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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
FDA approved drug targets Metabolic proteins Nuclear receptors Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q13.31
Chromosome location (bp)
46150521 - 46243756
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
PPARA-201
PPARA-202
PPARA-203
PPARA-204
PPARA-205
PPARA-206
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q07869 [Direct mapping] Peroxisome proliferator-activated receptor alpha F1D8S4 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 1 group C member 1
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Metabolic proteins Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006631 [fatty acid metabolic process] GO:0008134 [transcription factor binding] GO:0008144 [drug binding] GO:0008270 [zinc ion binding] GO:0008289 [lipid binding] GO:0009267 [cellular response to starvation] GO:0009755 [hormone-mediated signaling pathway] GO:0010565 [regulation of cellular ketone metabolic process] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010887 [negative regulation of cholesterol storage] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0019216 [regulation of lipid metabolic process] GO:0019217 [regulation of fatty acid metabolic process] GO:0030154 [cell differentiation] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0031624 [ubiquitin conjugating enzyme binding] GO:0032000 [positive regulation of fatty acid beta-oxidation] GO:0032099 [negative regulation of appetite] GO:0032922 [circadian regulation of gene expression] GO:0033993 [response to lipid] GO:0042752 [regulation of circadian rhythm] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045070 [positive regulation of viral genome replication] GO:0045820 [negative regulation of glycolytic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045923 [positive regulation of fatty acid metabolic process] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046321 [positive regulation of fatty acid oxidation] GO:0046872 [metal ion binding] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048511 [rhythmic process] GO:0050728 [negative regulation of inflammatory response] GO:0051898 [negative regulation of protein kinase B signaling] GO:1900016 [negative regulation of cytokine production involved in inflammatory response] GO:1902894 [negative regulation of pri-miRNA transcription by RNA polymerase II] GO:1903038 [negative regulation of leukocyte cell-cell adhesion] GO:1903427 [negative regulation of reactive oxygen species biosynthetic process] GO:1903944 [negative regulation of hepatocyte apoptotic process] GO:2000191 [regulation of fatty acid transport] GO:2000272 [negative regulation of signaling receptor activity] GO:2001171 [positive regulation of ATP biosynthetic process]
Q07869 [Direct mapping] Peroxisome proliferator-activated receptor alpha F1D8S4 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 1 group C member 1
Show all
Metabolic proteins Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006631 [fatty acid metabolic process] GO:0008134 [transcription factor binding] GO:0008144 [drug binding] GO:0008270 [zinc ion binding] GO:0008289 [lipid binding] GO:0009267 [cellular response to starvation] GO:0009755 [hormone-mediated signaling pathway] GO:0010565 [regulation of cellular ketone metabolic process] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010887 [negative regulation of cholesterol storage] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0019216 [regulation of lipid metabolic process] GO:0019217 [regulation of fatty acid metabolic process] GO:0030154 [cell differentiation] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0031624 [ubiquitin conjugating enzyme binding] GO:0032000 [positive regulation of fatty acid beta-oxidation] GO:0032099 [negative regulation of appetite] GO:0032922 [circadian regulation of gene expression] GO:0033993 [response to lipid] GO:0042752 [regulation of circadian rhythm] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045070 [positive regulation of viral genome replication] GO:0045820 [negative regulation of glycolytic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045923 [positive regulation of fatty acid metabolic process] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046321 [positive regulation of fatty acid oxidation] GO:0046872 [metal ion binding] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048511 [rhythmic process] GO:0050728 [negative regulation of inflammatory response] GO:0051898 [negative regulation of protein kinase B signaling] GO:1900016 [negative regulation of cytokine production involved in inflammatory response] GO:1902894 [negative regulation of pri-miRNA transcription by RNA polymerase II] GO:1903038 [negative regulation of leukocyte cell-cell adhesion] GO:1903427 [negative regulation of reactive oxygen species biosynthetic process] GO:1903944 [negative regulation of hepatocyte apoptotic process] GO:2000191 [regulation of fatty acid transport] GO:2000272 [negative regulation of signaling receptor activity] GO:2001171 [positive regulation of ATP biosynthetic process]
Q07869 [Direct mapping] Peroxisome proliferator-activated receptor alpha F1D8S4 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 1 group C member 1
Show all
Metabolic proteins Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001223 [transcription coactivator binding] GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001666 [response to hypoxia] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006631 [fatty acid metabolic process] GO:0007507 [heart development] GO:0008134 [transcription factor binding] GO:0008144 [drug binding] GO:0008270 [zinc ion binding] GO:0008289 [lipid binding] GO:0008544 [epidermis development] GO:0009267 [cellular response to starvation] GO:0009755 [hormone-mediated signaling pathway] GO:0010468 [regulation of gene expression] GO:0010565 [regulation of cellular ketone metabolic process] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010876 [lipid localization] GO:0010883 [regulation of lipid storage] GO:0010887 [negative regulation of cholesterol storage] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0014070 [response to organic cyclic compound] GO:0019216 [regulation of lipid metabolic process] GO:0019217 [regulation of fatty acid metabolic process] GO:0019902 [phosphatase binding] GO:0019904 [protein domain specific binding] GO:0030154 [cell differentiation] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0031624 [ubiquitin conjugating enzyme binding] GO:0032000 [positive regulation of fatty acid beta-oxidation] GO:0032091 [negative regulation of protein binding] GO:0032099 [negative regulation of appetite] GO:0032868 [response to insulin] GO:0032922 [circadian regulation of gene expression] GO:0033993 [response to lipid] GO:0035095 [behavioral response to nicotine] GO:0038023 [signaling receptor activity] GO:0042060 [wound healing] GO:0042157 [lipoprotein metabolic process] GO:0042752 [regulation of circadian rhythm] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044877 [protein-containing complex binding] GO:0045070 [positive regulation of viral genome replication] GO:0045471 [response to ethanol] GO:0045722 [positive regulation of gluconeogenesis] GO:0045776 [negative regulation of blood pressure] GO:0045820 [negative regulation of glycolytic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045923 [positive regulation of fatty acid metabolic process] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046321 [positive regulation of fatty acid oxidation] GO:0046872 [metal ion binding] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048511 [rhythmic process] GO:0050728 [negative regulation of inflammatory response] GO:0051525 [NFAT protein binding] GO:0051898 [negative regulation of protein kinase B signaling] GO:0061052 [negative regulation of cell growth involved in cardiac muscle cell development] GO:0070166 [enamel mineralization] GO:0097371 [MDM2/MDM4 family protein binding] GO:1900016 [negative regulation of cytokine production involved in inflammatory response] GO:1901215 [negative regulation of neuron death] GO:1902894 [negative regulation of pri-miRNA transcription by RNA polymerase II] GO:1903038 [negative regulation of leukocyte cell-cell adhesion] GO:1903427 [negative regulation of reactive oxygen species biosynthetic process] GO:1903944 [negative regulation of hepatocyte apoptotic process] GO:2000191 [regulation of fatty acid transport] GO:2000272 [negative regulation of signaling receptor activity] GO:2001171 [positive regulation of ATP biosynthetic process]
The Human Protein Atlas project is funded
