of histone H4 acetylation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
198 aa
21.7 kDa
Yes 0
MUC1-209
ENSP00000357381
ENST00000368396
P15941 [Direct mapping]
Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta
A0A384NPK6 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein
Show all
CD markers
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0002039 [p53 binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003712 [transcription coregulator activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0016324 [apical plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031982 [vesicle]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0070062 [extracellular exosome]
GO:0090240 [positive regulation of histone H4 acetylation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
159 aa
17.1 kDa
Yes 0
MUC1-210
ENSP00000357383
ENST00000368398
P15941 [Direct mapping]
Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0002039 [p53 binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003712 [transcription coregulator activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0016324 [apical plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031982 [vesicle]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0070062 [extracellular exosome]
GO:0090240 [positive regulation of histone H4 acetylation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
Show all
230 aa
24.6 kDa
Yes 1
MUC1-211
ENSP00000389098
ENST00000438413
B1AVQ7 [Direct mapping]
MUC1-CT
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
Show all
229 aa
24.4 kDa
Yes 1
MUC1-212
ENSP00000388172
ENST00000457295
A0A0A0MSH4 [Direct mapping]
MUC1-CT
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
Show all
268 aa
29.6 kDa
Yes 1
MUC1-213
ENSP00000480335
ENST00000462215
A0A087WWM2 [Direct mapping]
Mucin-1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
135 aa
14.2 kDa
Yes 0
MUC1-214
ENSP00000479471
ENST00000462317
A0A087WVJ0 [Direct mapping]
MUC1-CT
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
Show all
228 aa
25.6 kDa
No 1
MUC1-218
ENSP00000484730
ENST00000471283
Q7Z536 [Direct mapping]
Mucin short variant SV10; Mucin-1
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
149 aa
16.3 kDa
Yes 0
MUC1-219
ENSP00000478068
ENST00000485118
A0A087WTR1 [Direct mapping]
Mucin-1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
85 aa
8.9 kDa
No 0
MUC1-221
ENSP00000483482
ENST00000610359
A0A087X0L2 [Direct mapping]
Mucin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
239 aa
25.4 kDa
Yes 1
MUC1-223
ENSP00000480333
ENST00000611571
A0A087WWM1 [Direct mapping]
MUC1-CT
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
Show all
1262 aa
123 kDa
Yes 1
MUC1-224
ENSP00000483581
ENST00000611577
A6ZIE3 [Direct mapping]
MUC1 isoform M9; Mucin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
213 aa
21.9 kDa
Yes 1
MUC1-225
ENSP00000484824
ENST00000612778
A0A087X2A4 [Direct mapping]
MUC1-CT
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
Show all
484 aa
50.1 kDa
Yes 1
MUC1-226
ENSP00000482988
ENST00000614519
A0A087WZZ6 [Direct mapping]
MUC1-CT
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
Show all
123 aa
13.3 kDa
Yes 0
MUC1-227
ENSP00000483473
ENST00000615517
A6ZIE4 [Direct mapping]
MUC1 isoform M10; Mucin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
189 aa
20 kDa
Yes 1
MUC1-228
ENSP00000481231
ENST00000620103
A0A0C4DGW3 [Direct mapping]
MUC1-CT
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Congenital malformations
   Congenital malformations of the urinary system
   Urinary system diseases
   Kidney diseases
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
Show all
475 aa
49.2 kDa
Yes 1

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