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HMGB1
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  • HMGB1
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

HMGB1
Synonyms DKFZp686A04236, HMG1, HMG3, SBP-1
Gene descriptioni

Full gene name according to HGNC.

High mobility group box 1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Plasma proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular,Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 13
Cytoband q12.3
Chromosome location (bp) 30456704 - 30617597
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

6
Ensembl ENSG00000189403 (version 103.38)
Entrez gene 3146
HGNC HGNC:4983
UniProt P09429 (UniProt - Evidence at protein level)
neXtProt NX_P09429
Antibodypedia HMGB1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 27

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
HMGB1-201
HMGB1-202
HMGB1-203
HMGB1-204
HMGB1-205
HMGB1-206


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
HMGB1-201
ENSP00000369904
ENST00000326004
Q5T7C4 [Direct mapping]
High mobility group protein B1
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0045087 [innate immune response]
Show all
158 aa
18.3 kDa
No 0
HMGB1-202
ENSP00000343040
ENST00000339872
P09429 [Direct mapping]
High mobility group protein B1
A0A024RDR0 [Target identity:100%; Query identity:100%]
High-mobility group box 1, isoform CRA_a
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000785 [chromatin]
GO:0000793 [condensed chromosome]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0001786 [phosphatidylserine binding]
GO:0002218 [activation of innate immune response]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0002840 [regulation of T cell mediated immune response to tumor cell]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0005125 [cytokine activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006281 [DNA repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006310 [DNA recombination]
GO:0006342 [chromatin silencing]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006914 [autophagy]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010508 [positive regulation of autophagy]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016829 [lyase activity]
GO:0017053 [transcription repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcription preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032147 [activation of protein kinase activity]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0032640 [tumor necrosis factor production]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032732 [positive regulation of interleukin-1 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0033151 [V(D)J recombination]
GO:0034165 [positive regulation of toll-like receptor 9 signaling pathway]
GO:0034774 [secretory granule lumen]
GO:0035711 [T-helper 1 cell activation]
GO:0035868 [alphav-beta3 integrin-HMGB1 complex]
GO:0042056 [chemoattractant activity]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043277 [apoptotic cell clearance]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043312 [neutrophil degranulation]
GO:0043371 [negative regulation of CD4-positive, alpha-beta T cell differentiation]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045087 [innate immune response]
GO:0045859 [regulation of protein kinase activity]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051106 [positive regulation of DNA ligation]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070491 [repressing transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097100 [supercoiled DNA binding]
GO:0097350 [neutrophil clearance]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2000426 [negative regulation of apoptotic cell clearance]
GO:2001200 [positive regulation of dendritic cell differentiation]
Show all
215 aa
24.9 kDa
No 0
HMGB1-203
ENSP00000345347
ENST00000341423
P09429 [Direct mapping]
High mobility group protein B1
A0A024RDR0 [Target identity:100%; Query identity:100%]
High-mobility group box 1, isoform CRA_a
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000785 [chromatin]
GO:0000793 [condensed chromosome]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001530 [lipopolysaccharide binding]
GO:0001654 [eye development]
GO:0001773 [myeloid dendritic cell activation]
GO:0001786 [phosphatidylserine binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001935 [endothelial cell proliferation]
GO:0002218 [activation of innate immune response]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002270 [plasmacytoid dendritic cell activation]
GO:0002281 [macrophage activation involved in immune response]
GO:0002376 [immune system process]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0002840 [regulation of T cell mediated immune response to tumor cell]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005125 [cytokine activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006310 [DNA recombination]
GO:0006342 [chromatin silencing]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006914 [autophagy]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010508 [positive regulation of autophagy]
GO:0010858 [calcium-dependent protein kinase regulator activity]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016829 [lyase activity]
GO:0017053 [transcription repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcription preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0030295 [protein kinase activator activity]
GO:0030324 [lung development]
GO:0031175 [neuron projection development]
GO:0031497 [chromatin assembly]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032147 [activation of protein kinase activity]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0032640 [tumor necrosis factor production]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032732 [positive regulation of interleukin-1 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033151 [V(D)J recombination]
GO:0034137 [positive regulation of toll-like receptor 2 signaling pathway]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0034165 [positive regulation of toll-like receptor 9 signaling pathway]
GO:0034774 [secretory granule lumen]
GO:0035711 [T-helper 1 cell activation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035868 [alphav-beta3 integrin-HMGB1 complex]
GO:0042056 [chemoattractant activity]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043277 [apoptotic cell clearance]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043312 [neutrophil degranulation]
GO:0043371 [negative regulation of CD4-positive, alpha-beta T cell differentiation]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045087 [innate immune response]
GO:0045089 [positive regulation of innate immune response]
GO:0045639 [positive regulation of myeloid cell differentiation]
GO:0045819 [positive regulation of glycogen catabolic process]
GO:0045859 [regulation of protein kinase activity]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051106 [positive regulation of DNA ligation]
GO:0051384 [response to glucocorticoid]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070491 [repressing transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0090303 [positive regulation of wound healing]
GO:0097100 [supercoiled DNA binding]
GO:0097350 [neutrophil clearance]
GO:0098761 [cellular response to interleukin-7]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2000426 [negative regulation of apoptotic cell clearance]
GO:2000819 [regulation of nucleotide-excision repair]
GO:2001200 [positive regulation of dendritic cell differentiation]
Show all
215 aa
24.9 kDa
No 0
HMGB1-204
ENSP00000382412
ENST00000399489
Q5T7C4 [Direct mapping]
High mobility group protein B1
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0045087 [innate immune response]
Show all
158 aa
18.3 kDa
No 0
HMGB1-205
ENSP00000382417
ENST00000399494
P09429 [Direct mapping]
High mobility group protein B1
A0A024RDR0 [Target identity:100%; Query identity:100%]
High-mobility group box 1, isoform CRA_a
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000785 [chromatin]
GO:0000793 [condensed chromosome]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0001786 [phosphatidylserine binding]
GO:0002218 [activation of innate immune response]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0002840 [regulation of T cell mediated immune response to tumor cell]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0005125 [cytokine activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006281 [DNA repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006310 [DNA recombination]
GO:0006342 [chromatin silencing]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006914 [autophagy]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010508 [positive regulation of autophagy]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016829 [lyase activity]
GO:0017053 [transcription repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcription preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032147 [activation of protein kinase activity]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0032640 [tumor necrosis factor production]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032732 [positive regulation of interleukin-1 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0033151 [V(D)J recombination]
GO:0034165 [positive regulation of toll-like receptor 9 signaling pathway]
GO:0034774 [secretory granule lumen]
GO:0035711 [T-helper 1 cell activation]
GO:0035868 [alphav-beta3 integrin-HMGB1 complex]
GO:0042056 [chemoattractant activity]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043277 [apoptotic cell clearance]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043312 [neutrophil degranulation]
GO:0043371 [negative regulation of CD4-positive, alpha-beta T cell differentiation]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045087 [innate immune response]
GO:0045859 [regulation of protein kinase activity]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051106 [positive regulation of DNA ligation]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070491 [repressing transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097100 [supercoiled DNA binding]
GO:0097350 [neutrophil clearance]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2000426 [negative regulation of apoptotic cell clearance]
GO:2001200 [positive regulation of dendritic cell differentiation]
Show all
215 aa
24.9 kDa
No 0
HMGB1-206
ENSP00000384678
ENST00000405805
P09429 [Direct mapping]
High mobility group protein B1
A0A024RDR0 [Target identity:100%; Query identity:100%]
High-mobility group box 1, isoform CRA_a
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000785 [chromatin]
GO:0000793 [condensed chromosome]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0001786 [phosphatidylserine binding]
GO:0002218 [activation of innate immune response]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0002840 [regulation of T cell mediated immune response to tumor cell]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0005125 [cytokine activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006281 [DNA repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006310 [DNA recombination]
GO:0006342 [chromatin silencing]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006914 [autophagy]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010508 [positive regulation of autophagy]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016829 [lyase activity]
GO:0017053 [transcription repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcription preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032147 [activation of protein kinase activity]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0032640 [tumor necrosis factor production]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032732 [positive regulation of interleukin-1 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0033151 [V(D)J recombination]
GO:0034165 [positive regulation of toll-like receptor 9 signaling pathway]
GO:0034774 [secretory granule lumen]
GO:0035711 [T-helper 1 cell activation]
GO:0035868 [alphav-beta3 integrin-HMGB1 complex]
GO:0042056 [chemoattractant activity]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043277 [apoptotic cell clearance]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043312 [neutrophil degranulation]
GO:0043371 [negative regulation of CD4-positive, alpha-beta T cell differentiation]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045087 [innate immune response]
GO:0045859 [regulation of protein kinase activity]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051106 [positive regulation of DNA ligation]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070491 [repressing transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097100 [supercoiled DNA binding]
GO:0097350 [neutrophil clearance]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2000426 [negative regulation of apoptotic cell clearance]
GO:2001200 [positive regulation of dendritic cell differentiation]
Show all
215 aa
24.9 kDa
No 0

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